<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07107

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSRMGTNVEQHLFFLDCSRFTEQFFKTELNGLKWKCVTTPPSHRSWVNIDQDPVLSAYAKCLQAGILCAWRRQPSQMHNTLSQIPLPDYRIDVVKELWVFWYSPDEPELVAQYTSHLACMCGENGRGNWATAGIPYEIRTLYFKALHNLIERFVAFSGYVRIGRYFVRPYDLPSSDRLQCLPSYILGISFNFFVHGENIVCTCVNVQKQPAIFRLSPAHLELRKKQAVILGPWSLRAHLIPKESEEVLSANPVQNRLMNDQELHSCVENEPVSSVITLVAGMPKLNPGIKSEYVNDMASFDSGQQTRSQEFFDEDRSVYSNPDASGSKVEKLWNDWELFFGLCGETKLPENSLHKMRSNSFLEEANKTPKKLPKMVLVDVDGVRMWFPSSLVVVQASDDLTLRNVEGESSNEEQENLNENVKQEIAEGFLPDLAVSVNKAADGPSLPSHVPHSLIRKKRRKRLNSGIQYPPKISKNLMFSSMVNGSRVAQRYLEEACILPLYSRRRENTEVLPPVIGSKNDDDTKWNLTDGLRGNECDADQHLSCPCHLENSLRTPIPSTSSRGSPCNKMFCGDENVVGKNKGVKLPFHQRSPTNSNSPSPPCSPIFGRKYERRSPDWIYDHSSRNSSLSGSKGRSDSFDEVQSFSESSADCNSGSPVYRRLVRTASVAPKSSLYHQSLGVQRESELSEPLLGQLDVEMKCFLPKRLTKKNRTREKRKIRSTDTVNAFDMIFLTTGRKEDWKYREWAERGGSGLDFSNSEYGDNICKEMETVLNANSLACDVSVLKDLTFGGSNVQVRPFGTAYDTDMESHTTYINNCSPSTVAMMDTESMVVTDSVHLSPPASNERVEPAVASSSLTGAVANNLLARVGGPPSVGDYKIYPTPPSVDAVQCIGMNQCPPSLPLYHPLPNQTMQNSTSANEQFHENFMLVKNEVDNDLVCGLQGKFIDLSAEKLPLFGKSVVLKIVLCGKYGSDYLKDELAHPKGPYFDKRCQALFSFVARSKRKHIAATPIYQPYREEHKPEENKFLSFDRTRSHIGSSLTSSLAITGPQPGSHGPICMTSNSSSNSLPGVMHAMVNSPVGGMGPGLPVRPPRPQSLAYSSPSVISQHNPGFLSPPSYGASNLMNSGSQIGGMHTSPMNITPQGLGMMPSQPSAMMGGGVGGHSGMNMMHSGLSTQPQPVQQLSQFVSNATFSNQQSNIYGQQLFYQQQVSTPLEPPPPFSQAMNAQYTGGGSVGSTAPSIYGQSAQMIRSSPFMGSATSPMMLSGPRPIQNSMMIHSSGNTSLTNPLYNPGPPALSQNASLANTVTPPQHPEGNSLALAVLLQDTVLDLHYDSAFDACPLCSCNGNIRTKELGMYITPPEVLRQSSSVQNPIVNRPTSGFYINTNATQNCNCGFSAVRHRYLSMKAGLFPEDAKEATDIVDSQSQPVIPHTIWFDPISKKDIDFIALLCEQTLVHDLSGFLDHVSLLNRQCERAVQNDHGGADCVKKTEYVVSDVDQRELPLVFQAACEVACMEMNCRRPRGNFQNLIWHDWGVQIANEMYEPREAECLAVLHEIGPVLEETLRKARSAQMGGSNNIVEGPLTWRHFDRKSLKTGGGIEDDSFPEPIPNILMASEKDAISASPQALRIWEKMLLEPYDQPKDVLYIAVVPDSIMCVEKSKKYFEDLSRIYEQCRFGRHLPFAKDSLKDGFLRVPTRLPVTNPNDFLKQVERHINNGASLIAKLNVQATVAASVSSNTTPNANGNEQMPPPSLPVSGTTSHTEGSLTGMPGPSGPSPISSINCSVEQSGTTNLGNEIQGQSSVAAPPQIPEQIAEGFAKDESGTLPHVIVLYLVNPFLMGADESPLVARVVTVALMRAFTALLDHIDLRHRPQLQMEIIGLQTILDYNGTTVDILKDECGQLNALDQGRMEKTLNERLSSLDAMKTIAFSVYSQSRILLPDVVGSILPTSMTRFGPASAMNDLLEKLRKNEDPVFYKVPSKPFILAPPPPVILRPNNELMQISTEETVLFVSYCLIGLDFLAAAVTDHQGHLLDNCLINLRVKPDHKRGNLRYKQSTQIRDSLYRLWSYILGTLATGTKNWRLVIGKVGRIGHGEFKFWTQLLSKSYLKQVPSRMKQACRPCHQMPGTAEVPGVLSACLVSLEPEAHLRVFPSSFQHDERFAKNARYRILNTPDDASCTHILVFPTSPELNVIIRLDHQGGAGGNDYDDLSTLLDGEIPEEFSAIIKSEDLNPNTTGQSTSMRITGNTGIPTEYTDVFENQPLAAGYYISTAPASELPEWFWSSCPSAKRRNPVHLKSSLHLNTNNVQQGDDITLSAKGSETCQHQLDSQSTVDVLRYVLETYNALSWLNVDLVTGERRSCLPVHIQALMRLCNTVDRLIN
Length2384
PositionMiddle
OrganismEnterobius vermicularis (Human pinworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Enterobius.
