Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSYPPHPTHSDNLTAYRQVIENGISSISRFRSNAPPDLYRQHVRFATLRNQLFILAQHYDLQLADTGPLLPPGASSSGGIAWRLAADCFSVVISAIPADGYSLPPGTTPPEDYPVSVAAVHFEFNQDKPIECSVLTEDIRKRIYYSLWKHVKNLIALYNLPGEIAQRCRAYLCLQALEQDLIALTTAVSNHLPHPATPMSLELTGGSSMKVANTSRDVECLAQSINGSAVGQVVPRTGGCFSCLTYYISPARRLQVLEEIHSRPPTGLKEGSESGMLDGYCASVGLRATANRAQHSLPLVSLVNLTKDADGYNVAQFTTADNITRVTLAAEFFLKLNPPLLFDIDSITEVEAITKIPMDSIRKQEPQSLRYILLCQREQEGLASIDPHFILPNRTQHSYHVLSNSLRGYLVGEIAFTCPSQLPPLIQLLRQKASWLLFISISVVVNILYRFLDPELTFHFKVGLPSQKTIIVNLMHPLWDTRMVEVSIDIGDLGVSGARLSGAVIPEYMRRQFDMEPNERMGSEEWFNPTAILSQTHNLPIAMTWLLIRLGCPATRVLTELFPYSGSPTPKKEAKEFNNNKIHRSNLQSKDLIERAISRLHFSNDAAANGVLSGADKISKQILDEARFFFLSGNVLEGIVYDPTANATPNWPAALQPNQQSLPPPPQLPTQQIPQVSRPPLLPPGVMATTPPSVITPDQLSNSSVPTPKQVPEDTFPTSASNNQGYRSIPIIPGVMATPSFSQSAQSMRPPVVSTPTNHTFKPQTPASCGPSMLVSLLDEDSSPQSLPPPPHVGSSAIPPNRIISSPVSAAIHQQNLPSGSPLSNSNHSAHTPPTYLKSSGSSSDVLNHLLTSSSSTSSTTMNQGSSSGATVNPSQSAATKPASITPSDPLVVVPSKKGRKRRMEPPLGATFISALPTRATAMENMKQSSVKAGMISSSKPPPLTTAAPVAKVSVYDFEDCPPASTTSTTSITPPPPLPSQSSQIPPQLPLQPPSQSKPQPFVFNEVTTTPERTTEMKSSLKFVIKTNRACLTGSNPVLEKASSVPKPRTKTVESKPVAYLKQMQQHLPSTSTTQQYPKKERKKRVSSKIKEAVSVPSSQPSLVMSISSPKVFPTNVVPVAQSPQKKHGLMKNKTGRKKTLSTSSAASEPKRHRLMPLEESQQPLEPTGSLGGGNGTNRLIKGYKIPKVRKLSTTSNTNASPSLNNNQEDSNASQTVSQATTASGSSIISPSATGKAPQRSLLYIVENLREKRAVEQSQSQQTMTSGSSATVNTYAAVDGTNSADDTLPLVDSSENLFEKFGNTATPNKPGVGSSSSVSSSTKRLKSTPPPPPSVYDQKDPRITTLEDTSAEHLALVPDVHLATEPEDNAADAILSLDTHSDSQTPPASMDEESVSAGGLIKAPTDTPDSPTESLSSKAFVALSKIIPVTQESTAQPPSQPTAVPTGPFYHKSLPPGRPGSNATRGGGMPRGTGPRFNHLRGSAGWGSRPFNAPMMPRGASGGGPGSGVWGGPPPGGIPPPSGGNWGSHPLPPRASAPPLYRAPPPSSFGSGGGGQSRQPPSKN |
Length | 1564 |
Position | Middle |
Organism | Hymenolepis diminuta (Rat tapeworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Hymenolepididae> Hymenolepis. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.391 |
Instability index | 58.63 |
Isoelectric point | 9.21 |
Molecular weight | 167417.50 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07113 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 101.39| 31| 31| 785| 815| 2 --------------------------------------------------------------------------- 762- 804 (38.08/11.89) KPQTPASCGPSmlvslldedsspQSLPPPP.HVGS.....SAIPPNRII 960- 991 (35.78/10.61) DCPPASTTSTT............SITPPPPlPSQS.....SQIPPQLPL 1532- 1563 (27.53/ 6.04) P.PRASAPPLY............RA.PPPS.SFGSggggqSRQPPSK.. --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 736.60| 124| 187| 632| 755| 3 --------------------------------------------------------------------------- 501- 614 (102.57/34.18) SGAVIPEYMrrqFDMEPNermGSEEWfnP.....TAI..................................LSQT.HN.......L....PiamtwllirlgcPATRVLTE............................LFP......................................Y......SGSPTP.............KKEAKE.....FNNN..KIHRSNLQS.KDLIER.AISRL.HFSND..A......AA..N......................GVLSG 632- 755 (224.75/84.34) SGNVLEGIV...YDPTAN...ATPNW..P.....AAL..................................QPNQ.QS.......L....P............PPPQLPTQ..........QIPQ.V......SRPPL.LPPGV.MATTP.....PS..........VITP.DQL....SN......SSVPTP.............KQVPEDT....FPTS..ASNNQGYRS.IPIIPG.VMATP.SFSQS..A......QSMRP......................PVVST 