<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07136

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMLENGMNGSMQVDQLDVDDLFGDGVGLSLHTARPPTKHLRQRVDELRTRGCCQGVAWSRSGAIASISPDGKTLEARFLRSHPDDGNWGLSEPTKVDLITINASSPIVHLAWASTASPELAVIDATGRVAILTYSITLNRPFATRKWDHDPSDDLHAIVGSYWLPLAPQAKQYYVSHGPAVKDGNQYRYESSFVHAYGPWHPNPSKSALLCVTTNGHLKMFWAQNNNKIEETTLELESVNSSDDLITHAALHSDKSNLWVALATTSKQLRLVRVGINWGLPQSQSDNKPPPGSQALNPTMQEKHVAISSWLPSGSSTTPIDSAANQLTHLEILPSTLDHTGQGWAPLIILAVRTYLPTPSTPYQETQSIIDKWEVLNDQAQSLHPAFEQLGSRRNSTGAAPAPTSRLKKHESVVVNKVIVGVHSLQYGRVICLAFSDGSVEYRDRFTLQEIYNEMNLDRVMTLNQVGFTFQDESPCLQMAFSPTNCSIVKIQDDGKVKWNKLHYPLGDIGNSSQDAPYAATLAALTVAASTATFNNINYDDILAVARPYADKKRFTFDWINEIVRMLKVPVDYSEDTHHDSLVRNSSLQMCLSILNHLGYKGMFQPRSFGGKFAMLALNARNVVILITIASNTPVNIREKLSPLDEHEVVDALAGCAKWSLDLLSWLTDSLFALLDDPQFLALLTPQRFSEMSTYLQSRADVSLHLLLCSSTRGFLSAVCRRILHLEILSNRAIEFYERRAAMQNATDPSSQGKSLHVVLYKAYQKMQRVTSSSLIKVQEFDRLLTVLNNDIRSAYQSSLASLASKNPPGAGGQKAMDAQIKNAQIHCELNMLLASSPPPAFLPVLLKFFNSDLKTYRAQADPSKLFFADFDLLEIDDDRRALAARKAKGRFIDVFKRVELAAPPARGTKEGDEAKLAQWRRCVRCSAVMEDVFGSRPGFTFVLAQQRKCSCGGHWGLLPKGALMI
Length968
PositionTail
OrganismColletotrichum tofieldiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum spaethianum species complex.
Aromaticity0.08
Grand average of hydropathy-0.223
Instability index43.31
Isoelectric point7.61
Molecular weight107234.91
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07136
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.05|      28|     157|     673|     703|       1
---------------------------------------------------------------------------
  673-  703 (44.92/35.99)	LFALLDDPQFLALLTPQRFSEMSTYlqsRAD
  835-  862 (50.13/32.05)	LLASSPPPAFLPVLLKFFNSDLKTY...RAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     308.12|     100|     146|      99|     204|       2
---------------------------------------------------------------------------
   69-  115 (23.72/ 9.22)	.......................................................ISPDGKtleaRFLRSH.P..DDGN..................WGlSeptkvDLITINASSPIvHLAWA
  116-  225 (168.72/104.51)	STASPELAVIdatgRVAI...LTYSITLNRPFATRKWDHDPSDDLHAIVGSyWLPLAPQAK....QYYVSHGPAVKDGNQYRY....ESSFVHAYGPWH.PnpsksALLCVTTNGHL.KMFWA
  265-  348 (115.68/61.06)	ATTSKQLRLV....RVGInwgLPQSQSDNKPPPGSQALNPTMQEKHVAISS.WLPSGS...........STTPIDSAANQLTHleilPSTLDHTGQGWA.P......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.43|      23|      24|     905|     928|       5
---------------------------------------------------------------------------
  905-  928 (40.64/29.29)	A..PPARGTKEGDEAKLAQWRRCvRC
  930-  954 (38.79/23.25)	AvmEDVFGSRPGFTFVLAQQRKC.SC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07136 with Med16 domain of Kingdom Fungi
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