<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07161

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMGGQLAATPSPVSPPYPHHLHHQHSHLSHSIPAATHQQNQALHQVLSSRMGLSGSNNKRNSDGRGSSDCNDNLTGGGLGDSSYSGISQTHPHITSVNNAKKSRRASDLMMMDHVSSGSHHHLKSSVDGNSSCRSTPLTPLSSKSGGSQDGSSSPGTGASPSLFHQQTSSFRTPSAMMSGMMMAGSSVNDPTSVTAYHQTAPTAYYQQPYYHHLYPNPHHQPHHHHHPGYYQTAHHHHHHQGWTTDFTAGLHHHHHPGASVVPSVPMALPSSAVISSATTITPASAAVATAYQHSFPLTPDGSCGNPAGTAAGENVTGSNSAGVTSSAMYETNALQSNKGNNKDSMGSEDHNQQQQRQQDSYSTIQADGVTAVDNGQGLIQQQSESGDHHAPSYYTNVGNAFTPCSTAINLSVKCSLEAPPSTITGSENGDYNGPNSSDPYTITVQQHKETKLNSSLQPEEQTDPLDFSCGGGSNSDELIQQQQHSENTDVYNGDTASAAAAKAAAHSYAFGRPLHADYSAAERSFYYRDTLGYNGSQTAVSYNGYGSSNGPDPAAYQCSSFANGNDTNFQYGGSPVATPASPMLTSACYTHPARVGATAGSTTASLIFGVSSSAHDKSSDSSSLCILRGGSSENGKMAMLAANAATATGMTQNQELKCPTLGCDGSGHTTGNYATHRTLSGCPRASTTGTNSRSRTNTRDTSTEPLRCFLNFEQVIALSTDGYNQIQNSSFPGIDDYMARKYRIPTPLPDVIYIRFKIAKRRLPKSKSGIVAIISLSYWCLFSCIYSGLFPLVKMSAALENLENQLELFVENVRQVKIIVSDFQPQGQSVLNQKINSIVQGLQEIDKLKSQVQEVHVPLEVFDYIDEGRNPQLYTKDCMEKALNKNEQVKGKIDSYRKFRAHLLEELSQVFPNETMKYRTARGDDVNRIQ
Length930
PositionMiddle
OrganismDaphnia magna
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.07
Grand average of hydropathy-0.627
Instability index40.56
Isoelectric point6.54
Molecular weight99852.37
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07161
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.80|      12|      16|     230|     241|       1
---------------------------------------------------------------------------
  214-  225 (28.56/12.94)	YPNPHHQPHHHH
  230-  241 (27.09/11.90)	YQTAHHHHHHQG
  246-  257 (24.14/ 9.82)	FTAGLHHHHHPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.85|      15|      16|     122|     136|       2
---------------------------------------------------------------------------
   93-  107 (17.42/ 6.26)	ITSVNNAKKSRRASD
  122-  136 (24.90/12.69)	LKSSVDGNSSCRSTP
  140-  154 (22.52/10.65)	LSSKSGGSQDGSSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.48|      11|      16|     660|     671|       3
---------------------------------------------------------------------------
  660-  671 (19.08/13.45)	TL.GCDgSGHTTG
  678-  689 (18.40/ 7.47)	TLsGCP.RASTTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.45|      16|      16|     304|     319|       4
---------------------------------------------------------------------------
  304-  319 (26.44/17.22)	GNPAGTAAGENVTGSN
  322-  337 (25.01/15.80)	GVTSSAMYETNALQSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.98|      16|      16|     499|     514|       6
---------------------------------------------------------------------------
  499-  514 (24.49/11.78)	AAAKAAAHSYAFGRPL
  516-  531 (24.80/12.03)	ADYSAAERSFYYRDTL
  534-  549 (22.69/10.36)	NGSQTAVSYNGYGSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.15|      17|      35|     433|     449|       7
---------------------------------------------------------------------------
  433-  449 (30.93/18.48)	GPNSSDPYTITVQQHKE
  470-  486 (28.21/16.16)	GGGSNSDELIQQQQHSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.72|      23|     294|      60|      85|       8
---------------------------------------------------------------------------
   60-   85 (37.50/24.86)	NSDGRGSSDCNDNLTgggLGDSSYSG
  341-  363 (43.22/20.80)	NKDSMGSEDHNQQQQ...RQQDSYST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.54|      34|      36|     553|     588|      10
---------------------------------------------------------------------------
  553-  588 (58.17/32.61)	PAayQCSSFANGNDTNFQYGGSPVATPASPMLTSAC
  592-  625 (56.37/26.31)	PA..RVGATAGSTTASLIFGVSSSAHDKSSDSSSLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.16|      45|      52|     806|     855|      11
---------------------------------------------------------------------------
  785-  837 (58.20/46.33)	IYSGLFPLVKMSAALENLenqLELF..VENVRQVKIIVSDFQPQGqsvLNQkiNS
  838-  887 (64.96/38.47)	IVQGLQEIDKLKSQVQEVhvpLEVFdyIDEGRNPQLYTKDCMEKA...LNK..NE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.37|      24|     125|      32|      55|      12
---------------------------------------------------------------------------
   32-   55 (42.12/22.72)	PAATHQQNQALH..QVLSSRMGLSGS
  160-  185 (39.25/20.69)	PSLFHQQTSSFRtpSAMMSGMMMAGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07161 with Med10 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATAYQHSFPLTPDGSCGNPAGTAAGENVTGSNSAGVTSSAMYETNALQSNKGNNKDSMGSEDHNQQQQRQQDSYSTIQADGVTAVDNGQGLIQQQSESGDHHAPSYYTNVG
2) MGGQLAATPSPVSPPYPHHLHHQHSHLSHSIPAATHQQNQALHQVLSSRMGLSGSNNKRNSDGRGSSDCNDNLTGGGLGDSSYSGISQTHPHITSVNNAKKSRRASDLMMMDHVSSGSHHHLKSSVDGNSSCRSTPLTPLSSKSGGSQDGSSSPGTGASPSLFHQQTSSFR
3) SLEAPPSTITGSENGDYNGPNSSDPYTITVQQHKETKLNSSLQPEEQTDPLDFSCGGGSNSDELIQQQQHSENTDVYNGDTA
288
1
415
398
171
496










Molecular Recognition Features






MoRF SequenceStartStop




1) YYHHLY
209
214