<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07124

Description Uncharacterized protein
SequenceMSAKTSKVLSWYQSTADKRILRRHKIGPPDVHPQEPRQEEDNLSNERLRKGYQVGAAPYEHESLVFNSRSAKLDRLEEAHTKSAVLLNIASAKAKERAAWFTDLARGKALSQLAKKVPTIKRREDGLEYLCDYKIPSFRALWYLKVTAALTGSPNTTKQKKSVSDLFSAEYKEIFVKAIKDLTNKMWCVNDLSTCPVYKERWLYISNLSKIAFEDGVIERQDFLNELCDIFSEYFVRRIKNEEKLPQLRIYLLFLTQFLRHINNNLILARRLAHMIAMKLRLYKMEYDEQNNTVTKGAEAFTALTQCSAFRPVIHVLIAVLQNIVIDAPAAVVWNKFKVSTTDKLPFILSQLCGSPLDLLPCAVHELPLTPGKDSERFAELLKLRTTEIVRRSQAVQDKWSFNQKEQFAFGKMPLFSSQIWCYLMLHWAVTAEREGSYRAVIVTKIIYNQVVNQRSYMFGPFHMQDIILNYFYTEAPTVGSNYLFMIGKFSSSFAPYKIVVVSTVHSGSTSRSLSLTVIFNKQYYSFVKELIKSGELDYQRPVMEKYKTETKTTDVISSSLISAQFEDLTPDEPPKPASLISFKQEEKDEHIYLSDAMSMNDRILVQMPLRQTEEHRSEANQRAMVLYGMDDARENHKTEMKKQIAKEICKIWQKKSYVQFAEGNEVPVCKQSINSQKIVEILARFRSQTYYDQMMICGWCAESFSDMIRDFVFAHSLQMPTSEGLDIICGMFESAQYIYGIFELCEAVTPLLLSAEKVIRSLAADVIPDSMSGQLGYVFVAYISRHWHYFLHSDLAPNITNQLYALIERMIRAHEYPMTSWGRTIAAFVYHAKCQLKKSQLSDIKLHGSHDDFRHVFNHGSSSCNGANRYNALFFTDVFEKKLRFFSYHEYKKRLPSFGQLYNRYSFVFNSFIAAKNFMRDYDRLSDLATFCGHISAQIPALADEWVAAIKALCCTGSQHAGYGELLNHIDINDCSTHYPIATFVMLLAGKYAFSVPRLIAELLNNVFPVVMKREQSSFVSGRFNGQCGYFFFLCQLKSLGRGEHDCEPGACLTLLILAQISCATDEPFHCEFVTTDVSEHYVGTTPKVKLLSKCADEQILSMIHWCEMDSVLFPMLSNICILMDTLRGRFKDLDFEPSRIIDNTNYRREYLMIMLKAAQSIICEEDWVTLKMFRIVETNKMEAFNHDRLKQNCLGQQLLRLGIRRRSEREVLRELSVCNGNSKKALIDKLLAVMNMWNMRATLFDLMLMIKEISPEGAQKHAQQSAIAADALMGEIGKCCRDLFTNAHKEGIQLPSAVLGRDFRFHHVTNFWLIALLVRLCPQPSNVPNQFHHMTVSGKFLKEAASMLDTANDSSKERIQQSAWLLSQQPFLNLVLACLKGEDFQQNKDMLVSSLYKQLLDLTSKTKENPALPLMEKFSAEREGLLLRLSLVGGIFKQICQPQHSEGWSHLFFSLMLYGMVSPDKDRILYDSCYDMLSTLMLWTLTGPSTTQQISEGSEPKFRWPYYSIIIKKLKKEIADQRVPPELRALLQFLPIPKNTISVFAMEPYGATSTANAQKTSVSGTRPTSAQSTTQSGLRRGRHVLQVSEKVKTSSYDFIHAYISEQNNKGGWKWSWFQVRFRNIVIMIFACSLICRTYGVTASSRCNCFCFASNYRFTILQGSKLDRLPCPVQKWVARLLIHKHQLEYQRPNAVITEASDHFLSAPAVEATGEAPALSSSNANTPGTQTPATPTASGGLEATTPSTEVSSSAVKDPTKTKIQECINKKRLEAARISAGFPGPTSSQPSTIGPGATQGQYSDAGFNQSANNRSVAGDYQQHQSGQNTFQQNTGPHLQTMLQPSSQPMDSSMQSQQQQQQIQIQQQQQQQQQQQQQQQKPAQQQMQQASQLQQNIHNVPSHQQQQVPSGVQHSIQPQVMQQMQHQMPQQMSSQHAMQQQTHLSSQSMQSQPMQHQQLPQQSLLQQQIGHQQQQPRTGNNQSIVTGQQFPQGGGSSQIGGSMQMNFQGQTHSGAAQQSQQPRNPMGQFASRDGGMSMDYQQGSRGGRQQLQMGSQPGVARGMSGGQPHVGSQHVPDGHQMVSQQMVGMPMGAQQMQHQIGQAQMSGQQYYMQQEQRMLNQPYNQYPQNSQF
Length2130
PositionKinase
OrganismNippostrongylus brasiliensis (Rat hookworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Trichostrongyloidea> Heligmonellidae> Nippostrongylinae> Nippostrongylus.
Aromaticity0.09
Grand average of hydropathy-0.385
Instability index51.15
Isoelectric point8.85
Molecular weight241954.04
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07124
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      94.88|      16|      16|    1853|    1868|       1
