<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07167

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAEGSETAANASGLFGPRDPVFRPWPVRDRTPTTIAEFVQRVKAQGGEFRQLTEAGLRAEIDEQQRKREAGEGEDDGDGDNDATAESLDASRGQHDKDDVDIAGGKPKDIEAMIAKRDEILMVLESALQSGLIAVDFVSLLLSKDRPTHAVQTLSPLLREKVGIGTLSAGRVANAAQAARALQTKNHGGGGGGGGSMSAAERQSLDETTRSNAQRLLDHKTECVGWQLLAMDRAAALLAAGRKRLRTEMRREERYWSEVVAVHDRGWGLSRMPGQRRVLRVKFGFSESATDLRAAGFAPLRRVKRGHVALDMAALGPPCALVVTLRRRPQGGSSAATTTTTTGRSVPPARLPATAALEDRIREARNTIYAKELWRELNREARQMVAHGVVFRDGALIFPVGGHTVGTITLEPLQLAATAAVADGADNEPPLDAILTELAETMTSSLHLFLAHGHRQHYRQRSVPTPPTDSTGAPPPTYFMLRPLLANQKYEKAIEHLAQFLADLCSILHGVGQTGARFMLYERPLASFLPPPPPPPPPPAGAASADGIKETAARTNQRQSASEGLCTGFLAPREFTFELTLGPDVRLSIRSRTTVAPLKTQYLVQLVKPSAAPAPAPHAPDSLSASENNHDINRLLSQLFPPADNYGTLRDVLDYVGDVVARVLTARARSFANAAEAQADTGVAWGTAVDGMALLRTNSPFRMLRFCVVPTNAVTKLDALVDELANELAGEQTSGDRNGSGGSGSARHAWFGGNDDNDDVIVGDNNEDDNDQVQSFQSDSNADSPLQQLVRPELRMYASWPLSHADAAIYRRWAWNADAEASPGASLHDLVEGCVRGDLMPATEPKAE
Length848
PositionHead
OrganismSporothrix insectorum RCEF 264
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.05
Grand average of hydropathy-0.386
Instability index47.28
Isoelectric point5.89
Molecular weight91305.43
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07167
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.03|      53|      67|     329|     393|       1
---------------------------------------------------------------------------
  309-  377 (70.90/45.35)	ALDMAALGppcalvVTLRR....rPQGGSSAATTTtttgrsVPPARLPATAALEDrirEARNTIYAKELWREL
  381-  438 (87.13/44.99)	ARQMVAHG......VVFRDgalifPVGGHTVGTIT......LEPLQLAATAAVAD...GADNEPPLDAILTEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.26|      38|      67|     464|     502|       2
---------------------------------------------------------------------------
  464-  502 (65.40/43.33)	PTPPTDSTGAPPPTYFMLRPLLANQKyEKAIEHL.AQFLA
  533-  571 (63.86/37.25)	PPPPPPPAGAASADGIKETAARTNQR.QSASEGLcTGFLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.37|      23|      23|      70|      92|       4
---------------------------------------------------------------------------
   70-   92 (38.16/23.20)	AGEGED.DGDGDNDATAESLDASR
   94-  117 (35.21/20.80)	QHDKDDvDIAGGKPKDIEAMIAKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.85|      63|      67|     619|     685|       6
---------------------------------------------------------------------------
  619-  685 (94.58/73.35)	APDSLSASENNHDInRLLSQLFPPADNYGTLRDVLDYVGDVVARVLTARARsfaNAAEAQADTGVAW
  688-  750 (106.26/69.43)	AVDGMALLRTNSPF.RMLRFCVVPTNAVTKLDALVDELANELAGEQTSGDR...NGSGGSGSARHAW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07167 with Med17 domain of Kingdom Fungi
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