Aromaticity0.07
Grand average of hydropathy-0.366
Instability index54.80
Isoelectric point6.24
Molecular weight263676.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07107
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     432.99|      98|     243|     818|     915|       1
---------------------------------------------------------------------------
  184-  291 (90.09/54.78)	....PSYILgisfnfFVHGENIVCT....CVNVQKQPAIFRLSPAHLELRK.K.....QAV...........ILGPWSLRAHLI.PKESeevlSANPVQNRLMNdqelhSCvenePVSsvIT..LVAGMPklNPGI
  297-  375 (95.15/58.40)	NDMA.SFDS......GQQTRSQEFFDedrSVYSNPDASGSKVEKLWNDWELfF.....GLCGE....TKL......PENSLHKMRSNSF....LEEA......N.....KT....PKK..LP..............
  376-  456 (72.12/41.95)	...............KM...VLVDVD...GVRMWFPSSLVVVQ...ASDDL.TlrnveGESSNeeqeNLNENVKQEIAEG...FLP.........DLAVSVNKA.....AD....GPS..LPshVPHSL.......
  818-  915 (175.63/115.87)	NNCSPSTVA......MMDTESMVVTD...SVHLSPPASNERVEPAVASSSL.T.....GAVAN....NLLARVGGPPSVGDYKIYPTPP....SVDAVQCIGMN.....QC....PPS..LP..LYHPLP..NQTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.03|      25|      69|    2283|    2307|       2
---------------------------------------------------------------------------
 2283- 2307 (49.14/31.67)	WFWSSCPSAKRRN..PVHLKSSLHL.NT
 2351- 2378 (35.90/20.97)	WLNVDLVTGERRSclPVHIQALMRLcNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     389.98|      72|      73|    1154|    1225|       3
---------------------------------------------------------------------------
 1040- 1073 (31.88/ 9.70)	...............GSSLT....SSLAITGPQPGSHGPI.CMTSNSSSNSLPG................................
 1077- 1145 (79.92/36.40)	...AMVNSPVGGMGpGLPVRpprpQSLAYSSPSVISQHNPgFLSPPSYGASNLM...NSGSQIGG...MH..TSPM.NI.TP....
 1155- 1225 (116.78/56.88)	.PSAMMGGGVGGHS.GMNMM....HSGLSTQPQPVQQLSQ.FVSNATFSNQQSN...IYGQQLFY...QQQVSTPL.EP.PPPFSQ
 1230- 1301 (87.15/40.41)	QYTG..GGSVGSTA.PSIYG....QSAQMIRSSP.......FMGSATSPMMLSGprpIQNSMMIHssgNTSLTNPLyNPgPPALSQ
 1763- 1810 (74.25/33.24)	SHTE..GSLTGMPG.P.............SGPSPISSIN...CSVEQSGTTN.....L.GNEIQG...QSSVAAP......P....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.36|      30|     627|    1503|    1579|       4
---------------------------------------------------------------------------
  757-  790 (45.26/ 6.16)	DFSN...SEYGDNICKEMETVLNANSLAcdvsVLKDL
 1527- 1559 (51.09/101.09)	NFQNliwHDWGVQIANEMYEPREAECLA....VLHEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     254.24|      80|     443|    1663|    1746|       6
---------------------------------------------------------------------------
 1663- 1746 (124.77/92.28)	SKKYFEDL.SRIYEQCRFGRHLPFAKDSlkDGFLRV......P.TRLPVTnPNDFlKQVERHINNGASLIAKLNVQATVAASVSSNTTPNAN
 2107- 2194 (129.48/81.54)	SKSYLKQVpSRMKQACRPCHQMPGTAEV..PGVLSAclvslePeAHLRVF.PSSF.QHDERFAKNARYRILNTPDDASCTHILVFPTSPELN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     296.19|      93|     439|     477|     576|       8
---------------------------------------------------------------------------
  477-  576 (155.44/110.09)	KNLMFSSMVNGsrVAQRYLE.EACILPLYSRrrenTEVLPPVI.GSKNDDDTKWNLTDGlRG....NECDADQHLSCPCHLENSLRTPI..PSTSSRGSPCNKMFCGD
  933- 1033 (140.74/83.04)	KNEVDNDLVCG..LQGKFIDlSAEKLPLFGK....SVVLKIVLcGKYGSDYLKDELAHP.KGpyfdKRCQALFSFVARSKRKHIAATPIyqPYREEHKPEENKFLSFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.75|      25|     440|    1883|    1908|       9
---------------------------------------------------------------------------
 1883- 1908 (39.84/33.05)	GLQTI...LDyNGTTVDILKDECGQLNAL
 2322- 2349 (38.91/26.07)	GSETCqhqLD.SQSTVDVLRYVLETYNAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07107 with Med13 domain of Kingdom Metazoa
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