<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07123

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMARHVILLASGIIVQSHIDCLEARRQALETCIETISQIRAVVPQDSYHQHVRFATLRNQLHRIAIQCELQLGNTGPIIPPGLSSSGGIAWRLSADCFSVVISAIPADGYSLPPGTTPPEDYPVSVAGVHFEFNQDKPIECSVLVEDLKRRNYNALLKHVKNLIGLYDLPALEQDLAMLATAVSSRIPHAASPMSLELTGISCKIANTPNDVNSLAQSINGSAVGQMVQRTGGAFSVLTYFVSAAQKAIAASRIRRVINEKEHTQPEKGMLGGFCASVGLRATANRIQHSLPVVSLVNLIKDGDGYNVAQFTNADNITRVTIAAEFVLKLHPPLLFDAESISEIESITKIPMGSQTEGQPIPLHHLLLRQHQQESLASLDVHMALPNKSQHAYHVVSSDLRGYVVAEIAFTCPSQLPPLIQLLRHKAAWLSFVESFLLHPKKPTAKDEDLTYKFTVNMPSQTLFLISFQHPICSRRKVQVSIKMGDLGVSEATVCGATLPPDLRFSANDSDDVCDPTEILIRSHNLPVSLTWLILKLGCPVARSLTCLFPVLSGSGSPAVAKLSKAAKPVDRFRANCVARARRALDLSQDASADGVLAGADKLSEESLRDAQRLLLGDGGEGGRGPSTLYDPIAGATPIWPVHQPILSLPPPPPLPHLQQFAPGVGTRPLLPPGVMAITPPAGLAPEQPSLSTPKAIEDVFSSPGATSSSVLSFLYVRLSSVIITVNLDGYVKALETKPTAPSSQAFRNMPLIPGIMTTSQATSLFSQSTMKPPSSCSIAPTPNMGFKPQTPVSLPSSGGSMLVSLLDEDNPPQSLPPPPHVATATLSSNRILSSPATAQVPLSPSPITAQVPSSHPVPVPTTSTYLKSSGSTDVLSHLLMSSNSSAGVTGSSSGSSSAQSLPSSLKPPMPETASVKKGRKKRVDSAMGAFISTLPTRDVIMDAMKQPSKPSPVKTAVLAKESVYDFEDGPSSTSIAPPPPKPFGFAENAGPERTAERKSGLKFVIKTNRGGISGGVTTAESTPVVTKPRSKAVEGKPFALFKQLQQQQPPVSSQHTKKERKRRVSSKVKDIQPPLVLSITSPKLLSSTAVTASTSSPKKHSLAKGKPGRRKALSTNSESKRQRLALEDAATEQGALNSNSAAANSTSRLIKGYKIPKVRKVSSPVSQNSPLLSSQSMAQEEATKNEVPVNTLASTSQLSAPNAPPPSLPLTTSPTTAKPHQRTLLFIVENLKRAAAESGALPQSQQATSTATVEAVYPSADAIGEAGGSAEDALATASKDNLFEKFGGFNSLLLVKRIFHSNATTPTKPSSSSSSQLSSTLKRLKTAPTPGTAAHDPNDAVASNKGPENLTTSAVTAAEDEATQDDDDDDDDAATLSAQDAHSDSQTPPASLDEEAAATLPGGLIKASTDTPDSPTESIGPKSFTSSSKIIPVSQEPPPGGHLPSSSTSSSSSLSSGSPFFSKSAPSTRLTSTGLRGGMTRGGVGPRFNYPRGVWGSRPYGSPMPPRGAVGGGRLPPPPWAAASVPPPQPPPGGGGGGGWGGGTPRGPGAGGGVPLYRGANPGGGRGGGSGGGGGGPFGGIRTNPPKN
Length1588
PositionMiddle
OrganismMesocestoides corti
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Mesocestoididae> Mesocestoides.
