<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07102

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDDEEYMKPMLPTVPEKCGPPVIPLGHLIEFAVQQIFHELTVLSELLPKKLDSDRKISIVQFAHSTRVLFIKLLAVVKWVKSSKKFESCASICYFLDQQSQYFVDTADRLVQLAREELVFARLPTFQVALAVDVLTIGTFPRLPLCIKSRFIPDPPITPREEACVLARLNQVIQYRLSSYATKLSPRISKIVIRNGMVTMTVNGEFEVSLTLLGERPVTKWTLLNIRILVEDYEIGFGTKLVHPLQVNMLHNILQLRMDKSLEPLQEVYNFLHSFAQMLQLDVLFCQATQVFSGDMCHYAVIERYDRNIGILILAYWLKRTHNNRYISQYRIKIFIDKENENDGLRVRHFPVGRRLPCIDDRSGRLSINRLLSETVAVRCRERLLRIRERLGLLKPPVIVSLTGRAAPTLTYPLLGVQSHADEMLVVSINDFSGNVIAIVRALGPRPELRELEQLIDDRVPLQTITDKMDRLRILLMLERYRKAVAPLPVRIVPENVFSTRLSSLPELPPDRICLQFIKEEMYYLIVSFTPNEQTGVNIDMYLLSNVERKLNMVRLHPSQLLTTLPESSFSNARNDEDLEPPAKRRRWLGDRRLLTSAVATLDDRLAFMRICEELDRRNVKYKPLAVEPTVGGLILHITDFSEAVPSGSDDFFSSVINCCLRLDTRTRVIWPFECTLINTPLVADFYEPIMRIDYESTKTKTTVMEIHGSGGVSSPNTSESVSTHMIDRLIVFAHMFDPVKEFAAAYYSHYNKYCNVVAFTYHKLVLAYGSNRNMLMMLSWRTQKAPNNKQYFYLTFGIGPNRRTISTDLIKSETLWNPHVLLSSRLQERFNKRRSLIDLVQYLIDSVAPLSALHSFTRIRLQSLRAFCQMMCYDAALALDLQVTISIVDEYRIRLIYGHVHLEFLLLGNSRIGLRDCSLGSTCAFRLRQFCWNFLSPEMRSTNEEKSPSAFGWAATGSGPGSLPPHQMVRSPASRIVSSPMSHMSLSAPPIDSFGSSLRYSSDCRSKTPILLDHDSLHCMTSIDESGNCPLDQYLFALAYLSKLGPALEGYRREHRGSGAHPVIQFRQLIATAESVRLSVLGAAPPNLKHEPFLVNMNIYLDEETMSLRMKLDFGKFSSDNILMFLDGEDIPAESDIRAAELYFVRFVARLGNEIAVVAFANACRLAAPGAFSAIARIMNVQMLCLRPARHNPSEKNADASKHLIPLIYNTQTNTVARRSSGADDDASNATTVLSNVSEQYSLTNEPALWPAIYSLAHNFAVQR
Length1265
PositionTail
OrganismElaeophora elaphi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Elaeophora.
Aromaticity0.08
Grand average of hydropathy-0.063
Instability index48.18
Isoelectric point8.64
Molecular weight143735.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07102
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      24|     940|     245|     270|       1
---------------------------------------------------------------------------
  245-  270 (39.25/31.71)	LQVNML......HNILQLRMD..KSLEPLqeVYN
 1180- 1211 (34.88/21.31)	MNVQMLclrparHNPSEKNADasKHLIPL..IYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.85|      30|     299|     473|     502|       2
---------------------------------------------------------------------------
  473-  502 (52.11/36.33)	RILLMLERYRKAVAP.......LPVRIVP.ENVFSTRL
  773-  810 (44.73/30.04)	RNMLMMLSWRTQKAPnnkqyfyLTFGIGPnRRTISTDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.28|      38|     452|     504|     568|       3
---------------------------------------------------------------------------
  140-  184 (59.03/28.26)	FPRLP...LCIKsrFIPDP......PITPREEACVlarlnQVIQYRLSSYATKL
  505-  551 (56.25/92.53)	LPELPpdrICLQ..FIKEEmyylivSFTPNEQTGV.....NIDMYLLSNVERKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.78|      57|     580|     272|     350|       4
---------------------------------------------------------------------------
  272-  350 (81.54/139.30)	LHSFAQmLQLDVL..FCQAtqvfsgdMChyavierYDRNigiliLAYWLKRTHNnrYISQYRIKI........FIDKENENDGL...........RVRHF
  854-  931 (84.24/73.02)	LHSFTR.IRLQSLraFCQM.......MC.......YDAA.....LALDLQVTIS..IVDEYRIRLiyghvhleFLLLGNSRIGLrdcslgstcafRLRQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.51|      74|     225|     351|     446|       5
---------------------------------------------------------------------------
  351-  446 (110.66/107.51)	PVGRRLPCIDDRsgrlsinRLLSETVA.VRCRERLLRIRERLG....LLKPPVIvsltgraAPTLTYPLL.......GVQSHADemlvvsinDFSGNVIAIVRALGPR
  581-  666 (116.85/71.73)	PPAKRRRWLGDR.......RLLTSAVAtLDDRLAFMRICEELDrrnvKYKPLAV.......EPTVGGLILhitdfseAVPSGSD........DFFSSVINCCLRLDTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07102 with Med14 domain of Kingdom Metazoa
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