<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07163

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMTVEGSKVQALVSDALKVDAIEEAFNDFLVQRKDEGIKYSALEKEIIAMINDPQGESQDTVLPQLVAVISSVSSDSHSKLLFKLLESVVNANIATARKVCDTLLVNEKLTPANPLLWQGSFYLIKKIVCHVDYKGVREIMKTCLEKAQLLPSRFSTSEYPNVTALELTLKHILDRQVCLLPAYFIVNEIRKMYPENKDWPHWKLAGLLSEVVDSFRPLVQMLSPIGRPLMFPVVDPSAHGVHHSWKLEQGTLKLALKGNLPYEKEYTEPQTRLIRYVLEQPYSREVLCGMLGLQKQHKQRHAVLEEQLVELLVQAMERAENTPEQDSDAADELGVSHWLWHHLSSQIIYFVLFQFASFSHLVTLLHEKLAERKLRKGRDQLMWVLLQYISGSIQKNPLAEFLPLLRLYDLLYPEREPLPVPDYTRPICVHQMAVACIWIHIVKKAQTEQQNAQKEIAAASAAAAGPGGIAPSPATAAGGKTDSRAFTTLLQRHFPQALKNHQEFLQHNALNPPSSAPSGDYRVALLCNAFSTTLDCLARPMGSLMESLHGNLSQKGSGNAGGGAGGMPNTGPISPIPLAFLDALTVHAKMSLIHSIVTHVIKCAQTKMNVPLAPALVETYSRLLVYTEIESLGIKGFITQVMTSVSKSQAWGIFHTLVEMFTFRVHHMQPQYRIQLLTLLHSCAVPQQHQTQLTLCVENAALRLIGLLGAAEMQPCYSRSAADIKPLFSSDSEELNRALILTLARVISVAGCETQHSGWYKDLLTLIQQQTPHSWSSNTRDCFPPPLAEFFGQAANQPVKESKQQLKQNIEEEHRKVLAMNPDDWPAHFSPQSNNPPFFLCLLWKQLLETERINPVAYKCIERIGARGLGSHLRTFCDFLVYEFANSGKGQHVNKCIDVLNEMVWQYNVVTIERLVLCLALRPLEGNEAQVCCFIIQLLLLKTPQFRSRVQDFVKDNSSEHWRQNNWHEKHLAFQRKFPERFGPPESVLETIGQGGSYQSLPTYFGNVCLRFLPVFDITIHRFTEIPPVTKSLETILEHLGCLYKFHDRPVTYLYTTLHYYERKLRDRPLLKRKLVSSIMGSLKDVRPQGWALSEAYLSYSIRPADDLNWLPELDYYVKLVGRLVDTTAGRSPFPFPAMDWRFNEFPNASCHALYVTAVELLALPASPAIVANALMDVVLQGYNLLPVSEATPVESWVNAVGLLLTYLPESYWSVLYDRIVELLSGPQLSSYTYPCSPLHLFHFSTVVGQGLDAPFVLLLAVAHAFFTHANIGQMGGLPQFVKDRLHPLIRTEEQYLWLCHLIGPTLQRFSVDKPKCVFDLTVELYELLEQVDKNVSEIRMIDPICDLLYHIKYMFTGDQVKTEVEQVIRNLKPPLRLRLRFISHLNPQ
Length1389
PositionTail
OrganismDaphnia magna
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.09
Grand average of hydropathy-0.075
Instability index45.17
Isoelectric point6.83
Molecular weight157097.95
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07163
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.03|      19|     466|     123|     147|       1
---------------------------------------------------------------------------
  123-  141 (33.70/34.84)	LIKKIVCHV.DYKGVREIMK
  172-  191 (28.33/12.99)	ILDRQVCLLpAYFIVNEIRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.33|      50|     623|     284|     346|       2
---------------------------------------------------------------------------
  284-  346 (71.01/75.32)	REVLCgmLGLQKQHKQrhavlEEQLVELLVQAMerAENTPEQDS.......DAADElgvsHWL...WH..HLSSQ
  914-  975 (78.32/48.30)	RLVLC..LALRPLEGN.....EAQVCCFIIQLL..LLKTPQFRSrvqdfvkDNSSE....HWRqnnWHekHLAFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.24|      32|     142|     686|     722|       4
---------------------------------------------------------------------------
  686-  722 (51.96/46.32)	PQQHQTQLTLCvenaaLRLIGLLGAAEMQP....CYSRSAA
  831-  866 (55.28/37.42)	PQSNNPPFFLC.....LLWKQLLETERINPvaykCIERIGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.56|      17|     151|      65|      86|       8
---------------------------------------------------------------------------
   46-   62 (28.33/10.09)	IIAMINDPQGESQDTVL
   65-   81 (25.23/17.36)	LVAVISSVSSDSHSKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      15|      18|    1083|    1100|      10
---------------------------------------------------------------------------
 1083- 1100 (18.52/17.48)	LKDVRPQGWaLSEayLSY
 1102- 1116 (28.86/14.21)	IRPADDLNW.LPE..LDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.38|      27|     302|    1015|    1075|      11
---------------------------------------------------------------------------
  352-  381 (38.92/11.02)	LFQFA..SFSHLVTLLHekLAERKLRkGRDQL
 1043- 1071 (47.46/21.51)	LYKFHdrPVTYLYTTLH..YYERKLR.DRPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.98|      22|     302|    1015|    1036|      12
---------------------------------------------------------------------------
 1015- 1036 (37.77/28.42)	VFDITIHRFTEIPPVTKSLETI
 1318- 1339 (35.21/25.94)	VFDLTVELYELLEQVDKNVSEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07163 with Med23 domain of Kingdom Metazoa
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