<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07200

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTDASLINTIILSGIANIRYKCYVQSYPKTSLVSFLTCESFHGNPSYMDPPESHNALIDAYRHILALNIPATWHILSNQKTDKDTVTLELWIFWFDNKHTQVIETDARLKELHESKSGSFNWNQITSKNGLSPTSSPQLSQSKAESITLVPGIDYKLFIKSIRHLIQHVMIHKRHALALGEFFVFPETYQDDGNVMKDEMANYDPMSVKNTMLACMYNVYFTTSNLVFQPNTRRMRLRPLCTADVYSTHMKVLLCPTGEHARIVSFHSLPTDMQSKVLDQWAEFYDMPVSLLTQKKDLMPLLITLRTASQDTVVYPSALVFVPTDTKQSPAAVAGMNGIMGLNHGLTEDLGAKASRAAYYERLLLNNTQAKDATVDYWSYRNPIIHVGNAVFEALSTVDAKYQQDQLMLHRALIEPIVGSPIMNAKSVVPTNYDSPLLMPGLHRKSTTPPTASFAQQECSMQLAEYATSRFDDTPADDLMLGLLQDTVATSTDSLDIGGGSHLSALLTRALIIDSTDHLSLPASDNTTAQQPSAPLQIQSALPQPQANALPIKDESHVSQPPLEDFDLMYDLGGASLHKADAWDADDGFGDLDLDVTDADFDFFETPAVVAAAAATAPPPPVPASEPNVLHIIPMDIDSPKADLVQAQEQPEPIDQEMVDVQVSELKPTPNNNDSLFTPFVVSHDSTENTSTTAATVDEASYTATPSIMQETSTLQKRFAYQKSTPEPSSFVPRDFLPVPVETSVNDAKYSAGGKFMYDPSKDQAKTDSKGFDLSKKALFYSPDYVPTRPKKKLNKSKQQALKENKDDLSLDTQAKATWSDHDKEESSSGSNSDSSSSGSSGSDSGNSSGSSDSFTTDDSQDSDTESESDIDKMDDSTGHEGLIEKRFRALKRFQKSVVYSQLKATPAPVPTDRLQSLDYDTPFAPILAHGSIKPIKWRHSKAMEESLAYLCEQAVLGGYPLAGGLAEVSENGGEIDGEPAKVLMARRNNLMQMTRGVVTHVPSLQADVFSMTNEFRSILQDTFIETAREEHSDMGTTTPDALEPVSYPNSPLMGKIDIKGPLSIQEYYDLNESHNHGHSKYGKYQIKKRRPDEPNLDVIKRPDIVVSRHEDNLKGSSTMIPFWEKLGLDPYSAKKQIKYLVVYPNNSDIEASVRHFFKGLGNVYEACHLGRHEPGYAGPFTNGLVPVSVADLDNNDSSVRQRLKSYEETCETVGRHLAMDEEQQKQQHFAQSCYTVVYIVNPGPHMSSYLDMCRCFHKLKEAYARIAHKNFIDQQPRIALQLMPIDHLLRPSAFGGYTMLGMKDIAFSVYSKCFARVTRKITRPNQASWADIYAPAFVLTRPLQRTIKFKLNDIRPFPTIMEQNAVLHMAYCFSYDRAWMSVVWVDDRGELLEYDLFSRKTAFKEAWQRTLEIAKRTAFPWTIVITKLGLMFNDELLYWLRYVSAAIEHHVTIVAMDVESGLNLHFNACYPNRDRAVLQQQHDAHQPSFLDAHGKTVAGGMHYAREQQQQQQSKRHRSNSTASTAVSEAQILLLNHRVSYSQKRERAYKGILRPEAITEKENWMIPLATGYLIHHSLPNKNVNPCMEQFNNEAFVAEIHLLYNQTDVSAYSTLQDIIKRLYALSFINPIPSSHTCMPYHVVVAERLSRVLLVIDDSIK
Length1660
PositionKinase
OrganismMucor circinelloides f. lusitanicus CBS 277.49
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.08
Grand average of hydropathy-0.403
Instability index50.23
Isoelectric point5.73
Molecular weight185810.68
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07200
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.27|      15|     824|      49|      63|       2
---------------------------------------------------------------------------
   49-   63 (28.83/18.51)	MDPPESHNALIDA.YR
  875-  890 (23.44/13.57)	MDDSTGHEGLIEKrFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.99|      13|      15|     493|     505|       4
---------------------------------------------------------------------------
  493-  505 (23.53/14.71)	TDSLDIGGGSHLS
  509-  521 (22.46/13.68)	TRALIIDSTDHLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.49|      16|      18|     829|     846|       5
---------------------------------------------------------------------------
  829-  846 (20.17/16.82)	SSGSnSDSSSSGSSgSDS
  849-  864 (30.32/15.06)	SSGS.SDSFTTDDS.QDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.22|      28|      30|     383|     412|       6
---------------------------------------------------------------------------
  383-  412 (46.21/38.03)	NPIihVGNAVFEALSTVDAKYQQDQLM..LHR
  416-  445 (48.01/32.09)	EPI..VGSPIMNAKSVVPTNYDSPLLMpgLHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.31|      33|     824|     694|     744|       7
---------------------------------------------------------------------------
  607-  657 (45.62/24.39)	TPAVVAAAAATAPPP..................PVPASepnvlhiipmdidspkadLVQAQEQPEPIDQ
  694-  744 (46.69/56.24)	TAATVDEASYTATPSimqetstlqkrfayqkstPEPSS..................FVPRDFLPVPVET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.53|      16|     234|    1220|    1236|      15
---------------------------------------------------------------------------
 1220- 1236 (28.14/22.50)	AMDEEQQKQQHFaQSCY
 1457- 1472 (31.38/20.17)	AMDVESGLNLHF.NACY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.66|      15|      20|     347|     361|      16
---------------------------------------------------------------------------
  347-  361 (24.32/13.13)	LTEDLGAKASRAAYY
  365-  379 (26.34/14.78)	LLNNTQAKDATVDYW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07200 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SLPASDNTTAQQPSAPLQIQSALPQPQANALPIKDESHV
2) SPKADLVQAQEQPEPIDQEMVDVQVSELKPTP
3) YVPTRPKKKLNKSKQQALKENKDDLSLDTQAKATWSDHDKEESSSGSNSDSSSSGSSGSDSGNSSGSSDSFTTDDSQDSDTESESDIDKMDDSTGHEG
521
640
786
559
671
883










Molecular Recognition Features






MoRF SequenceStartStop




1) LSKKALFYSPDY
2) RPKKKLNK
775
790
786
797