<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07135

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMVPNFSLLEHHPEYLVAQRQAIENCIETISRIRALASPDPCQQHVRFATLRNQLYRIALQCDLQLGDTGPILPPGLSSSGGIAWRLSADCFSVVISAIPADGYSLPPGTTPPEDYPVSVAAVHFEFNQDKPIECSVLVEDLKKRNYNSLLKHVKNLILLYDLPGEIAQRCRAYLCLQALEQDLLMLSTAVGNRKSNAVTPQSLEIPGLSWKNPTSPSEVSCLAQSINGSAVGQVIQRTGGVFTVLTYFVSAVQRAIAMSHAPKPPARSDPEAGMLGGFCASVGLRATANANQHSLPLVSLVNIIKDADGYNIAQFTNADNITRVNIAAEFFLRLHPPLLFDVESISAIEAITKIPMDSLKQNEPLPLHHLLLRQHNQEGLSSIDVHMTLPNKVQHAYHIVSNNLRGYVVNEIAFTCPSQLPPLVQLLRRKAAWLSFVESFLLHPRKPAVKDEDLTYRFCVNLPSQTGVLINFQHPLCSRRQVKGNVMIHSVTFIIHNLRAFSTELPNLVSIRMGDLGVSEAHVLGAVLPDGFLSDPNQDQIKENGSDDKYDPTGILTRSHSLPVALTWLLLQLGCPVVRMLTSTFPSKSATSNGNCKTTKPTGQRRPAVCLARARNALHLSDDASADGLLAGADRLSEKSLQDAERLFLGDGSEGGSGILYDPTAGTTPSWPVLQPSQPLPMMPSQQFPSRPLLPPGVMATTPPVGVTSDQLSVPTPKGLEDAFPSPALSSNNQSFRSIPVIPGVMTTSSTSLFGQPMKPPISYSAASTPSSVGFKPQTPASCGGSMLVSLLDEDNPPQSLPPPPHVGSSALPPNRILSSPVTATTPIPSSPITAQVPNSNHSTPLTLLPAYPKSSGSSDVLSHLLTSTSNIGVSSTNTTPVGVNSSANSSTQSLPPVLKSTTNSETGVSKKGRKRRVDPSMGGFISTLPTRAAIMDAIKQPAKPTPSKPTALAKESVYDFEDCPPSTNIALPPPFPPPKPFAFSDVSAPERTAERKSGLKFVIKTNRSGTGGGLTAAAGAATTPTENSAVVTKPRTKAVEGKPFALFKQMQQQQQPSTSSQHPKKERKRRVSSKNKEVQPSLVLSISSPKVFPSAPIVTPTPSPKKHGFVKGKPGRKKTLSTSSEPKRNRLISSDEPSVESGAVAPSSGVSGVGSSGGGNSTNRLIKGYKIPKVRKLPSPPPNNSPPVTSQSTNQEEAVTGRTEVTATTTTMSTALPPPPPPAQAASSAMSTITTKSQQRSLLFIVENLKRAVVESSTAPQMHQQQTSSAAVVELARSSTEASGDATNVAEDTVSADSNDNLFEKFSSASTPTKGGTPSIAPLPAKRFKVTPTPGAGVYDLNDVNLNCRPPEEDVVAVAGVGALASGTSEVEGDREESGDMGATLFGQDGQSDSQTPPASLEEESAAGGGLIKAPTDTPDSPTESISAKAFVASSKIIPVSQEAPPSGHTPSLPTGTVSNSAAAVASSSSSFFNKSISSGRPTSGTLRGGMARGAAGPRFNYLRGGWSGRPYGSPMIPRGGGGGGGAGRIPLPPWGGGPSGPPQPPPGPGGGVGGSGGWGLPRGGGPLYRIGGGGSGVGVGRGGGVSAGGSGGGGPFCGGGNRQAPPKT
Length1610
PositionMiddle
OrganismHydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Taeniidae> Hydatigera.
Aromaticity0.05
Grand average of hydropathy-0.280
Instability index55.08
Isoelectric point9.19
Molecular weight168294.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07135
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.50|      33|      33|    1510|    1542|       1
---------------------------------------------------------------------------
  668-  697 (45.22/13.08)	TPSW...PVLQPSQPLPM.MPSQQFPSRPLLPPG.
