<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07172

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMADAAENKPLRSDNSLLSEAENMFEDMGGDMFGDNDITEADFNFFDEQPDELGMDMSLDNIKRADAPTAIPIKAEEPALSASATVPIISEPVVFAKPELKHARSSQTEDGPQRGRDLQAKSVKRGSSPFDPDSVFKRLRAAISQQSQRAVNGGGLSKGYKAFGRVDFDSKMPMLNKKYEHGGFFDFVPHEKVTDKLEPGTIPKTDYFRRHSKAKAKAFAGSRRSSLAKSGNDLGSDHKLLNFDGDISDGDDSSTSSDNASNVSVKEPLSPVKSIVKQSLLGDDDAASYVTTSRDAELAEEPDEQLALELPRLSLLEGSDTSLFKYFTDPEPLSLDISLGDEDMIQVAQLVAEQAATGSLLLFNGHSDPGLVSAIEEDSRIEQLMGSRSALQALREAASSVFGTISPIGLKKLLEVQDGSLPGQGNRIQPRQVPSRDPNSEPIKPSNLYQIPCPHLEVRRADVKMSLLPTAVTFWENLGLAPSSGSKDIHAVCVCPKWTGMVDNAQTFLGRLKSAYETLKLGTFENMPLPTDMDDGVLLYGVDQISTARDATMMGHGSALLESMETLSSAMSDLEVVDTNVVVYFMYSASDPGTIVEACVAFQRFFESYRRRLSAKRESAKNEVVLQLVSADSVSSSTRMVVTASSELMKLCMETYDRCTLFGGSMPAPAIRLEQPLPRIIDFKLSPAPSSSLARENSCIHIAYARSIDGRWVTAAWTDDRGNEQTTAAYCLGRKGEAESRTMNDVANAIWETTIELISTWKVHYRIIMTKCGPTDEGEIDFWIDLARTEINASVTMIVMTVDTNPSLQLVPAPVKMPLQPLSMYTTPVSTPQASIVSPEASATPATPAKDAAAAAATPGGESTGDADVDSVLADVMDQTWGAIVHHRLNNAVGTASIQPALISGYLIKRSGPKAEDVPSMMEVNLVYTEATARTYEPLLREMLSYFRGLGTLARARGVVDRQADVRPWHVAAAEKALRALYILM
Length984
PositionKinase
OrganismCordyceps fumosorosea ARSEF 2679
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps.
Aromaticity0.06
Grand average of hydropathy-0.277
Instability index47.26
Isoelectric point4.91
Molecular weight106877.46
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07172
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.69|      11|      18|     661|     672|       1
---------------------------------------------------------------------------
  661-  672 (17.18/12.67)	FGGSmPAPAIRL
  682-  692 (20.52/ 9.87)	FKLS.PAPSSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.04|      36|     221|       4|      41|       2
---------------------------------------------------------------------------
    4-   41 (57.11/45.71)	AAENKPLRSDNSLLSEAENMFEDmgGDMF.GDNDITEAD
  227-  257 (46.22/29.15)	AKSGNDLGSDHKLLN.....FD...GDISdGDDSSTSSD
  258-  284 (34.71/19.83)	NASNVSVKEP...LSPVKSIVKQ...SLL.GDDD.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.96|      23|     137|      44|      82|       3
---------------------------------------------------------------------------
   44-   67 (37.10/42.28)	FFDEQPDElGMDMSLDNIKRADAP
  106-  128 (39.86/14.17)	QTEDGPQR.GRDLQAKSVKRGSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.62|      40|     221|     366|     405|       5
---------------------------------------------------------------------------
  366-  405 (64.86/41.79)	SDPGLVSAIE.EDSRIEQLMGS.RSALQALREAASS..VFGTIS
  408-  434 (25.19/11.63)	...GLKKLLEvQDG...SLPGQ.GNRIQP.RQVPS.........
  552-  574 (23.19/10.11)	..................MMGH.GSALLESMETLSS..AMSDLE
  589-  629 (48.39/29.27)	SDPG..TIVE.ACVAFQRFFESyRRRLSAKRESAKNevVLQLVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.80|      40|     142|     747|     792|       6
---------------------------------------------------------------------------
  747-  792 (67.39/55.64)	NAIWETTIE..LISTWkvhyriIMTKCGPTDEGEIDFW.IDLARTEINA
  890-  932 (58.42/35.80)	NAVGTASIQpaLISGY......LIKRSGPKAEDVPSMMeVNLVYTEATA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.45|      13|      17|     166|     181|      12
---------------------------------------------------------------------------
  166-  181 (21.61/19.06)	DFdskMPM..LNKKYEHG
  185-  199 (18.84/ 8.42)	DF...VPHekVTDKLEPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07172 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MADAAENKPLRSDNSLLSEAENMFEDMGGDMF
1
32










Molecular Recognition Features






MoRF SequenceStartStop




1) DSVFKRLRAAI
2) ENKPL
3) IPKTDYFRRHSKAKAKAF
4) SLLSEAENMFEDMGGDMFGDNDITEADFNFFDEQPDEL
5) YKAFG
132
6
201
15
159
142
10
218
52
163