<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07081

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFHKCNSKDEYMRTIAKVINAINCNSKSTAVPSVLQSSQYQSNQSAQHSYRAPGVPPDPQPTHQQHQQNIMPQQNSSSAVSSGGINASGISVSPQQQAQQQAIQASPLGAHHPSVPHQTNTPPYSMMPSPAPPAQPSPTHQLYGQRMTINKSDQQKMMMSNAGNAANTNGTNELTQREAMMHRMWKQQQHQDIPYAPPSSMGPNTYMDPMHASTSYLSSGIPCSQVQQSPNQPPPPHLSSQPQPQQQPSLLENLINSPQFGSQPNQPPSSSRPLNMASQTVVDMPRPNSNLTTAQQSEQRLYMEKLHALKPYCEPLRARAQQCRMDGNESAAQKFETMCNVIEGRSRVSFEYLQQVETWIYKKHDFLHAAMVQSPVVSGASVQSVVAAQQQQAMQQSVAPLQQSQPQPLVDAVNAVLLNGDSQGGCYSDRIQSQPQIGTSSSNSNSNGLGINASNLISVQATSAVSSSVSSTVTVSTNQWQSHNGTNALSASTLVPSSTQQLQLLSPSMSNVVNTSSMNAAISNNAQLPHLAHLSHFNQLNSTMPNSPSAPPSHHPIDHTPTSSYQRHSPYPHPPTPIRSQQQLQHISPRMASSNYAPFSKRRKQPVPPTAISQPPPSVVEPSRGNALPPVDNGSGVEDLYVMDDFLPTPLEAMPNNGLSQFGAQLPEAARRELLALSERFTVDPSIELAPTSTAVIVKCNLNSYPVPPLRLVIPRTYPNGQLSVDRAVLDLDSFFFDDLQNVIHERLARPGLSTISDYLENWESIVRSYYMGQQQQTSVPASFDDIFQTTNFDDILS
Length843
PositionTail
OrganismAnisakis simplex (Herring worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Anisakidae> Anisakis> Anisakis simplex complex.
Aromaticity0.05
Grand average of hydropathy-0.642
Instability index68.65
Isoelectric point6.37
Molecular weight92353.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07081
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     187.32|      32|      32|      86|     117|       1
---------------------------------------------------------------------------
   86-  113 (48.60/14.76)	...................QSNQSAQHSYRAPGVPPDP....QPTHQQHQ.Q
  149-  190 (43.50/12.32)	QASP.....lgahhpsvphQTNTPPYSMMPSPAPPAQP....SPTHQLYG.Q
  223-  250 (33.16/ 7.36)	EAMM..............hRMWKQQQHQ....DIPYAP.....PSSMGPN.T
  251-  293 (31.14/ 6.39)	YMDPmhastsylssgipcsQVQQS.......PNQPPPPhlssQPQPQQ.Q.P
  603-  630 (30.92/ 6.29)	...D...............HTPTSSYQ..RHSPYPHPP....TPIRSQQQlQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.22|      26|      26|     464|     489|       2
---------------------------------------------------------------------------
  117-  135 (27.77/ 9.46)	...PQ...QNSSS....AVSSGGINASG.I
  448-  476 (38.61/15.89)	QSQPQPLVDAVN.avllNGDSQGGCYSDRI
  477-  502 (45.84/20.18)	QSQPQIGTSSSNS....NSNGLGINASNLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.91|      54|      92|     660|     713|       3
---------------------------------------------------------------------------
  660-  713 (99.76/54.89)	PPPS..VVEPSRGNA..LPPV........DNGSGVEDLYV..MDDFLPTPL.....EAMPNNGLSQFGAQLPE
  735-  807 (67.15/34.54)	APTStaVIVKCNLNSypVPPLrlviprtyPNGQLSVDRAVldLDSFFFDDLqnvihERLARPGLSTISDYLEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.22|      20|      25|     503|     527|       4
---------------------------------------------------------------------------
  505-  526 (29.49/19.27)	QATSAVSSsvSSTVTVSTNQWQ
  529-  548 (33.73/15.40)	NGTNALSA..STLVPSSTQQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.45|      16|     177|     191|     206|       5
---------------------------------------------------------------------------
  191-  206 (30.66/18.71)	RMTINKSDQQKM.MMSN
  369-  385 (26.79/15.51)	RMDGNESAAQKFeTMCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.19|      14|      75|     561|     574|       6
---------------------------------------------------------------------------
  561-  574 (22.96/11.28)	SSMNAAISNNAQLP
  583-  596 (25.24/13.28)	NQLNSTMPNSPSAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07081 with Med15 domain of Kingdom Metazoa
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