 1507- 1538 (65.32/22.83)	GWS..GRPYGSPMIPRGG.GGGGGAGRIPLPPWGG
 1539- 1566 (48.96/14.90)	GPSGpPQP..PPG.PGGGvGGSGGWG...LPR.GG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     152.40|      30|      31|     858|     887|       2
---------------------------------------------------------------------------
  698-  733 (26.11/ 8.55)	..VMAT.TPPVGVTS........................dqlsvptpkglE.....DA........FPSPALSS.NN
  734-  772 (27.12/ 9.24)	QSFRSIPVIPGVMTTS......................S...........T.....SLfgqpmkppISYSAASTpSS
  773-  827 (22.88/ 6.36)	VGFKP..QTPASCGGSmlvslldednppqslpppphvgS...........SalppnRI........LSSPVTAT.TP
  828-  871 (31.08/11.93)	IP.SSPITAQVP.NSN......hstpltllpaypkssgS...........S.....DV........LSHLLTST.SN
  872-  904 (45.20/21.52)	IGVSSTNTTPVGVNSS...................ansS...........T.....QS........LPPVLKST.TN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.45|      25|      25|    1403|    1427|       3
---------------------------------------------------------------------------
 1353- 1375 (29.59/13.42)	EEDV.VAVAGVG....ALAS..GT..S..EVEGD
 1376- 1402 (32.07/15.38)	REES.GDMGATL....FGQD..GQSDSqtPPASL
 1403- 1427 (41.56/22.88)	EEES.AAGGGLI....KAPT..DTPDS..PTESI
 1428- 1459 (20.24/ 6.03)	SAKAfVASSKIIpvsqEAPPsgHTPSL..PTGTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     463.94|     144|     158|     911|    1063|       4
---------------------------------------------------------------------------
  911-  965 (44.50/22.50)	......................................................................................................................KKG......RKRR.......VD.............................PSMGGFIST...LPTrAAIMdaikQPAKPTPSKPTALAKESVYDFED....C.P
  966- 1114 (210.77/103.95)	PSTNIALPPPFPPPK........PFAFSDVSAPERTAERKSGLKFV......IKTNRSGTGGGLTAAAGAATTPTENSAVVTKPRT...KAVEGKP..FALFKQMQQQQqpsTSSQhpKKE......RKRRvssknkeVQ.............................PSLVLSISSpkvFPS.APIV.........TP...TPSPKK..HGFVK....G.K
 1115- 1214 (80.97/30.28)	PGRKKTLSTSSEPKRnrlissdePSVESGAVAPS......SGVSGVgssgggNSTNRLIKGYKIPKVRKLPSPPPNNSPPVTSQSTnqeEAVTGRTevTATTTTMS.....................................................................................................................
 1216- 1351 (127.69/55.43)	.....ALPPP.PPPA........QAASSAMSTITTKSQQRS.LLFI......VENLKRAV..............VESS...TAPQ...................MHQQQ...TSSA.....avvelaRSST.......EAsgdatnvaedtvsadsndnlfekfssastPTKGGTPSI...AP..........LPAKRFKVTPTPGA..GVYDLNDvnlnCrP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     369.75|     115|     157|       2|     119|       5
---------------------------------------------------------------------------
    2-  119 (191.73/117.23)	VPNFSLLEHHPEYlVAQR.......QAIENCIETISRI...RALASPDPCQQHVRFATLRNQLYRIALQCdLQLGDTGPILPPGLSSSGGIAWRLSAdCFSVVISAIPADGYSLPPGTTPPE.....DYPVSV
  153-  282 (178.02/97.84)	VKNLILLYDLPGE.IAQRcraylclQALEQDLLMLSTAvgnRKSNAVTPQSLEIPGLSWKNPTSPSEVSC.LAQSINGSAVGQVIQRTGGVFTVLTY.FVSAVQRAIAMSHAPKPPARSDPEagmlgGFCASV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     145.71|      27|      54|     366|     392|       6
---------------------------------------------------------------------------
  334-  363 (24.52/12.54)	.LHPPLL..FDVESISAIEAITKIPmdslkqNE
  366-  392 (46.95/31.35)	PLHHLLLRQHNQEGLSSIDVHMTLP......NK
  395-  419 (36.47/22.56)	HAYHIV..SNNLRGYVVNEIAFTCP......SQ
  422-  446 (37.77/23.65)	PLVQLLRRKAAW..LSFVESFLLHP......RK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     217.23|      54|      54|     505|     558|       8
---------------------------------------------------------------------------
  505-  558 (89.27/47.37)	LPNLVSIRMGDLGVSEAHVLGA.VLPDGFLSDPNQ...DQIKENGSDDKYDPTGILTR
  562-  613 (83.33/43.71)	LPVALTWLLLQLGCPVVRMLTS.TFPSK..SATSN...GNCKTTKPTGQRRPAVCLAR
  617-  664 (44.63/19.84)	.....ALHLSDDASADGLLAGAdRLSEKSLQDAERlflGDGSEGGSGILYDPT.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.98|      13|      15|    1573|    1586|       9
---------------------------------------------------------------------------
 1573- 1586 (23.64/10.87)	GGGGSGvGVGRGGG
 1590- 1602 (30.34/11.34)	GGSGGG.GPFCGGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07135 with Med1 domain of Kingdom Metazoa
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