<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07194

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTAGAIEAVLRYAYVHGYSCEQWAEPTRQCFQRVDHKLDKELCDVLLNQIFCLIRVADPLLESYLTFATTGHKDLTSPLLPGASLLDPIFISPKVLLQSLAQYVDSTAGRNPRQWAYLLRLVSVLLAPLDAEKIVNSVHQQKIVDSDQPSQDDWFDVLATVFVMLSRLVAVGLEHESRDREPKPGPRLVRSAISFQRGNTQPGDISTIWPSSSNYLSSQTSAYDPEATIDEDSFGHEALEEEKEQDIKSSAKRRRTGAGDGIGAGARNGSGNEEDEDEEDEEEKIERSNAIMASQIMIDLIEKKSAKRMFEVRQNQKRQHGHESTSEEPWATCQEILTGPSLHSSSKKSGVGSLRQNPHVQKLLILIGRLTDRNLERMMAVHMKYHELEDEGTARAMPSAGLMGLLYHVVQIRPTLDDETIVDHLIKLQTIKGSFDESFYLELWFTALTGLREASFGTSCQTQSFESKLEKNTVDRKEKSCNNAIATNRLLWRSLVLVKLPHLIKMMQKKSEAKASRRPWKEHKGGFKDDVVEKELNPLESSLLELKAFTGLLNACSPPACCSDFYAPSSQSSDLVDKLGRGSTEDEDDALMTLINTISDDFNTPTVTKAIRSISTESIFLNMVHVCESYGFIRPHVVRILSCSSSAAGGSGSATVSSSVNKTECDTTTDLMDTDILDMDSPLGNNNSNSKTHRNLMEDPEDCSMDSIEIIRQNIEARMESILIECSMTAVRELLEISIVSLVHLRRIIDFLIDLLQQKASLGDIETIAQICSAMNAYPCIVDLIIQLYSPLAFMGPFEELCNGWSPSDSGMFIDEEEEVKSAKSLYNEFGTIWIFVSFVVDRFNLIRDLDRVFRVREGFCYQFFSQGPVVYGIDASVPDMEVWVSKWQNALFENDVTGELLREMTPQRLLAIGPTIIKRVMMSFEEDEMGVSLLPSVLDYLQEPYLHFTLGPILMLLCDELMSTQYRTALMCLDRLIIEGNLPELLVRQCGGVILGSLESIAGENQTYNNGENDAEENERKRARMNRIKTRVESIMEIEDSDARFPPTETVTTRVTRHSLFSKTQEMFRAIVKGGRSMFMRDMDADTHALWDQSKGTTQMVAHYLDMVLFQTALEMGGPRWFISMIVQEVLEAGKSGGAVRAAELGSCLIAIPLSFSSHGHNGCVYLLQCLLQDILPSSLRQSAANNGSFFQGQTLGVFTSDCLVLMHGRPLDDKLDDTDDRMVRALGRIFLNSLGMEGHETSQPSEADVMECGQFAEWTGDITKSAVWRGFIKGLMSNPSINDAWPDAFIY
Length1293
PositionTail
OrganismPhycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Phycomycetaceae> Phycomyces.
Aromaticity0.07
Grand average of hydropathy-0.239
Instability index46.97
Isoelectric point4.93
Molecular weight144685.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364142

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07194
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.66|      37|     285|     118|     158|       1
---------------------------------------------------------------------------
  118-  158 (53.06/47.11)	LLRLVsVLLAP.LDAEKIVNsvHQQKIvDSDQPSQDD......WFDVL
  405-  448 (55.60/34.38)	LLYHV.VQIRPtLDDETIVD..HLIKL.QTIKGSFDEsfylelWFTAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.18|      41|     231|     329|     372|       2
---------------------------------------------------------------------------
  329-  372 (64.79/53.69)	PWATCQEiLTGPSLHSSS..KKSGVGSLRQNPhvQKLLILIGRLTD
  558-  600 (70.38/46.54)	PPACCSD.FYAPSSQSSDlvDKLGRGSTEDED..DALMTLINTISD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.43|      78|     231|     909|    1018|       3
---------------------------------------------------------------------------
  934- 1018 (115.59/133.40)	LLPSVLDYLQEPYLHFTLGPILMLLCDELMSTQYRTALmcLDRLiieGNLPELLVRQCGGVILGSLeSIAGeNQTYNNGENDAEE
 1176- 1253 (134.83/80.08)	ILPSSLRQSAANNGSFFQGQTLGVFTSDCLVLMHGRPL..DDKL...DDTDDRMVRALGRIFLNSL.GMEG.HETSQPSEADVME
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07194 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KRMFEVRQNQKRQHGHESTSEEPWATCQEILTG
2) QTSAYDPEATIDEDSFGHEALEEEKEQDIKSSAKRRRTGAGDGIGAGARNGSGNEEDEDEEDEEEKIERSNAI
307
219
339
291










Molecular Recognition Features






MoRF SequenceStartStop




NANANA