<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07132

Description Uncharacterized protein
SequenceMGEFKHFDLSQQFFTYVLKCKGVGREYVELLSDIVTKKHEITMKSMNVTSWHYQSPARRALKRNRLGPPDVYPQDAKQEEDNLGADRLKKGYQVAVTSYEHESIVYNAKVPRLDRLDDTMLRSAQLVMQIMNKKLELNANLDKERKRTGNGLKDSISNGSNSVGSGPQSFFQQFSHNVEKAKRSKERNDWFADLSHGKCLGLLARKLPFFRRKEDALEYLCDYKIPVNRALWFLKLISVGGQGNNSSVNKQKKSTSDQLASELASVFTRYVKLMLTQMNDCAKLESNIVYTDRWPHFVYICKHAYEDGMIEKQEFLMDLLDIFNDRFVQPIANCHSDKSLLHSILQHGSGLPSSTNFHYTALFRIFLLFICQYTDQITQNIVLSKRCAFLTCRRLELFRDEAEEREGRSIDCAALFDDMQQCIHQRAIILTLCGMLYAILIDCPASLIWNKYEVSSNRLPAMLHQLCGSPLDHLPCPFESLPLPPGHGTEKLHEFIQLRLAEVRRRSRACENKWSLNFAQKKGFAATVLQCLEIVAVLDAARLDQPNCIEKIYAVIFNGPSKESFEHEHAIRVKMLLQWAVTMEREGTYRAILVAQLLAFRVNHRKTFKFGSLTLQEILSEFLVTEGPDVEGTDKNRFCHEFANLILLFLELQRAGVFSHDFYVKELIRTGEMLEYVPLMQKIKKREDDKQKQSLNTFTSSALPSQPTEATVAFSTPTLAATTPLVTMPPDIPDEHPYLWRKDLSVHERLLIHLPIPQSGEYRSECNQRSLLLYGIGVERDNAKIELRRFARELTKLWQKRIVVEFSFNKPLEIRFKKRATRFRSCTYYDQLVLSGWCCESFVQMVQDFVDGHSYVLPTAEGLDILLDMCEQAQNIAGIMELAEELLPLLVLVEKVLHERRVDCVPSNISAQIGFVLTAYISHNYYYFLYSQNAFNIVQGLYQIIETQLKCPDSCLTGWSRTIAVFVLDAKKQLIETGLCNRKIEAKRELLKRVLPPWKPVLSSTDKNACTGQRYAYNASTFKELLEEPKRFFSFNEYRRLHGIIDGTDDARYSFVVSALLAAARSKNSGNGNEGTGGTIGERSTGDRLVELANICGHVSAQAAQTEKHLDWCGALQALCCSSLQGGTSNFPDLLMEINVEDSTCHYNIATFYMLLAGRSCFSINALVHQLLHTALKSLLNCGIGKPPDADAEAGVCLALLVLTNIVCQNDQPIILSPQYTGERIISNISKADRWILTESHLHDVGDEVCSLLVTICMIADYTMNKLRDRYSDDNKSVDQRAFRREYISELSKGVLTAMCEQEWVTQRIYKRCEDGAMDCFSSHQLRKNCLGQQLLRMALRRRSEREIVKELTICNGNSKKSLIDKLLSISPEGCTSKHAQQGAIAADALLGEMGKCCRDLFTHSHKSDKKLPPAAVGKAFRLKDITAYWLISPLVHVCPRPGNLPASFPAITVQGKFLKEAAAMLDTSSDNSKEKIQQSAWLLSQEPFLNLVLTCLNGEEQQRDGLVGSMLKQLQDLALKAKENPLLPYLRIFSLEREGVLLRISLVGGMFDSVCHPSNCDTWALTLFQLMLYGVVSRERDRYLFDSCFDMLSTLLVWSITDPMNAVPVNPQDTDTKYRFAIYSVIVKKLRKELNEHALIPELRSLMQFLPIPKPQFELITCEPYGTIPTSPQKIGKSQSQGQINQSTIKASRRGLQFAEKVKLSAYDIIQYLNVDFAFLKRSWNWSMLQAVKLDRVPIPVQRYIQRLVHHSHYNEFYYYEFRKVISFCRPPNLDIYLSPPLMDVSETPAALHHVSSSTSTSTTTSTNSANVPVSAGGPTVDINSALGQGAQGRPMGYQPNSTSGCGQPIPDGSASSAAGAGIVFPGQGGPMPVLSDLAVRGQNSSSPRGARGGRRKATGISTRSQGTTRKQRQQRQQTVDQLAVAAAAAAAAAAQQQQQMTAVGPSPQATYPGTWTSAGPQQALGQQFAAPPSAPSAVGPPGVAINNQTAEDSKMKIHSMILQKRQAQAASGVGPAQQGASAGGPQSAMQDVNGNTILILGCATYQMAGGSVQYGGGMLMKMEAGPMPMADHSQQQQQYAQQQQLIQMQQGKSVHFLPLKSIFVDPQANSQYVVHHQQQRGMPYGQQSVQQAVYDSRLQF
Length2142
PositionKinase
OrganismThelazia callipaeda (Oriental eyeworm) (Parasitic nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Thelazioidea> Thelaziidae> Thelazia.
