<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07108

Description Uncharacterized protein
SequenceMSSGGNGKSLTVVTWHHQTPQRRHLKRGRLGPPDVYPQEAKQDEDNLGDDRLKKGYQVALTTYEHESIVWNAKVPRLNKLDETMSRGAQVIMQILNRKAELNANLDKERKRGSKEGAFQGFSHTTTQAVKSKERKEWFLDLARGKSLSSLAKRPPFFKKKEGALEYLCDYKVPVVRALWYLKLTAVGQTVASNLAKQKKSFVDQLASEQGALFTKFIRYMLTQISETHNLEQNLVYTERWPYFVCLCKHAYERQEFLMDLCDIFSDRFVVPSDNKPHFFTLFRMFLMFFSQYIDQITQNLILSRRCAFLIAKRLAIFKDEAESLQGGPVVPSELFQGMMQCQNQRPLISVLTGMLHAILIDCPGALVWNSFRVAEGIPPPMLNQLCGSPLDQLPCAIEDLPNSSGYGSEKIQEMVQLRVSEVKRRSHAVENHWSLNKMKKISFRTVVHACLEVLGALDAARIDQPRYIEKIYSIVFGGPPKEKFEYEDAIRIKMLLHWAVTVEREGTHRALVVAYLLNYRKHRKEANFGDQQLQEILLEYLNTEAPQPCDPRFDEEFKNLMLLFYELQKLELFSHDSYVKGLITTGEMSDQTPILALIKSREESTAKQQFFTMPPKNLTSGVNLEEKPGDGMGPSIAEMQKDLPDEHPFMGKELTQHERLLIHLPIPQIKQALLLHGVGEQREVALNDLRKIAKEIIKIWSKRIVIEFSLKPVEIRFKKRATVEQISAAVQKFKIQSYYDQIVLCGWFTEVFIAMVSDFVDGHNSVLPSAEGLDVLLSMLDHCKFISGIMDFAKHLLPLLVELEKKLTEQRVDCIPSNISAQLGFVLVAYISHNFNYFLLCEHAVDIVNGLYRIVEKQLSAKYLTGWGRTIAIFVINTKKFLLRTDLPQKEFEVKHEEPARVAPNRQPSNTTAKYSSHFFKELLESPRRIFSFNDYRSWCATLEKFADARYSFVVSALKCAHQCGDNYDRLVELANICGHISAIGSLSSEWCGALQALCCSSVAGNHGFPELLFDINVEDSKCHTTIATFYMLLAGRSCFSMNLLFHELLHSVFRTLINSDSSKTDADAEAGVCLALLVLANMVCQSEKPIVLSPVYAGENYTEKQLFGLADKYILCGSHLFDMNQTIFDLLFSIASISDCSKNKLREWRDENKSEQGFCREYIAQLSKAVLLAMCEQDWITQRVYKICEEISLDLFNSPNLRKNGLGQQLLRMALRRKCERKVVEELTICNGNSKKSLIDKLFSVLNIWNMRATYFDLKLMIKEAIIFSAEVLNAFFCKISPEGTGKVVQQGAIAADALIGEIGKCCRDLFVNARGEGQKLPENATGKGFRLKYITNFWLISPLICCCPKPVNLPPSFSGLTVQAKFLKEAALMLDTTTDGSPERVQQSVWLLSQEPFINLVLTCLKGEEQQRDGLVTSLLKQLQELALKIKENSFLPYLRKFALEREGILLRCSLVGGMFDSVCHQTCCDAWALLFFQLMLYGAISREKDGYLFESCYDMLSTVLIWSITDPANVSPVNSQDPDTKYRFGNYVSIVKKLKKELNERTLIPELRSLLQFLPISKSTFDLVTSEPYGTVVPSPQKLSKGQFGTVPSKVFRIGLQLGDKVKLSAYDMIQNFNAESAVKRSWTWAMFQAVKLDKSPVPIQRCIQRLIQHTHYTEFSRPAICGGPIGPMKEKALEFLSPPAMDTETSMRLPSSAASTTSVTGGVPATSGPPSTIAPPTSADIQVAASRPIGYQNGTPVAVNQSSNGEPLMFSGSLQTVSELTRNPSSASPRGGRGGRRRTAGPSNRATGTTRKKQQRQALEKAQGLSNQMGQNMASAGNSNSSSFWGSQPAPQNPPMYMNTQQVSMTQPEDSKATIQRFVMKRQAAQASGNASQGFGNMPSGSGGQFNPMMMKMESNVAPMDHQPSYSGQTQQMSMVQEPQRTQFNSQQDIYNQQPQPNPGNMFDNRMMGHQQQQQMQFNQPQFQQQY
Length1975
PositionKinase
OrganismEnterobius vermicularis (Human pinworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Enterobius.
Aromaticity0.09
Grand average of hydropathy-0.271
Instability index41.31
Isoelectric point8.67
Molecular weight222782.11
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07108
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     291.06|      93|     114|    1159|    1272|       1
---------------------------------------------------------------------------
 1159- 1263 (136.56/114.96)	FCREYIAQLSKAVLLAMCEQDWITQRVYKICEeislDLFnsPNLRknGLGQQLLRMALRRKCERKVVEEL.....TICNgNSKKSLIDKLFSVLNIwnmRATYF.DLKLMI
 1278- 1376 (154.50/82.47)	FCKISPEGTGKVVQQGAIAADALIGEIGKCCR....DLF..VNAR..GEGQKLPENATGKGFRLKYITNFwlispLICC.CPKPVNLPPSFSGLTV...QAKFLkEAALML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.32|      26|     116|    1414|    1442|       2
---------------------------------------------------------------------------
 1414- 1442 (38.66/36.15)	RDGLVTSLLKQLQElalKIKENSFLPYLR
 1530- 1555 (42.66/30.82)	RFGNYVSIVKKLKK...ELNERTLIPELR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.61|      18|      19|    1769|    1786|       3
