<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07088

Description Uncharacterized protein
SequenceMGMKSLNVISWHYQTPERRALKRNRLGPPDVYPQDVKQEEDNLGADRLKKGYQVAVTSYEHESIVYNVKMPRLDRLDDTMLRGAQLVMQIMAKKMELNANLDKERRRAGSVITKDSTGSGGNGVGGGPQIYFQQFSHNAEKAKKSKERNDWFTDLAHGKPLAVLARKPPFFRKKEDALEYLCDYKVPVNRALWFLKLIAVSGQGCNSNVNKQKKSTTDQLASEFASLFTKYIKLMLNQMSDSAKLESNIVYTDRWPHFVYICKHAYEDGMVEKQEFLMDLLDIFNDRFVQPIENRKNDKTLIHPFLHHGSGFASASSTNQSHYVTLLRLFLLFICQYTDQITQNIVLSKRCAFLVCHRLELYRDEAEEREGRSVDCVELFDDMQQCIHQRAIILTLCGMLYAILIDCPAALIWNKYEVSPGRPPTMLHQLCGSPLDHLPCPFESLPLPPGHGTERLQEFIQLRLAEVRRRSRACENKWSLNYAQKKGFAALVLQCLEIVGVLDAARLDQPNCVEKIYAVIFNGPSKESFEHEHAIRVKMLLQWAVTVEREGTHRAILVAQLLAFRINHRKTFKFARLLKINLKITLKIAGIKKPYISCRKKAVNISFDLTHISSLTLQEILLEFLVTEGPDPENTDKNRFSQEFANLMLLFIELQRAGVFSHDLYMKELIRTGEMLEYIPLMQKIRKRKEDKQKQHQQLSNTVAFPSTFVSQPNETTAALLTGAVTTPPPLVTMPSELPDEHPFLFKDLSVHERLLIHLPIPQSAEYRSECNQRSLLLYGIGAERDAVKLELRRLARELAKLWQKRIVVEFSFNKPLEIRFKKRTTREQLQESMAKFRSCTYYDQLVLCGWCCESFIQMVQDFVDGHSCLLPTAEGLDIILEMCELAQNIAGIMELAEELLPLLVLIERVLLERRVDCVPSNLSAQLGYVLTAYISHNYYYFLYSQNAPNIVQGLYRVIESQLKSSDFCLTGWGRTIAVFVLDAKKQLIETGLCSRKIEAKRELLKRVIPPWKPAHNIGDRNPCGGQRYAYNASTFKELLEEPKRIFSFNEYRRLHAVIDGTDDARYSFVVSALLAVVHGIGNVGGNDNTGIGSGSAAVERLTGDRLVELANICGHVSAQAAQVEKYLDWCGALQALCCSSLQGGTSAFPDLLMEINVEDSTCHYNIATFYMLLAGRSCFSINALVHQLLHTALKSLLNCGIGKVLDADAEAGVCLALLVLANIVCQSDQPIILSPQYTGERISSNICKADRWILTEGHLHDIGDEVCALLVTICMIADYTKHKLRDRYSDDKPIDQRVFRREYIAELSKGVLMAMCEQEWVTQRIYRRCEDGALDCFSSHQLRKNCLGQQLLRMALRRRSEREIVRELTICNGNSKKSLIDKLLNVLNIWNTRATYFDFKLMIREISPEGCTSKHAQQGAIAADALLGEIGKCCRDLFTQSHKSDKKLPPAAVGKAFRLKDITAYWLISPLVHACPRPGNLPASFPAITVQGKFLKEAAAMLDTSSDNNKERIQQSTWLLSQEPFLNLVLTCLNGEEQQRDGLVGSMLKQLQELALKAKDNPLLPYLRIFSLEREGVLLRISLVGGMFDSVCHTSICDTWALTLFQLMLYGVISKERDGYLFDSCYDMLSTLLVWSITDPMNAAAMNTQDPDTKFRFPTYSLIVKKLRKELNERALIPELRSLIQFLPIPKPQFELITCEPYGTLPTSPQKLGKSQSQGQIIQTTVKANRHGLQFAEKVKLSAYDIIQYLNIDSTLLKRPWNWSMLQAVKLDRLPVPVQRYIQRLVHHSHYNEFVRPTICGMDRPPNLDIYLSPPMMDVSETPATLHHVSSSAATSTTTSASSTNVPVSSGGAAMDVGTTLGPVVQGRAMSYQSSSTPTCTSIPDGSTPSSTPGAPSTAATAMIFPGQSGPMPALPDLTGRVQGRAMSYQSSSTPTCTSIPDGSTPSSTPGAPSTAATAMIFPGQSGPMPTLPDLTGRGQNNASPRGARGGRRKAAGLSTRSQGTTRKQRQQRQQTVDQLAVAAAAAAAAAQQQQQQMSSAVGCGGGPPQQPTYPSTWATGPQQTGVPQQFASGPSVPPSGTGQAGTAMGTQTTEDSKMKIHSMILQKRQAQAASGATATQQGVTGGPQPSMQDVNAYQISAGPPQYGGNMIMKVETGANSMQMVDHTQQQQQQQQQQQYAQQQQLIQMQQDVQGGSQYVVHQQQRGGIAYGQSVQQATYDSRQQQLQYGQQPQQQQQQYHPTQQY
Length2247
PositionKinase
OrganismBrugia pahangi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.07
Grand average of hydropathy-0.294
Instability index49.26
Isoelectric point8.66
Molecular weight251261.59
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07088
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     427.28|      56|      56|    1867|    1922|       1
---------------------------------------------------------------------------
 1834- 1875 (59.14/30.01)	AATSTTTSASSTNVPVSSGGA......AMDVGTT........LGP.V...................vQGR..AM.S......Y.QS
 1876- 1932 (113.94/65.57)	SSTPTCTSIPDGSTPSSTPGAPSTAATAMIFPGQ........SGP.MPALPDLTGR..........vQGR..AM.S......Y.QS
 1933- 2001 (99.20/56.01)	SSTPTCTSIPDGSTPSSTPGAPSTAATAMIFPGQ........SGP.MPTLPDLTGRgqnnasprgarGGRrkAA.G......L.ST
