<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07164

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTVDAETNVLLVSNIASVAYRFYEPSADLKQTFFSNALVIETTLREQGRIVSFDATRRGLWYFHIRRSVGAESQGPTELGATAIVNGQSLVSTKHGSMEPSQWHKSLAPEPSTHRPNQNSSGHAAQLQLTGAQQDHEATAITEQTEPRLSNGFTPRVLYESFIGALLLTICSSFCSKSEAVPLNFRTVLLPALKASESATDRWIGEKAQALGTLKCYMISTGSLILSFSVTVCPGLASLEDILSSNSNPIGNNILAAPFGVMTNEEQLPSSHSTGAPLAHTPTIQSLAQRSPSNVNSSFWKQACLTIFQLRGVPGAALRECSWVNLLVSKPKLQDIKPENGRAAQSTISIPWPGSLCFRKKAVELSATNRISDTIVVGHDETHDPLGDARGWLSSANEREERISKRHAERSAAGAKENSAIDTRLGKINAPSPVTMRRPSTTGGNAVYPTPPDAIQNLNGVTPSMDGNLSSPGHPLSVVADIDIDCEPPGEDNSVHQIDDEMTEAADGKPLRSDNNLLSEAENIFEDMGGDVFGDNDITEADFSFFDEQPDEMGMDMSFDSMKGSRVPSALPIKAEEPVASASINAPPSAESAVFAKPELKHARSSQPEDAPQRDRDHQAKSVKRGSSPFDPDSVFKRLRAAASQRTLRGDYGVGLSRGFKVFEKVDFDSKMPMLNKKYEHGGLFDFVPNATDTDKLEPGTLPKTDYLRRHGKTRAKQQADSRRPSIVKSSNDPDTQLLDHQLLNLDGDISDGDDSSSDSDIASNLSVKEPASPVKSTVKQSILGDDDAASYVTTGRDQDLAEEPDEQLAFELPRLSLLDGPDTSLFRYFTDPEPLSLDISLSDEDMIQVAQLVAEQAAAGSLSIFSGHSDNALATVTEEDARIEQLTGTRCALQALRDAASSFLGTISPIGLRTLLEVQDGSLTGQGNRVQPRQIPSKDPNSEPIKPSNLYQIPCPHLEVRRADVRMSLLPTAVTFWENLGLAPSSGSKDIRAVCVCPKWTGMIDNAQVFLGRLKSTYETLKLGTFENMPLSAGLDDGVLLYGVDQISTAPDATMMGHGSALLESMETLSSAMSDLEVVDTNVVVYFMYSTSNPGTIVEACMAFQRFFESYRRTLVAKRESAKNEIVLQLVSADAISSSTSMVITPSSELVKLCMETYDRCTLFGGNMPAPAIRLEQPLPRIIDFKLSPAPSSSLARENSCIHIAYARSIDGRWVTAAWTDDRGNEQATAAYCLGHKGEPETRTMNDVAHEIWQTTVELISTWKVHYRIIMTKCGPTDEGEIDFWVDLARTEMHASVTMIVMTVETNPSLQLVPAPVRMSLQPLSIYTTPVSTPQANIVSPEASAAPATPARDTAGAVATPGGESNGDADVDSVLADVMDQTWGAIVNHRLNNTVGTTSIQPALISGYLIKRTGPKAEDVPSIMEVNLVYTEASARTYEPLLREMLSYFRGLGTLARARGVVDRVTDVRPWHVAAAEKALRALYILM
Length1489
PositionKinase
OrganismBeauveria brongniartii RCEF 3172
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria> Beauveria brongniartii.
Aromaticity0.06
Grand average of hydropathy-0.299
Instability index45.89
Isoelectric point5.00
Molecular weight161467.58
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07164
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     589.58|     142|     143|     506|     648|       1
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  381-  479 (85.35/47.88)	.....................................................DETHDPLGDARGWLSSANEREERISKRHAERSAA.GAKensaidtrlgkINAP...SPVTMRRPSTTggNAVYPT...P......PDAIQ.NLNGV....TPSMDGNlS.SPGHPLSV...........
  506-  647 (239.57/148.35)	AAD....GKPLRSDNNL.LSEAEN..IFEDMGGDVFGDNDITEADFS....FFDEQPDEMGMDMSFDSMKGSRVPSALPIKAEEPVA.SAS...........INAPPSAESAVFAKPELK..HARSSQ...P......EDAPQRDRDHQ....AKSVKRG.S.SPFDPDSVFKRLRAAASQR
  648-  774 (132.56/81.48)	.........TLRGDYGVgLSRGFK..VFE.............KVDFDskmpMLNKKYEHGGL...FD.....FVPNATDTDKLEP....GT...........L..PKTDYLRRHGKTRAK.qQADSRR...PsivkssNDPDTQLLDHQllnlDGDISDGdD.SSSDSD.IASNLSVKEPAS
  790-  911 (132.09/79.14)	AASyvttGR....DQDL.AEEPDEqlAFELPRLSLLDGPDTSL..FR....YFTD.PEPLSLDISLSDEDMIQVAQLV...AEQAAAgSLS...........IFSGHSDNA..LATVTEE..DARIEQltgT......RCALQALRD......AASSFLG.TiSP.................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     397.36|     128|     143|    1155|    1297|       2
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 1155- 1297 (205.85/155.45)	LCMETYDRCTLfggnMPAPaIRLE.QPLpRIIDFKLSPAPSSSLARENSCIHIAYARSIDGRWVT.AAWTDDRGNEQATAAYCLGHK.GEPETRTMNDVaheIWQTTVE..LISTWkvhyriIMTKCGPTDEGEIDFW.VDLARTEMHA
 1304- 1437 (191.51/111.49)	MTVETNPSLQL....VPAP.VRMSlQPL.SIYTTPVSTPQANIVSPEASAAPATPARDTAGAVATpGGESNGDADVDSVLADVMDQTwGAIVNHRLNNT...VGTTSIQpaLISGY......LIKRTGPKAEDVPSIMeVNLVYTEASA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07164 with Med13 domain of Kingdom Fungi
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