Aromaticity0.08
Grand average of hydropathy-0.275
Instability index46.67
Isoelectric point8.60
Molecular weight240224.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07132
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.91|      43|      51|    1558|    1608|       1
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 1558- 1604 (71.19/64.85)	PSNCDtwalTLFQLMLYGVVSRERDRYLFDSCF..DMLSTLLVWSITDP
 1612- 1656 (67.72/40.95)	PQDTD....TKYRFAIYSVIVKKLRKELNEHALipELRSLMQFLPIPKP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.86|      25|      50|    1818|    1848|       2
---------------------------------------------------------------------------
 1818- 1843 (45.47/40.08)	GGPtVDINSAL...GQ......GAQG...RPMGYQPNS
 1870- 1906 (30.39/10.65)	GGP.MPVLSDLavrGQnsssprGARGgrrKATGISTRS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     287.17|      94|     134|    1017|    1120|       3
---------------------------------------------------------------------------
 1017- 1120 (139.87/128.04)	YNASTFKELLeEPKRFFSFNE..YRRLH.........GIIDGTD.DARYSfVVSALLAAArskNSGNGNEgTGGTIGERSTGDRLVelANICGhvSAQAAQTEKHL.....DWCGALQALC
 1147- 1257 (147.30/99.44)	YNIATFYMLL.AGRSCFSINAlvHQLLHtalksllncGIGKPPDaDAEAG.VCLALLVLT...NIVCQND.QPIILSPQYTGERII..SNISK..ADRWILTESHLhdvgdEVCSLLVTIC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.67|      27|      52|    1961|    1987|       4
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 1937- 1954 (22.37/ 7.94)	...QQQQQMTAVGPS.PQATYP.....
 1961- 1987 (50.36/27.71)	GPQQALGQQFAAPPSAPSAVGPPGVAI
 2016- 2041 (44.94/23.89)	GPAQQ.GASAGGPQSAMQDVNGNTILI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     439.62|     150|    1130|     199|     407|       6
---------------------------------------------------------------------------
  199-  371 (215.29/195.43)	CLGLLARKLPFFRRKEDAL..EY.LCDYKipVNRALwFLKLISVGGQGNNSSVNKQKKSTSDQLASELA....SVFTRY....VKLMLTQMNDCAKLESNIVYtdrW...PhFVYICKHAyedGMIEKQeflMDLLDIfNDRFVQPIA...NCHSDKSllHSILQHGSGLPSSTNFhytalfrIFLLFIC
 1330- 1496 (224.33/136.65)	CLGQQLLRMALRRRSEREIvkELtICNGN..SKKSL.IDKLLSISPEGCTSKHAQQGAIAADALLGEMGkccrDLFTHShksdKKLPPAAVGKAFRLKDITAY...WlisP.LVHVCPRP...GNLPAS...FPAITV.QGKFLKEAAamlDTSSDNS..KEKIQQSAWLLSQEPF.......LNLVLTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.51|      46|     126|     462|     512|       8
---------------------------------------------------------------------------
  462-  512 (77.46/67.61)	MLHQLCGSPLDHLPC.PFESLPLppghgTEKLHEFIQLRLAEVR..RRSRACEN
  593-  641 (69.05/46.28)	LVAQLLAFRVNHRKTfKFGSLTL.....QEILSEFLVTEGPDVEgtDKNRFCHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.26|      37|     429|    1665|    1709|       9
---------------------------------------------------------------------------
 1665- 1709 (53.96/48.08)	PYGTIPTSPQkigkSQSQGQINQStikaSRRGLQFAEK.VKLSAYD
 2100- 2137 (63.30/37.21)	PLKSIFVDPQ....ANSQYVVHHQ....QQRGMPYGQQsVQQAVYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.40|      16|     429|     855|     872|      11
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  855-  872 (25.31/26.16)	YVLPTAEGldILLDMCEQ
 1287- 1302 (29.09/21.40)	YISELSKG..VLTAMCEQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.69|      20|     625|     681|     703|      13
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  681-  703 (28.55/22.65)	QKIKKREDDkqkQSLNTFTSSAL
 1307- 1326 (39.13/22.96)	QRIYKRCED...GAMDCFSSHQL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07132 with Med12 domain of Kingdom Metazoa
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