<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07177

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGEASGRTDHDRPSTNVNGVVDQTGAPDVKGKGKTAASFSDPPRMNDLPDDIVHITQGFVPLSAFLTRLAQLTHNSVQEKMTELAKMPIPASAVNGGATNFTASAPDDTSAENLRKKAALLHFTQDMHAKWVKALVIMEWSRRAPHVSKLIDLKFHMDQLRIFYDTCVDSMVNVKRDLSYARMPAPDLKTALQILSTGSAPWIPDHQYIEPPPLTRREKLRWIKDLNTRLSLRLNLDDYDKIPYQFRNYEIGSGRVTFKVPDEFEVELTIADEDSEKQFWFIDFRFAFKPSALSLSEGLRNFLESYVNDSLARNGLEGCYQFLHELVLTAKITELKRQALQLSRTSWDGTIVVEPLNRALAIQYWSSRASATKSWVLIAINSGKKNGKMDAKSPSHLVAKWYRDNKEVTDVKLVLDVGNLSAESLLKEVIGRHIGYILQSIRDKLLEAPRFKQHESAMTLRISNRNPGNCMLTTQISHNNTTTLLVEPTTGIFAVKPQSKFSIQYEHQLNNGKNSADDGAACLENVRCAMMEDELHRRGNVLGWQTQKSPLTMEETKTITKMREWTRTIWMRKQGWGQSWYVAILLGLGGDEWWLLEANRNEPGRPVRFQARLPLSKGHPDLSYAFWSHLTIFATGMISQAVDMRELHRLRIKSRVSNSSDLALPQQIHLPSIQVALSAMFPNMVQDGGSKPAGRQSWANDVVTIRFKGIKSSDDSLTCVSEAVLRVRKPSKFAALKGTVDGNLSYNAKVGEFCLCVQHGMGEPVLALLKSRIQAIDRFVNFLEAMDKAKGSIVGELVTLKEIRFLYHQAGSGSDSKQWRITLDLSKDDIAIKIDYGNPHLRVVDLMQQLVNGDGGIGALMGWLPVSLQALEAISSIEARWEEPQHKRLGQVEIAMKTLSWLSLQYTVAAAGSSGAKKRVILQVRTKTRRGETWWHVWRDDDGSSDDAYGTALKAVWDNRGEGWMGLSTGAAARSEGGIVAMLLAVDDAMRSVALVDDGSTATGTQPSTTGTQPSTTNPSFTQPTTQSQNSGRDVVVLD
Length1041
PositionTail
OrganismCordyceps confragosa RCEF 1005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Akanthomyces> Cordyceps confragosa.
Aromaticity0.07
Grand average of hydropathy-0.351
Instability index34.16
Isoelectric point8.74
Molecular weight116057.88
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07177
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.80|      24|      50|     739|     764|       1
---------------------------------------------------------------------------
  739-  764 (36.64/37.89)	KGTVDGNLsYNAKVGEFcLCVQHGMG
  792-  815 (42.17/30.57)	KGSIVGEL.VTLKEIRF.LYHQAGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     474.68|     152|     222|     135|     349|       3
---------------------------------------------------------------------------
   28-  146 (139.13/105.16)	..........................APDVKGKGKTAASFSD......PPrmndLP.DdivHitQGFVPlsAFLTRLAQL.......THNS.VQEKMTELAKMPIP..................................................ASAVNGGATNFTASAPDDTSAEN.LRKKAALLH...FTQDMHA....................kwvKALVIMEWSRRA
  161-  371 (224.29/226.69)	QLRIFYDTCVDSmVNVKRDLSYARMPAPDLKTALQILSTGSA......PW....IP.D...H..QYIEP..PPLTRREKLRWIKDLNTRLS.LRLNLDDYDKIPYQFRNYEIGSG....RVTFKVpdefeveltiadedsekqfwfidfrfafkpsALSLSEGLRNFLESYVNDSLARNgLEGCYQFLHelvLTAKITElkrqalqlsrtswdgtivveplnRALAIQYWSSRA
  820-  926 (111.26/50.78)	QWRITLDLSKDD.IAIKIDYGNPHLRVVDL...MQQLVNGDGgigalmGW....LPvS...L..QALE....AISSIEA.RWEEPQHKRLGqVEIAMKTLSWLSLQYTVAAAGSSgakkRVILQV.............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.26|       9|      53|     943|     953|      10
---------------------------------------------------------------------------
  943-  953 (14.00/14.35)	DDGSSddAYGT
  999- 1007 (18.26/ 9.92)	DDGST..ATGT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07177 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVDDGSTATGTQPSTTGTQPSTTNPSFTQPTTQSQNSGRDVVVLD
2) MENGEASGRTDHDRPSTNVNGVVDQTGAPDVKGKGKTAASFSDPPRMNDL
997
1
1041
50










Molecular Recognition Features






MoRF SequenceStartStop




NANANA