---------------------------------------------------------------------------
 1845- 1866 (22.85/ 7.70)	SQpmdssmQSQQQQQQIQIQQQ
 1867- 1884 (24.69/ 9.00)	QQ....qqQQQQQQQQKPAQQQ
 1951- 1966 (23.86/ 8.41)	PM......QHQQLPQQSLLQQQ
 2091- 2106 (23.47/ 8.14)	AQ......QMQHQIGQAQMSGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     189.04|      30|      30|    1986|    2015|       2
---------------------------------------------------------------------------
 1896- 1923 (40.29/18.94)	HNVP....S.HQQ.....Q.QVPS...G......VQHSiqpQ.....................VMQQMQ
 1924- 1972 (37.20/16.82)	HQMPQQMSSQHAM.....Q.Q..Q...T......HLSS...QsmqsqpmqhqqlpqqsllqqqIGHQQQ
 1973- 2002 (49.20/25.05)	QPRTGNNQSIVTG.....Q.QFPQ...G......GGSS...Q.....................IGGSMQ
 2003- 2035 (40.51/19.09)	MNFQGQTHSGAAQ.....QsQQPRnpmG......QFAS...R.....................DGG.MS
 2036- 2069 (21.83/ 6.28)	MDYQ.QGSRGGRQqlqmgS.Q.P....GvargmsGGQP...H.....................VG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.83|      53|     278|    1092|    1195|       3
---------------------------------------------------------------------------
  343-  400 (82.56/36.37)	DKLPF.ILSQLCgSPLDLLPCAVHELPLTPGK..DSERF.AELLKLrtteIVRRSQAV..QDKW
 1111- 1169 (75.27/145.25)	DSVLFpMLSNIC.ILMDTLRGRFKDLDFEPSRiiDNTNYrREYLMI....MLKAAQSIicEEDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.84|      20|     276|     134|     153|       4
---------------------------------------------------------------------------
  134-  153 (37.75/19.71)	KIPSFRA.LW.YLK....VTAALTGS
  412-  437 (25.08/10.93)	KMPLFSSqIWcYLMlhwaVTAEREGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.85|      48|      52|    1688|    1738|       6
---------------------------------------------------------------------------
 1688- 1734 (64.91/49.61)	......LEYQRPNaviTEA....SD.HF.LSAPAVEATGEA...PALSSS..NANT......PG..TQTPAT
 1735- 1791 (56.01/34.94)	PTASggLEATTPS...TEV....SS.SA.VKDPTKTKIQECinkKRLEAAriSAGF......PGptSSQPST
 1794- 1842 (41.93/23.92)	PGAT...............qgqySDaGFnQSANNRSVAGDY...QQ.HQS..GQNTfqqntgPH..LQTMLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07124 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAPALSSSNANTPGTQTPATPTASGGLEATTPSTEVSSSAVKDPTKTKIQECINK
2) RLEAARISAGFPGPTSSQPSTIGPGATQGQYSDAGFNQSANNRSVAGDYQQHQSGQNTFQQNTGPHLQTMLQPSSQPMDSSMQSQQQQQQIQIQQQQQQQQQQQQQQQKPAQQQMQQASQLQQNIHNVPSHQQQQVPSGVQHSIQPQVMQQMQHQMPQQMSSQHAMQQQTHLSSQSMQSQPMQHQQLPQQSLLQQQIGHQQQQPRTGNNQSIVTGQQFPQGGGSSQIGGSMQMNFQGQTHSGAAQQSQQPRNPMGQFASRDGGMSMDYQQGSRGGRQQLQMGSQPGVARGMSGGQPHVGSQHVPDGHQMVSQQMVGMPMGAQQMQHQIGQAQMSGQQYYMQQEQRMLNQPYNQYPQNSQF
1715
1771
1769
2130










Molecular Recognition Features






MoRF SequenceStartStop




1) MSAKTSKVLSWYQSTADKRILRRHKI
1
26