<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07087

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDDEEYMKPMLPTVPEKCGPPVIPLGHLIEFAVQQIFHELTVLSELLPKKLDSDRKISIVQFAHSTRVLFIKLLAVVKWVKSSKKFESCASICYFLDQQSQYFVDTADRLVQLAREELVFARLPIFQVALAVDVLTVGTFPRLPLCIKSRFIPDPPITSREEACVLARLNQVIQYRLSSYGTKLSPRISKTVIRNGMVTMTVNGEFEVSLTLLGERPATKWTLLNIKILVEDYEIGFGTKLVHPLQVNMLHNVLQLRMDKSLGPLEEVYNLLHSFAQMLQLDVLFCQATQVFSGDMCQYAVIERYDRNMGILTLAYWLKRTHNSYTSQYKIKIFIDKENQHNGLRVRHFPVGKGLPYIDDRSGRLSINRLLSETVGVRCRERLLRIRERLGLLKPPVIVSLTGRAAPTLTYPLLGAQSHADEMLVVSVNDFSGNVIAVVRALGSCTELRELEQLIDDRVPLQTITDKMERLRILLMLERYRKAVAPLPVRIVPENVFCARLSSLPELPPDRICLQFIKEEMYYLIVSFTPNGQIGVNIDMYLLSNVERKLNMVRLHPSQLLTTLPESSFLSGKSDGDLEPPAKRRRWLGDKRLLTSAVATLDDRLAFMRICEELERRNVKYKPLTVEPTVGGLILHITDFSEALPAGSDDFFSSVINCCLRLDTRTRVIWPFECTLINTPLVADFYEPIMHVDYESAKTKTTVLEIHGSGGVSSPNTSESVSTHMIDRLIVFAHMFDPVKEFAAAYYSHYNKYCNVVAFTYHKLVLAYGSNRNMLMMLSWRTQKAPNNKQYFYLTFGIGPSRATTTADLSNSEILWNPHILLASRLQERFNKQRSLIGLVQYLIDSVAPLSALHSFTRIRLQSLRAFCQMMCYDAALALSLQVTLSIVDEYRIRLIYGHVHLEFFLLGNSRIGLRDCSLGSACAFRLRQFCSNFLSPELRSANEEKSPSAFAWTATSSGPGSLPSHQMVRSPASRVVSSPMSHMSLSVPPLDSFGSSLRYSSDCRSKTPILLDHDSLHCMTSIDESGSCALDQYLFALAYLSKLGPALEGYRREHRGSGAHPVIQFRQLIATAESVRLSVLGAAPPNLKHEPFLVNMNIYLDEETMSLKMKLDFGKKFGIFKFLDGEDIPADNDIRTAELYFVRFVARLGNEIAVVAFANACRLAAPGAFSAITRIMSVQMNWTEDTPWRPSIQLVMWSQEGSVPRARISPGIVIDQTNISVLILLCLRPARHNPSEKNADASKHLIPLIYNTQTNTVARRSSGADDDASNATTVLSNISEQYSLTNEPALWPAIYSLAHNFTVQR
Length1306
PositionTail
OrganismBrugia pahangi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.08
Grand average of hydropathy-0.023
Instability index46.27
Isoelectric point8.65
Molecular weight147310.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07087
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.35|      36|     471|     502|     627|       1
---------------------------------------------------------------------------
  454-  489 (61.27/27.16)	LIDDRV...PLQTITDKMERLRILLMLERYRKAVAPLPV
  588-  626 (56.08/111.61)	LGDKRLltsAVATLDDRLAFMRICEELERRNVKYKPLTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     296.68|      91|     583|     210|     318|       2
---------------------------------------------------------------------------
  210-  318 (144.16/128.18)	LTL.LG.ERPATKWTLLNIKILVEDYeIgfgtklvhplqvnMLHNVLQLRMDK.............SLGPLEEvynlLHSFAQMLQLDVL..FCQATQVFSGDMC...........QYAVIERYDRNM..GILTLAYWL
  732-  770 (44.11/17.78)	................................................................................FAHMFDPVKE..FAAAYYSHYNKYC...........N.VVAFTYHK......LVLAYGS
  794-  906 (108.41/66.92)	LTFgIGpSRATTTADLSNSEILWNPH.I.............LLASRLQERFNKqrsliglvqylidSVAPLSA....LHSFTR.IRLQSLraFCQ.......MMCydaalalslqvTLSIVDEYRIRLiyGHVHLEFFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.72|      14|      15|     111|     124|       4
---------------------------------------------------------------------------
  111-  124 (22.89/14.68)	VQLAREELVFARLP
  128-  141 (22.83/14.63)	VALAVDVLTVGTFP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07087 with Med14 domain of Kingdom Metazoa
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