<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07179

Description RNA polymerase II mediator complex component Srb8
SequenceMAIDSSAEEPLLAANAQDQQPDDDDARSSKSKINTKAVALIFLFVLVSDIGYFISIAPLTRIYEDITCRRYFQESGQTLFLNGTSGSPDEAQCKIPEVQGPVAELFGYQTFLDSLVGIFLGLYFGALADRVGRRPIFTIGTVGAFLSSCWTLYVCWMEFPLRYVWFSSTFLILGGGSTVVNACLTMILTDATPAASRSRVFLYFTASNLGSEVIAPPIASYFIDSNPWVPLMIGLCCTGLTVSIAASVPETLSPKRKSVEAIDNPDGPTEEDVLHPTEVPAKDSPFKATIKHTLQSLNYIKSQHALFRLVCVFMISDFARQSMLFLVQYVSVRYRLTLGQDGVSAPFHGMSSRTSMGAQQRAQQRAPAGSARPAHHRSISSSHIPPPSPVRKDGLSDHNQPTDPADASTASSHPSTGSRHGATPRRTAGSRLRLELSNDANITPVPSTDSPLGTPSTHSAAPDSSTDVSGRGSPAFSRASHPDSTKMPMPHRRAPMQRFVVSSKTAVPATVPMKRDSKPKQYAIEVPLAAPRYLSTNKHDTVHRDPFNKGLFSGNADFFPWTGRHHEDEWSTEAIQKGTWDRGSQNETSSARLAVYPSLKQKTGLNALSTIFMGVLNQRRNRGQVTAPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVAGALVMGNELKWIRDWTIFVEQFIDSVVSSVGEPDWKRRATYSIRLATVLYSEHLLDRDHYLDWIVLGLENSSQAKLPMWILVAQTCWADVLRSRKPGRRLVFALLSHLNKIYNDPDRDILIPLSNQLSSLLKTLVAKNRESFIQPLQWLKYRECLAAFLPADERALQQAYRSINQRNSELLVSSTASPPVGGKEHLVKLLDATLHGKVNRELSSKCWSTSEDKTQVLRTVIEWVTSFHRPGLEKIYTATNLLRSWGSFRANTTGAILDTLDSIDRDDMVRKQAVYRLVTELARTGHFSVAQYIQWLIARGNCHSAADVEDSGPCASRLLVELPVYCLPDDRKSDRANLLRRAANYDVTDEARDTEIAIQCVNQTVGIPAANNVDGETLPTKPIPLRKLVNRIKSSSFALKSAVGAHLRDAIQGLLPPRLNTEVSLNVFTSIRTILEATGDFAMLGEIIKSCAKMSNIEVLAACVDTTNVNLQVLLAVGVADDVFTLYVERLKAVSREHGLVARPLLAALSSLAQRMPNQGDMAKNLQQELTQTDRSNPIDACSPVSDNMVSQATSPEGEVSEQIDKLLATGNSVDHPTMNRLFRNIVPRLEAGWNKLDASRRVYASLLARLRLFDTHHFDRLMSDWVSHIRSLKERPALLELLPLLVSLGCLTMVNVLHTANAAPVAANVNAVDSDPPRGSAIYLQELLQLILRKLPKQNPLTPEESYRFIVYQQSAKIEHSRALLLLIRNAVHEYSILRTRSTTTTLPLDDRSCQDDVLEALRVLVVANSAAAAEALSIKDLAPEASALIRTVAAKLLTPGDENTSSSFDKILGLANELTMPFCQLSLSMELSLPQNSRMSDEQQESQFDMFARAMDSAIEARNIVWTSMLPCLSDDITQHLRSQTHGRFLDMIPSSKTSNFAEMATSEDRIQLAKNLLGVIEAIISGQPPSKSAQLTSTLVDKLTDLWEIISAPTSSAAQDAVRKHWLPFLLRFVTLHSISSSSSLALEMSNQAASAGSPATAAGPSAIVNKVVSNAAAAAATTNHNNHEARARIVFVLCGILSALEAQQTLPLRDTKLVQQVFDISLLLVDALPDDMRLHCARSVLASHSAVSVSRAGTSDPRIYYLLSYPRPTAADNLMLAHRDRSAIPPSAAARGLGAMYGIGPTLQERYSQFVLRRWEALSEPTPNVGENDTSLSLGLFEAIKIQ
Length1910
PositionKinase
OrganismCordyceps confragosa RCEF 1005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Akanthomyces> Cordyceps confragosa.
Aromaticity0.06
Grand average of hydropathy-0.154
Instability index45.72
Isoelectric point8.63
Molecular weight210055.34
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transmembrane transporter activity	GO:0022857	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07179
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.50|      24|     263|     242|     265|       1
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  242-  265 (41.17/31.09)	VSIAASVPETLSPKRKSVE...AIDNP
