<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07165

Description "Mediator complex, subunit Med12"
SequenceMTSRTPTGVQPRQPQRGLGSTQQVQRPTNTIQRSVSASQQQFLTTSPSRRDSTAPPDSNPDTTDISSTHHASTPRRQGSRLRLELSSDLVPSGPSSAMASPQSLTPSRMMPLSDATETGSASPALSRASQQDGDNPALPMPQRRLPTLAQSVRSNVPRTASAAPPKKDTRPRPYTVEVPAVAPRYATASRPDLNHRDPFTKGLFSGHADFFSWSGNHHEDDWSTEAIQKGTWDRGNQNEASSARLAIFPALKQKSGLNALSTIFMGVLNKRRHRGQITAPSTFKPPPRVTLTDTKREIWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKDVPAERAVWLAKCVGANEIRASKRKGASGAFVLGGEMKWIRDWTVFVEQFVEAVVSTFGEPDWKVKVTYAIRLAACFYSEQLLDRDHYLEWIISGLETSAQSRIPMWILIAQIYWSDLLQLRKCGKRLVFALLNHLHNIENDPDRDILMQLSSELSTLLIGLAKTNPESFICPPAWQHFAETLRRVTPADDAAAQAAYGIIKLRNARLSVTNTTSLPEGRQYLVQLLDSTLQGKGGPDLSAKCWATTENKSEIIKTAVEWATSQHRPRLAKLYVATELIRSWELQGVHATLEILDILGDVAPTDKIKKKAMIRLVAELVRRGNFSVPRYLQWLIGRGGLHTAQEIDPVDGPCASRLLVELPVHCLSGELASQRANLLRRAGNYSVSDEVDNTRSALACVDVAVGLTAHTQPPNVPRKPLPLRKLLRMASNSSRAVQSAIGHHLFDTVTSRLSQKSGFVMTLPKFCSLRDIMESIEDFSMFGGILKSCCNCSDPEVVAACVDTLNANLEIFTAMGCAETLFDMFIERLKTISREQGVVTRSLLAALSSLAPRVPQREALAKQLSMELAQNDRSNALDACSPVSDSMAAQAQTAEGEISDQIDKLLASGNVIDHPTMNRLFRYIAPKLEAGWVKLDENRRVFASLLSRLRMLDAPHFDKLMADWVGHVRTLKSRPSLPELFPLLVVVGCLSITTVLHTSNISPLETGASTEATMPMSATYLQELLQLMIAPLPRTAILEPEEAYRFRIQQRIAQSEHAKPILLLIRNALVEYAALQPEETSELPLDGPVFQECLLETMRLLVVADSANVADVLSMGTLPSGAMALAHRVVTKLLLPEDNSEQHPSFDKILSLANDLTIPFCQLKLNLDLATNLGGSSGGRDEEGSVRFERFAKAMDHAIESQNIMWTSMLPCLSDDITQGLNIEVHTRFLDLMPSSKSGGTAHDVMHPERTRLAQNLLGVIEAIISGQPPSRQSALTPSLADKLADMWEMIASRDAYHHQPDHGMEILDDWLPLLLRFIILHSASPEASDASLLSSSSTSTPGAANAQKALPAHTTTTNHEARARIVVVLCGLLLELESLPCEVTGSLGQQVLDIAMLLADGLPDDVRVQCAKSMLFLPGSTASTSTSSDPRLYYVLSTPRPSAAAENLKLLQRDRINAPPPPPPQPQPHAHPLPHTSAQQQQQQQQRGMGAVHGLGSYSSSSSSTTTMMMMERMTPFVLRRWEILSEPTPNVGENDTSLSLSLFEAIKLQ
Length1582
PositionKinase
OrganismMoelleriella libera RCEF 2490
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Moelleriella.
Aromaticity0.05
Grand average of hydropathy-0.228
Instability index49.48
Isoelectric point7.26
Molecular weight173800.75
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07165
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.99|      28|      29|     877|     904|       1
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  877-  904 (45.17/30.92)	ALSSLAPRVPQREALAKQLSMELA.QNDR
  907-  935 (41.81/27.97)	ALDACSPVSDSMAAQAQTAEGEISdQIDK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.04|      24|      25|     152|     175|       2
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   90-  113 (35.87/17.52)	VPSG.PSSAMASPQSlTPSRMMPLS
  152-  175 (44.69/23.90)	VRSNVPRTASAAPPK.KDTRPRPYT
  178-  200 (41.47/21.57)	VPAVAPRYATASRPD.LNHR.DPFT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     355.02|      98|     189|    1233|    1336|       3
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 1233- 1336 (160.02/98.49)	QNIMWTSMLPCLSDDITQGLNIEVHTRFLDLMPSSKSGGTAHD.....VM..H.PERTRLAQNLLGV...IEAI...ISGQPPSRQSALTPSlADKLADmwemiASRDAYHHQPDHGM
 1354- 1418 (49.37/19.17)	SASPEASDASLLSSSSTSTPGAANAQKAL..........PAHT.....TTtnH.EARARIVVVLCGLlleLESLpceVTGS.....................................
 1421- 1521 (145.63/76.30)	QQVLDIAML..LADGLPDDVRVQCAKSMLFLPGSTASTSTSSDprlyyVL..StPRPSAAAENLKLL...QRDR...INA.PPPPPPQPQPH.AHPLPH.....TSAQQQQQQQQRGM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.31|      77|     508|     448|     597|       4
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  516-  597 (115.32/59.22)	LRRVTPADDAAAQAaygIIKLrNARLSVTNTTSLPEGRQYLVQL..LDsTLQ...GKGGP.......DLSAKCWA..TTENKSEIIKTAVEWATSQ
  630-  720 (110.99/69.61)	LGDVAPTDKIKKKA...MIRL.VAELVRRGNFSVPRYLQWLIGRggLH.TAQeidPVDGPcasrllvELPVHCLSgeLASQRANLLRRAGNYSVSD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.66|      33|      34|    1053|    1085|       5
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 1053- 1085 (55.21/31.87)	QELLQLMIAPLPRTAILEPEEAYRFRIQQRIAQ
 1090- 1122 (54.44/31.32)	KPILLLIRNALVEYAALQPEETSELPLDGPVFQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.73|      22|     508|     448|     482|       7
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  460-  482 (36.56/46.57)	RLVFA.LLNHLHNIENdPDRDILM
  970-  992 (36.18/14.30)	RRVFAsLLSRLRMLDA.PHFDKLM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.06|      33|      35|     383|     417|      10
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  383-  417 (45.90/34.14)	FVEAVVSTFGEPDwKVKVTYAIrLAACFYSEQLLD
  421-  453 (59.16/33.34)	YLEWIISGLETSA.QSRIPMWI.LIAQIYWSDLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.97|      33|     227|     936|     969|      11
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  936-  969 (52.73/42.94)	LLASGNVIDHPTMNRLFRyIAPKLEAGWVKLDEN
 1165- 1197 (57.24/40.80)	LLPEDNSEQHPSFDKILS.LANDLTIPFCQLKLN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.23|      29|     116|    1008|    1039|      12
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 1008- 1039 (44.51/35.35)	LPELFPLLVVVGCLSITTVLhtsNISPLETGA
 1125- 1153 (47.72/29.31)	LLETMRLLVVADSANVADVL...SMGTLPSGA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07165 with Med12 domain of Kingdom Fungi
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