Aromaticity0.04
Grand average of hydropathy-0.243
Instability index56.24
Isoelectric point9.26
Molecular weight166033.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07123
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     166.26|      24|      24|    1533|    1556|       1
---------------------------------------------------------------------------
  639-  654 (29.79/ 8.41)	WPVHQPIL.S.LP.PPP......PL
  663-  680 (26.27/ 6.50)	GV.......GTRPlLPPGVMAITPP
 1512- 1527 (25.39/ 6.02)	........GGRLP.PPPWAAASVPP
 1533- 1556 (53.20/21.12)	GGGGGGGWGGGTP.RGPGAGGGVPL
 1563- 1581 (31.62/ 9.40)	GGGRGGGSGGG....GGGPFGGI..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     600.10|     104|     105|    1234|    1337|       2
---------------------------------------------------------------------------
  682-  782 (57.62/14.66)	............GLA.PEQPSLSTP..........KAIED...VFSSP...GAT..SSSVLSFLyvrlssviITV..NLD.......GYVKAL.........ETKPTAP...........SSQAfrnmplipgimtTSQATSlfsqsTMKPpssC.SIAPTP.
  809-  911 (110.83/34.63)	.......DNPPQSLP.PPPHVATATlssnrilsspATAQV...PLSPSPITAQV..PSSHPVPV........PTT..S...TYLKSSG.STDVLSHLLMSSNSSAGVTG...........SSSG............SSSAQS.....LPSS...L.K.PPMPE
  912- 1015 (78.96/22.67)	TAS............vKKGRKKRVD..........SAMGAfisTLPTRDVIMDAmkQPSKPSPV........KTAvlAKESVYDFEDGPSST........SIAPPPPKPfgfaenagperTAER............KSGLKF.....VIKT...N.RGGISGG
 1127- 1194 (58.23/14.89)	...............................................EDAATEQ..GALNSNSA........AAN..STSRLIK...GY.KIPKVRKVSSPVSQNSPLL...........SSQS............MAQEEA.....TKNE...V.PVNTLAS
 1234- 1331 (143.20/46.77)	.......AAAESGAL.PQSQQATST..........ATVEA...VYPSADAIGEA..GGSAEDAL........ATA..SKDNLFEKFGGFNSLLLVKRIFHSNATTPTKP...........SSSS............SSQLSS.....TLKR...L.KTAPTPG
 1332- 1393 (68.79/18.85)	TAAHDPnDAVASNKG.PE.....NL..........TT.SA...V.............TAAEDE.........ATQ..DDDD.....DDDDAATLSAQDAHSDSQTP..P...........AS..........................LD.............
 1394- 1466 (82.46/23.98)	...EEA.AATLPGGL.IKA....ST..........DTPDS.....PT.ESIGPK..SFTSSSKI........IPV..SQE...PPPGGH...............LPSSS...........TSSS............SS.LSS.....GSPF...FsKSAP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.08|      20|     105|     275|     294|       3
---------------------------------------------------------------------------
  275-  294 (34.30/20.56)	ASVGLR.ATANRIQHSLPVVS
  376-  396 (31.78/18.50)	ASLDVHmALPNKSQHAYHVVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.27|      14|      23|    1472|    1485|       6
---------------------------------------------------------------------------
 1472- 1485 (26.63/12.49)	STGLRGG.......MTRGGVG
 1491- 1511 (22.65/ 9.42)	PRGVWGSrpygspmPPRGAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.13|      15|     711|      73|      87|       7
---------------------------------------------------------------------------
   73-   87 (30.72/14.36)	NTG..PIIPPGLSSSGG
  783-  799 (26.40/11.10)	NMGfkPQTPVSLPSSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.80|      19|      96|    1103|    1126|       9
---------------------------------------------------------------------------
 1019- 1037 (32.60/13.85)	AESTPVVTKPRSKAVEGKP
 1093- 1107 (23.30/ 9.35)	..STSS.PKKHSLA.KGKP
 1112- 1126 (17.89/12.53)	ALSTNSESKRQRLAL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.10|      34|    1081|     111|     149|      14
---------------------------------------------------------------------------
  111-  149 (56.34/36.12)	LPPGTTPPEDYPVSVAGvhfefNQDKPIECSVL..VEDLKR
 1198- 1233 (55.75/25.84)	LSAPNAPPPSLPLTTSP.....TTAKPHQRTLLfiVENLKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.39|      15|      29|     570|     584|      15
---------------------------------------------------------------------------
  570-  584 (25.31/17.57)	DRFRANCVARARRAL
  600-  614 (23.08/15.34)	DKLSEESLRDAQRLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07123 with Med1 domain of Kingdom Metazoa
Unable to open file!