<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07098

Description Mediator of RNA polymerase II transcription subunit 13
SequenceLLKRAASEKKKIYKLKMATNGGSLEDCYTNVFAVTELNGLRWKCLTTPVPSQRTWTSIEQDPVLMAYSKCLQAGILCAWRRQPPSSTTTNNPLLIPDYRIDVVKELWVFWYSQEEPELLSQFTSNENSHGNWSVPGIQYEIRTLFFKAFHNLYERQLNRNGYVRIGRYFTRPYDVPSADRIQCSPGYILGINFNFFVHGENTMCTSVNFQRQPTLFRLSRRHLDNGKRQPIILAPWSLRATLLPDQPKTFDDLIVRRVYTGETGFLFSVAKNGENAVPTMVLVDVDGVRLWYPIIFLYCLLTNEKVINLCIFKDMSKFDPKHTNIIYNFCCNFFSRSNTLSQVIENNSSAAVRIHPEGKSLVLAVLLQDTVLDLHYDTVFDSCPICSCNGNIRAKEFGMYITPPEILRQPLSQQQLVVNKPTSGFYNNGAANTCTCGFSAVRHRYLSMKAGLFAEDAKEATDITESPNQPVIPHAIWFDPMSGSPQFQFERIGSDMSKHGEYIISEVDQRELPLVFQAACEIACMEMNSHPPPRDVRSVLLHDWGIQIANEMREPRESECLAALREIAPILEGALRIARSASQYSNNNIVEGPLTWRLFDRKSLKSCGGMFYEIPILSDYFDLKFKDEDGCPEPVPNIMVASEKDAITASPQILRMWEKFALEPYDQTKDVLYIGVVPDSIVCIERSKKYFEDLSRMYEQCRLGRHIPFAKESLKDGILRVSMRYPSTNPGDCDNFLNQVERHIGDNKSLIARLKIYKQCFENEVARILLNNDCIFNRETYRTLLLENQVKYSFQDMYSEKFGQFFQCPNSVGASCSIIGCIGEPLTPDNLTAGDNSSQVPSSSTSLLNEQVLDGVVPDDEPGTLPHVIVLYVINPFLIGVEDNSLVARVVTVALMRSFSALLYRLNTRRRPQLQLEIIGLQTIFDYTAVTSDFLKDDFGRLNAFDQEKSINERLSSVDALKTTAFSVYTQSRIVLPEVVRDILPKSMTRFGPSAAMGDLLSELDKKEPIFYKQLQFKVPSKAFILAPPQPVMLRPSGDLMQINTDETILFVSYCLVGNDWLAATVTDHQGHLLDNCLINLRVNMRYKQSTQIRDSLYRLWSYILGTLATGTKNWRLVIGRLGRIGHGEFKFWTQLLNKSYLKQVGSRMKHACRSCHMISNILETPGILSACLVSLEPEPYIRIFPSSFQHDERFSKSARYRTLTTPDDSSCTHILVFPTSPEINVYDDFSNLLTTDISIIGDDFSDLIVDGEDLMTNPTGPPPNSATFRISSNTGIPNEYGEMSIENQPLATGYYISTAPASDLPDWFWSSCPFVKRRNPVHLKCSLHLNTPNVQQGDDISSFGAKEACHHQLDSQATADVLRYVLETYNALSWLNIDYVTGERRSCLPIHIQALNRLCNTVNRLIN
Length1408
PositionMiddle
OrganismDracunculus medinensis (Guinea worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Dracunculoidea> Dracunculidae> Dracunculus.
Aromaticity0.10
Grand average of hydropathy-0.228
Instability index49.18
Isoelectric point6.14
Molecular weight159812.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07098
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     355.71|     123|     449|     688|     843|       1
---------------------------------------------------------------------------
  217-  318 (104.63/56.06)	RLSrRHLDNGKRQpiiLAPWSLRATL.LPD.QPKTFDDLI..VRRvYTGET.GFL..FSVAKNG.ENAVpTMVLVDVDGV..RLWYPIIflycLLTNE.kvINlCIFKDM..SKF...........................................
  702-  838 (187.24/195.08)	RLG.RHIPFAKES...LKDGILRVSMrYPStNPGDCDNFLnqVER.HIGDNkSLIarLKIYKQCfENEV.ARILLNNDCIFNRETYRTL....LLENQ...VK.YSFQDMYSEKFGQFF..QCP.....NSVGASCSIigcigePLTPDNLTAGDNSS
 1274- 1342 (63.84/26.21)	............................................................................NTGIPNE..YGEM....SIENQplaTG.YYISTAPASDLPDWFwsSCPfvkrrNPVHLKCSL......HLNTPNVQQGDDIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.60|      15|     183|     664|     679|       2
---------------------------------------------------------------------------
  664-  679 (25.80/20.63)	PYDQT....KDVLYiGVVPD
  841-  859 (22.80/12.65)	PSSSTsllnEQVLD.GVVPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.52|      14|     183|     355|     369|       3
---------------------------------------------------------------------------
  355-  369 (20.57/16.46)	HPEGKSlVLAVLLQD
  530-  543 (27.95/17.79)	HPPPRD.VRSVLLHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.72|      67|     191|     985|    1061|       5
---------------------------------------------------------------------------
  985- 1061 (105.46/80.24)	PKSMTRFGPSAAMGDllSELDKKEPifYKQLQFKVPSK.AFILAPPQPVMLRPSGDLMQINTDETilfvsyCLVGNDW
 1178- 1245 (110.27/62.57)	PEPYIRIFPSSFQHD..ERFSKSAR..YRTLTTPDDSScTHILVFPTSPEINVYDDFSNLLTTDI......SIIGDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.62|      71|     178|     384|     468|       6
---------------------------------------------------------------------------
  384-  468 (109.67/104.67)	PIcsCNGNIRAKEFGMYITPPEILRQPLsqqqlvvnkpTSGFYNNGAANTCTCGF..SAVRHRYLSMK...........AGLFAEDAKEAtdITESPN
  569-  652 (109.95/72.61)	PI..LEGALRIARSASQYSNNNIVEGPL..........TWRLFDRKSLKSCGGMFyeIPILSDYFDLKfkdedgcpepvPNIMVASEKDA..ITASPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.84|      61|    1195|     146|     208|       9
---------------------------------------------------------------------------
  146-  208 (102.31/85.83)	FKAfHNLYERQLNRNGYVRIGRYFTRPYDVPSADRIQCSPGYILGInFNFFVHGENTMCTSVN
 1344- 1404 (106.53/78.55)	FGA.KEACHHQLDSQATADVLRYVLETYNALSWLNIDYVTGERRSC.LPIHIQALNRLCNTVN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07098 with Med13 domain of Kingdom Metazoa
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