---------------------------------------------------------------------------
 1699- 1717 (26.21/15.39)	SSaASTTSVTGGVPATSGP
 1773- 1790 (31.78/20.62)	SS.ASPRGGRGGRRRTAGP
 1827- 1842 (29.62/18.59)	SN.SS..SFWGSQPAPQNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.34|      72|     118|     133|     210|       4
---------------------------------------------------------------------------
  133-  210 (113.32/82.95)	ERKEWFLDLA...RGKSLSSLAKRPPFFKKKEGALEYLCDYKVPVVRALwylkltAVGQTVASNLAKQKKSFVDQLASEQG
  252-  326 (120.02/74.47)	ERQEFLMDLCdifSDRFVVPSDNKPHFFTLFRMFLMFFSQYIDQITQNL......ILSRRCAFLIAKRLAIFKDEAESLQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.95|      26|     120|    1498|    1523|       5
---------------------------------------------------------------------------
 1498- 1523 (49.35/33.19)	SCYDML......STV...LIWSITDPANV..SPVNSQ
 1612- 1648 (33.60/20.13)	SAYDMIqnfnaeSAVkrsWTWAMFQAVKLdkSPVPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.57|      27|     120|    1800|    1826|       6
---------------------------------------------------------------------------
 1800- 1826 (46.85/22.88)	KKQQRQALEKAQGLSNQMGQNM..ASAGN
 1869- 1893 (28.95/11.60)	...KRQA.AQASGNASQGFGNMpsGSGGQ
 1925- 1949 (44.77/21.57)	QEPQRTQFNSQQDIYNQ..QPQ..PNPGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.12|      12|     120|    1000|    1023|       7
---------------------------------------------------------------------------
 1000- 1013 (19.80/34.07)	CSSVagNHGFPELL
 1039- 1050 (24.32/ 6.14)	CFSM..NLLFHELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.04|      16|     119|     744|     771|       9
---------------------------------------------------------------------------
  744-  759 (30.81/33.07)	LCGWFTEVFIAMVSDF
  777-  792 (30.23/ 9.16)	LSMLDHCKFISGIMDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.34|      16|     119|     525|     548|      13
---------------------------------------------------------------------------
  525-  540 (26.66/32.44)	EANFGDQQLQEILLEY
  550-  565 (28.68/12.19)	DPRFDEEFKNLMLLFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.50|      16|     730|     385|     400|      15
---------------------------------------------------------------------------
  385-  400 (31.67/15.52)	LCGSPLDQLPCAIEDL
 1116- 1131 (31.83/15.63)	LCGSHLFDMNQTIFDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.23|      71|     446|     439|     516|      16
---------------------------------------------------------------------------
  439-  516 (110.47/92.81)	KKISFRT.VVHACLEVLGAlDAARI...DQPRYIEKIYSIVFGG....PPKEKFEYEDaIRikmllHWAVTVEREGTHR.ALVVAYL
  879-  958 (106.75/70.69)	KKFLLRTdLPQKEFEVKHE.EPARVapnRQPSNTTAKYSSHFFKelleSPRRIFSFND.YR.....SWCATLEKFADARySFVVSAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07108 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNGKSLTVVTWHHQTPQRRHLKRGRLGPPDVYPQEAKQDEDNLGDDR
2) KALEFLSPPAMDTETSMRLPSSAASTTSVTGGVPATSGPPSTIAPPTSADIQVAASRPIGYQNGTPVAVNQSSNGEPLMFSGSLQTVSELTRNPSSASPRGGRGGRRRTAGPSNRATGTTRKKQQRQALEKAQGLSNQMGQNMASAGNSNSSSFWGSQPAPQNPPMYMNTQQVSMTQPEDSKATIQRFVMKRQAAQASGNASQGFGNMPSGSGGQFNPMMMKMESNVAPMDHQPSYSGQTQQMSMVQEPQRTQFNSQQDIYNQQPQPNPGNMFDNRMMGHQQQQQMQFNQPQFQQQY
5
1679
51
1975










Molecular Recognition Features






MoRF SequenceStartStop




1) KSLTVVTW
2) RFVMKR
8
1865
15
1870