819- 946 (121.53/41.96) SGSPLSN.....SNHSAH....TP....P.....TYL..................................KSSG.SSsdvlnhlL....T............SSSSTSST..........TMNQgS......SSGAT.VNPSQ.SAATK.....PA..........SITPsDPL............VVVPSK.............KGRKRRM....EPP.......LGATF.ISALPTrATAME.NMKQS..SvkagmiSSSKP......................PPLTT 954- 1088 (56.44/15.23) S.......V...YD.......................fedcppasttsttsitpppplpsqssqippqlplQPPS.QS.......K....P............................................QPF.VFNEV..TTTP.....ERttemksslkfVIKT.NRAcltgSNpvlekaSSVPKPrtktveskpvaylKQM.QQH....LP.S..TSTTQQY..............P...............KKERK......................KRVSS 1091- 1157 (50.76/12.90) ................KE...AV.SV..P.....SS...................................QPSLvMS.......I....S............SPKVFPTN..........VVP..V......AQSPQ.KKHGL.M.............................................KN.............KTGRKKT....LSTSsaASEPKRHRL.MP......................................................... 1158- 1293 (68.66/20.25) ....................................L..................................EESQ.QP.......L....E............PTGSLGGGngtnrlikgyKIPK.V......RK....LSTTS.NTNAS.....PS..........LNNN.QED....SN......AS.QTV.............SQATTASgssiISPS..ATGKAPQRSlLYIVEN.LREKR.AVEQSqsQ......QTMTSgssatvntyaavdgtnsaddtlPLVDS 1294- 1424 (111.92/38.02) SENLFEK.....FGNT.....ATPNK..PgvgssSSV..................................SSST.KR.......LkstpP............PPPSVYDQ..........KDPR.IttledtSAEHLaLVPDVhLATEPednaaDA..........ILSL.DTH....SD......SQTP.P.............ASMDEES......VS..AG...G......LIKA.PTDTPdSPTES..L......SSKAF......................VALS. --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 62.37| 19| 26| 1428| 1451| 4 --------------------------------------------------------------------------- 1428- 1451 (35.01/20.58) PvtqesTAQPPSQPT...AVP..TGP.FYH 1455- 1479 (27.36/ 8.08) P.....PGRPGSNATrggGMPrgTGPrFNH --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 93.08| 25| 31| 64| 89| 5 --------------------------------------------------------------------------- 64- 89 (43.48/23.44) ADtGPLLPPGASSSGGIAWRLAADCF 98- 122 (49.60/23.45) AD.GYSLPPGTTPPEDYPVSVAAVHF --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.48| 18| 26| 140| 157| 6 --------------------------------------------------------------------------- 140- 157 (33.05/27.38) RKRIYYSLWKHVKNLIAL 167- 184 (32.43/26.72) RCRAYLCLQALEQDLIAL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 82.47| 26| 31| 261| 291| 7 --------------------------------------------------------------------------- 261- 290 (37.43/33.06) HSRPPTGLKEGSESGmlDGYcaSVGLRATA 295- 320 (45.04/21.33) HSLPLVSLVNLTKDA..DGY..NVAQFTTA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 49.76| 14| 26| 443| 456| 8 --------------------------------------------------------------------------- 443- 456 (23.24/13.52) VVVNILYRFLDPEL 470- 483 (26.52/16.45) IIVNLMHPLWDTRM --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) APPLYRAPPPS 2) KKHGLM 3) KRHRLMPL 4) RLIKGYKIPKV 5) RSLLYIVE | 1537 1126 1151 1179 1240 | 1547 1131 1158 1189 1247 |
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