<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07109

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMIALELGSCAKIIRCSFIVTNDTNMADGDWPSQRFRDNVINRLEPELARNRQNAPNLPVPGDARQVAFCFHSFVSLRQSKNMFSKSAAAKMSTCVPSLRLLMQLTAIVSFYSCYVILSENYEINEITRSVTKSAAAPSSSAMVHSPSYQASQAPPSSYRASGVPPDPQPTQQEASQARIFLPLNFSFDLLIFNWRSKFSFDEQFQAPPLGQPPPMMQSQQTSPLGLNISGIGQGVQRSPIAQHGSVSHQQPFMMSPPASSMSSTQPSPTHQIFNRIKTEQKVSPDMMQREPMQRSWKQPEMVSNAYGPQMFGSAPGSFMEPMHPSTSHSQSTRMVSTHPVQQQAQQASILEHLINSPQYGSQPAQPQRLYETKLRKLMKYAEPLRAKSRQCRMEGNEDAAMKLDNMSEIVEGKKVVTMDCLDQLEEWIYKKHDLLSQTPLVAAVNAVLLNGDSQGNTSDRMSSQGIMPSCTQWGPTPKQHSPHPAPNHAPSNLISPITINSSISNLPVPNSVPLSPQMHSPQMIPVSPGIQQMHHSLDHSHYQRPSPYPHPMTALRSSPQYQQPVRQLTSRTTSASQNTMGGMNPQMDSSIEVPTVGTQVQDDFYSNVDDFLPTPYESMQPASAPVVGGQLPEEARRELLSLRDRIRFDPNVELASDGHSVIVKCSLMSQSVPPLRLVVPKAYPNGCVSAERAALDLDSFFFDDLQSMIHDRLADPSVTKTVTGYLETWESTVRNYYSTQQNQMSVPTSFDDILQNSFDDIISS
Length764
PositionTail
OrganismEnterobius vermicularis (Human pinworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Enterobius.
Aromaticity0.07
Grand average of hydropathy-0.490
Instability index66.54
Isoelectric point6.40
Molecular weight84782.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07109
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     394.67|      67|      67|     465|     531|       1
---------------------------------------------------------------------------
  167-  229 (64.05/19.90)	...........PQPTQQ....EA........SQARIFLPLNFSfdllifnwrSKF.SFDEQFQAPPLGQ..P.PPMM....QSQQTSP.LGLNIS
  234-  316 (65.15/20.37)	GVQRSpIAQHGSVSHQQpfmmSPpassmsstQPSPTHQIFNRI...kteqkvSPD.MMQ....REPMQRSWK.QPEMvsnaYGPQMFG.SAPG..
  323-  367 (53.41/15.44)	..HPS..TSHSQSTRMV....ST........HPVQQQAQQASI.........LEH.LINS.....PQYGSQPAQPQ...................
  465-  531 (124.96/45.47)	GIMPS.CTQWGPTPKQH....SP........HPAPNHAPSNLI.........SPI.TINSSISNLPVPNSVPLSPQM....HSPQMIP.VSPGIQ
  536-  601 (87.10/29.58)	SLDHS.HYQR.PSPYPH.....P........MTALRSSP.QYQ.........QPVrQLTSRTTSASQNTMGGMNPQM....DSSIEVPtVGTQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.40|      23|      24|      56|      78|       3
---------------------------------------------------------------------------
   51-   76 (36.77/21.54)	RQnapNLPVPGDARQVAFCFHSFVSL
   77-  101 (34.63/19.87)	RQ.skNMFSKSAAAKMSTCVPSLRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.03|      15|      16|     394|     408|       4
---------------------------------------------------------------------------
  394-  408 (26.22/18.69)	EGNEDAAMK.LDNMSE
  411-  426 (20.81/13.35)	EGKKVVTMDcLDQLEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07109 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVLLNGDSQGNTSDRMSSQGIMPSCTQWGPTPKQHSPHPAPNHAPSNLISPITIN
2) NLPVPNSVPLSPQMHSPQMIPVSPGIQQMHHSLDHSHYQRPSPYPHPMTALRSSPQYQQPVRQLTSRTTSASQNTMGGMNPQMDSSIEVPTV
3) QFQAPPLGQPPPMMQSQQTSPLGLNISGIGQGVQRSPIAQHGSVSHQQPFMMSPPASSMSSTQPSPTHQIFNRIKTEQKVSPDMMQREPMQRSWKQPEMVSNAYGPQMFGSAPGSFMEPMHPSTSHSQSTRMVSTHPVQQQAQQASILEHLINSPQ
446
505
203
500
596
358










Molecular Recognition Features






MoRF SequenceStartStop




NANANA