 2002- 2039 (40.63/18.00)	RSQGTTRKQRQQRQQTVDQLAVAAAAAAAAAQQQ........Q........................................qQM
 2040- 2094 (57.30/28.82)	SSAVGC.....GGGPPQQPTYPSTWATG...PQQtgvpqqfaSGPsVP..PSGTGQ....................agtamgT.QT
 2098- 2141 (57.07/28.67)	SKMKIHSMILQKRQAQAASGA...TATQQGVTG..........GP.QPSMQDV.....................nA......Y.QI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.61|      25|     132|    1031|    1056|       2
---------------------------------------------------------------------------
 1031- 1056 (42.04/26.04)	YNASTFKELLEePKRIFSFNE..YRRLH
 1165- 1191 (42.58/22.35)	YNIATFYMLLA.GRSCFSINAlvHQLLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.23|      35|      63|    2144|    2181|       3
---------------------------------------------------------------------------
 2144- 2181 (61.20/44.45)	G.PPQYGGNMIMKVETGanSmQMVDHTQQQ..............QQQ.QQQQQY
 2182- 2230 (53.59/29.04)	A.QQQQLIQMQQDVQGG..S.QYVVHQQQRggiaygqsvqqatyDSR.QQQLQY
 2231- 2247 (23.44/ 8.41)	GqQPQ.......................QQ..............QQQyHPTQQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.27|      44|     441|    1100|    1164|       4
---------------------------------------------------------------------------
 1103- 1164 (56.54/73.32)	TGDRLVelANICGhvSAQAAQVEKYL.....DWCGALQALCcsSLQGGtsAFpdllmeinveDSTCH
 1239- 1275 (42.78/13.71)	TGERIS..SNICK..ADRWILTEGHLhdigdEVCALLVTIC..........................
 1573- 1594 (28.94/ 9.86)	.........................L.....EREGVLLRI...SLVGG..MF..........DSVCH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.51|      31|     441|    1364|    1396|       5
---------------------------------------------------------------------------
 1364- 1396 (45.39/41.36)	EIVRElTICnGNSKKSLIDKLLN..VLNIWNTRAT
 1794- 1826 (54.13/38.33)	EFVRP.TIC.GMDRPPNLDIYLSppMMDVSETPAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.43|      11|     441|     510|     520|       6
---------------------------------------------------------------------------
  510-  520 (21.48/12.95)	PNCVEKIYAVI
  949-  959 (20.95/12.44)	PNIVQGLYRVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.51|      34|     441|     194|     234|       7
---------------------------------------------------------------------------
  194-  234 (44.58/42.03)	FLKLIAVSGQGcNSNVNKqkksttDQLASEFASLFTKYIKL
  621-  654 (57.93/34.36)	LLEFLVTEGPD.PENTDK......NRFSQEFANLMLLFIEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.03|      60|    1248|     424|     498|       9
---------------------------------------------------------------------------
  433-  497 (96.57/82.68)	SPLDHlPCPFESlPLPPGHGTERLQ.EFIQ.....LRLAEVRRRSRACENKWSLNyaqKKGFAALVLQCLE
 1470- 1535 (97.46/47.24)	SPLVH.ACPRPG.NLPASFPAITVQgKFLKeaaamLDTSSDNNKERIQQSTWLLS...QEPFLNLVLTCLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.12|      15|      28|    1317|    1331|      20
---------------------------------------------------------------------------
 1317- 1331 (30.03/18.41)	C.EQEWVTQRIYRRCE
 1347- 1362 (22.09/11.52)	ClGQQLLRMALRRRSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07088 with Med12 domain of Kingdom Metazoa
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