  501-  527 (37.33/27.31)	VSSKTAVPATVPMKRDSKPkqyAIEVP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     291.34|      73|     263|     326|     402|       2
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  326-  400 (123.20/76.37)	LVQYVSVRYRLTLgqDGVSAPFHG.MSSRTSMGAQQRAQQRAPA.GSARPAHHRSISSSHIPPP....SPV......RKDGLSDHNQ
  593-  653 (77.14/39.83)	LAVYPSLKQKTGL..NALSTIFMGvLNQR.....RNRGQVTAPS..TFKP............PP.....RVtltdtkREVWLKDLAN
  657-  688 (30.34/16.38)	.....SLR.RLS.....RTIP.HG.IRGRTLL..DQCLNKNVPT.ERA.......................................
 1217- 1274 (60.65/30.99)	......................HG.LVARPLLAALSSLAQRMPNqGDMAKNLQQELTQTDRSNPidacSPV......SDNMVSQATS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     547.26|     218|     259|     698|     939|       3
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  698-  848 (177.58/146.17)	..............................................................................................NEIRAFKRKGVAGALVMGNELkwiRDWTIFVEQFIDSVVS...SVGEPDW.KRRATYsiRLATVLYSEHLLDRDHYLDWIVL.G.......LENSSQA......KLPMWilvaqtCWADvlrSRKPGRRLVFALLSHLNKIYNDPDRDILIPLSNQLSSL.................LKTLVAKNR
  849- 1112 (306.02/237.41)	ESF.IQPLQWLKYRECLAAFLPadERALQQAyrSINQRNS.ELLVSSTASPPVGGKehLVKLLdATLHgkvNRELSSKCWSTSEDKTQVLRTViEWVTSFHRPGLEKIYTATNLL...RSWGSFRANTTGAILDtldSIDRDDMvRKQAVY..RLVTELARTGHFSVAQYIQWLIArGnchsaadVEDSGPCasrllvELPVY......CLPD...DRKSDRANLLRRAANYDVTDEARDTEIAIQCVNQTVGIpaannvdgetlptkpipLRKLVNRIK
 1114- 1196 (63.66/31.97)	SSFaLKSAVGAHLRDAIQGLLP..PRLNTEV..SLNVFTSiRTILEATGDFAMLGE..IIKSC.AKMS...NIEVLAACVDTTNVNLQVLLAV...........................................................................................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.82|      61|     117|    1623|    1687|       4
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 1623- 1687 (92.38/71.36)	AEMATSEDRIQLAK.NLLGVIEAIISGQPPSKSAQLTST.LVDKLTDlweiISAPTSSAAQDAVRKH
 1740- 1802 (92.44/60.83)	AAAATTNHNNHEARaRIVFVLCGILSALEAQQTLPLRDTkLVQQVFD....ISLLLVDALPDDMRLH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.52|      36|     117|    1315|    1386|       5
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 1316- 1363 (48.17/88.54)	LDASRRVYASLLARLrlfdthhfdrlMSDWVSHIRSlKERPALLELLP
 1580- 1615 (66.34/28.51)	IEARNIVWTSMLPCL...........SDDITQHLRS.QTHGRFLDMIP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07179 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VSAPFHGMSSRTSMGAQQRAQQRAPAGSARPAHHRSISSSHIPPPSPVRKDGLSDHNQPTDPADASTASSHPSTGSRHGATPRRTAGSRLRLELSNDANITPVPSTDSPLGTPSTHSAAPDSSTDVSGRGSPAFSRASHPDSTKMPMPHRRAPMQRFVVSSKTAVPATVPMKRDSKPKQYAIEVPLAA
343
530










Molecular Recognition Features






MoRF SequenceStartStop




1) RIYYLLSY
1825
1832