<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07195

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMNENNKKMQLELLMEKLRHKTSHLNLTDSAKTFRMTILEKRYNNDTVEKLQYQKCLDLLQTNMKVTSLQSMLERLESISRQAGLKFTADGSGRAFFISSDMFYLEVIVEQGGSVCEIHIQHEGKSEPQTCNEIAVCLNSGNFSKFTNHLQGLCAIYQVSADKKLKAKAFAALSALELDLGSMSKLQVYRQDIAMLVHKSPLGIVMPRVGGLPLTLTYFLSPYDLVNVQSPTLTMTLEKILEKNAGLSCTIGIDSANNFQLPISPLFSVTRNSEGESVPAFSPLNAVNSASLPATFVLRMRDPLVLCFSFAQQIKSITGMEVGNWDQPEHLFRSLIKTISKGLIECSGIEDGISRALHVTLPDQQHSYFITESEDAALKCCSVSSIPFSHPSHVPQILAILRRQGLLNALLSSCIRPKSQSDSDAALTFEINSIALDHMSVTFEHPLLEQMCSVEIDLGMDPTCIRCSLFGAEDERTSSDEYATRVLQRCLSIPVTMRAILRQMQSPSSRWSNGPGDPQGSFERRFQTHTNGDSDSHTGPNGQYGNPSFTGGGGGGGFDSGHSPRTHNIGNNDVMMHQSMSNPHASTPKETENESFNGEMEQPGEVVSLAEDGTSANRSKAQFLPASESRTSTSTLGNADLTKYSVNSHSSDSILGITLNNSSTQFNPVRRLNNDVSLKSEPVDMEVSVLEPTTENNQIITEDADSLSSNDAVASLLNVSKSRESPSPKSKSAYPSVSITPVNSLHTSSHTAAYPNINLERRPGIEIIPFSKDSSSSSIPSSLTITPVGGKPPKEKSKYKDFRLKESLALDSETKERDRDKERERKERKRRREGEKSPSSGSGGKPTKMMSLSATLMGPPGALLKLDSSPKLSHKNNSSGSNSGSTPPANTNQSPLTSPSKSSSKSSTPSSSPKHPSSGGKPSMSALSMSALKCSTSPSSKSKKSKDRDRERSDKDRDRDKDRERDRDKDRERDRERDKDRSRDREKKSRTPTPTSNHHSRGPPLLKTKSLDFALAVEDKSEETKEDNSFDSILALATANSEMLPSQLDLQSSIHAVTQELLSFSPPTLSDSENGKVSGSTGGLPGDGSMSCPSSGNPNKSPLRSRKSSLSAVIDKLRLQHNPESDVFQNSGPKYGADPASRMEQSEGRSSFMDELMEGSDSSASPKTNDVEDNMHFNRIHSGSNSPNDPFSQEDSGINETTDAHEGECNGDSLPDKEFVKPFPPPSARGTYGIRPHGYLSNSEADLNPNSPSVSVHIVNVPSPLALQQTRSPLANQLALVTATSGPSPASSTPQSSPCIIDDDLMDEALVGLGK
Length1314
PositionMiddle
OrganismDaphnia magna
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.04
Grand average of hydropathy-0.642
Instability index59.15
Isoelectric point6.12
Molecular weight142802.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07195
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     157.18|      21|      73|     825|     845|       1
---------------------------------------------------------------------------
  519-  546 (22.41/ 6.63)	G..SFERRfqTHTNG.DSDS.....H...............TGpngqyGNP
  825-  845 (34.62/15.08)	K..ERKRR..REGEK.SPSS.....G...............SG.....GKP
  866-  886 (29.54/11.56)	D..SSPKL..SHKNN.SSGS.....N...............SG.....STP
  896-  921 (23.71/ 7.53)	T..SPSKS..SSKSS.TPSSspkhpS...............SG.....GKP
  968- 1003 (23.55/ 7.41)	K..DRERD..RERDK.DRSR.....DrekksrtptptsnhhSR.....GPP
 1166- 1189 (23.35/ 7.28)	KtnDVEDN..MHFNRiHSGS.....N...............SP.....NDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.24|      43|      54|    1050|    1095|       2
---------------------------------------------------------------------------
 1050- 1095 (67.37/38.02)	QSSIHAVTQEL.LSFSPPTlsDSENGKVSGSTGGLPGDGSMScPSSG
 1106- 1147 (67.20/29.51)	KSSLSAVIDKLrLQHNP....ESDVFQNSGPKYGADPASRME.QSEG
 1222- 1243 (29.68/ 9.18)	..............FPPPS........ARG.TYGIRPHGYLS.NSE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.30|      33|     139|     792|     824|       3
---------------------------------------------------------------------------
  727-  766 (42.90/24.15)	PKSKSAYPSVSITpvNSLHTSSHTAAYpninlERRPGIEI
  792-  824 (57.08/34.86)	PKEKSKYKDFRLK..ESLALDSETKER.....DRDKERER
  937-  964 (48.32/28.24)	PSSKSKKSKDRDR..ER....SD.KDR.....DRDKDRER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.47|      30|      66|     565|     594|       4
---------------------------------------------------------------------------
  565-  594 (54.59/31.75)	THNIGNNDVMMHQSMSNPHASTPKETENES
  632-  661 (46.61/25.95)	TSTLGNADLTKYSVNSHSSDSILGITLNNS
  668-  685 (23.28/ 8.99)	VRRL.NNDVSLK........SEPVDME...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.78|      43|     868|     375|     420|       6
---------------------------------------------------------------------------
  375-  420 (71.64/52.88)	AALKCCSVS.SIpfsHPSHVPQILAILR.RQGLLN..ALLSSCIRPKSQS
 1244- 1290 (62.14/37.21)	ADLNPNSPSvSV...HIVNVPSPLALQQtRSPLANqlALVTATSGPSPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.83|      17|      19|    1006|    1022|      10
---------------------------------------------------------------------------
 1006- 1022 (26.17/19.26)	KTKSLDFALAVEDKSEE
 1025- 1041 (26.66/19.77)	EDNSFDSILALATANSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.12|      21|      65|     704|     725|      11
---------------------------------------------------------------------------
  611-  631 (36.29/16.31)	DGTSANRSKAQFLPASESRTS
  704-  724 (33.83/19.73)	DSLSSNDAVASLLNVSKSRES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07195 with Med1 domain of Kingdom Metazoa
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