<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07077

Description Uncharacterized protein
SequenceMSAKTSKVLSWYQSTADKRILRRHKIGPPDVHPQEPRQEEDNLSNERLRKGYQVGTTPFEHESLVFNSRSAKLDRLDEAHTKFAILLNSASAKAKERASWFTDLARGKALSQLAKKIPTIKRREEGLEYLCDYRIPSFRALWYLKVTAALTGSPNTTKQKKSISDLFSAEYKDIFVKAIKEITIRMWDVSDISTCPIYKERWIYISNLSKSAFEDGVIERQDFLNELCDIFSDFFVRRVKNEEKLPQLRIYLLFLTQFLRHINNNLILARRLAHMIAMKLRLYKMEYDEQNSTVTKGAEAFTALAQCSALRPVSTADKLPFILSQLCGSPLDLLPCAVHELPLPPGKDSERFAELLKLRTTEIVRRSQAVQDKWSFNQKEQFVFDCFEYFVIPAKLVNSCLDVIGILDSSDVLEPNVIPAIATRIFNFRSENWAEDVGQSCWLLIMLVEENYIFRLKLILHWAVTAEREGSYRAVIVTKIIHHQVLNQQSFMFGPFHMQDIILNYFYTEAPTVGSKHYHQEFASLVILFIELSRHKLFEHDSFVRELIKSGELDYQRPVMDKYKEENKITDVISSSLISAQVGSFSSVLSLCFFFSGDPTVRCVTSRFKFEDLTPDEPPKPSSLVSFRQEEKDEHVYLNDTMSMNDRILIQMPLRQIEEHRSEANQRALVLYGMNNTRENHMFELKKIAKEICKIWQKKIYVQFLEGNDVPLFKQSINSAKVVEILARFRSQTYYDQLVICGWCAESFSDMIRDFVFGNSLQMPTSEGLDIICGMFESAQYIYGIFEFCEAVSFLEKLQLTKVNEMSQTVTPLLLSTEKVIRSLAADVIPGTMSGQLGYVFVGYICRHWHYFLHSGLAPTITNHMYELIERMIRAHEYPMTSWGRTIAAFVYHSKCQLKKAQLSDIKLHGAHDDFRHVFNHGSSSYNGGSRYNALFFKDVFEKKLRFFSYHEYKKRLPSFGQLYNRYSFVVNSFIAAKNFMRDHDRLSDLATFCGHISAQIAALADEWVSAIKALCCTSISQHTGYGELLTHIDINDCSTHYPLATFVMLLAGKYAFSVPRLIAELLNNAFPVIMKREQSAFIGRYSVSEHYVGIVPRIKLLSSFIPSRIVDSTNYRREYLMILLKAVQSIICEEDWVTMKMFRIVETNRMEAFNHDRLKQNCLGQQLLRLGIRRRCERDVVRELSVCNVNSKKALIDKLLSISPEGAQKHAQQSAIAADALMGEIGKCCRDLFTNAHKEGVQLPSATLGRDFRFCHVTNFWLIALLVRLCPQPSNVPNQFHHMTVSGKFLKEAASMLDTANDSSKERIQQSSWLLSQQPFLNLVLACLKGEVFQPNKDMLVSSLYKQLLDLTSKTKENPALPLMEKFSAEREGLLLRLSLVGGIFKQICQPQHSEGWSHLFFQMMLYGMVSPDKDRILYDSCYDMLSTLMLWTLTAPSTATQQISEGSEPKFRWPYYSIIIKRLKKEIADQRIPPELRALLQFLPIPKNTISVFVTEPYGSFTSVNFQKASGNATRTPSIPSSIPLSGLRHGRYALQVVEKVKTSSYDFIHAYINEQSSKGGWKWSWFQATKTDLVLSVSVNLSKRSPRCVVYFEQFCDIAKLFLVHSIKLEELLPQIGMRQEGFLDAGKLLKIFIQHNGFPVSRKYKQWSSRAGRQDFRTVNKWANEYERDEDVVTNASKLDRLPCPVQRWVAKLLVHKHQLEYHRPNAVGFKKKIRKKVITESSDHFLSAPAVEATGEAPPPPSTQTPATPSTSVGATDAITPGNDETITSRNSAVSTPTTNDLPADEITPEQSRGRTTFFEIVARVFNVL
Length1814
PositionKinase
OrganismAngiostrongylus costaricensis (Nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Metastrongyloidea> Angiostrongylidae> Angiostrongylus.
Aromaticity0.10
Grand average of hydropathy-0.221
Instability index42.81
Isoelectric point8.84
Molecular weight207891.04
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07077
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.75|      43|      87|       2|      48|       1
---------------------------------------------------------------------------
    2-   48 (68.70/52.98)	SAKTSKVLSWYQSTADKRILRRHKIGPPDVHpqepRQEE..DNLSNERL
   91-  135 (68.04/42.06)	SAKAKERASWFTDLARGKALSQLAKKIPTIK....RREEglEYLCDYRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.10|      11|      87|     503|     513|       3
---------------------------------------------------------------------------
  503-  513 (21.35/11.72)	LNYFYTEAPTV
  591-  601 (22.75/12.99)	LCFFFSGDPTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.80|      33|     227|    1487|    1523|       5
---------------------------------------------------------------------------
 1487- 1523 (55.58/47.78)	IPKNTIsvfvTEPYGSFTSVNFQKASGNA.....TRTPSIPS
 1718- 1755 (52.22/34.69)	IRKKVI....TESSDHFLSAPAVEATGEAppppsTQTPATPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.67|      21|      92|    1599|    1624|       9
---------------------------------------------------------------------------
  228-  248 (38.37/17.06)	CDIFSDFFVRRVKNEEKLPQL
 1599- 1619 (38.30/17.01)	CDIAKLFLVHSIKLEELLPQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07077 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RRHKIGPPDVHPQEPRQEEDNLSNERLRKGY
2) SAPAVEATGEAPPPPSTQTPATPSTSVGATDAITPGNDETITSRNSAVSTPTTNDLPADEITPEQSRG
22
1732
52
1799










Molecular Recognition Features






MoRF SequenceStartStop




1) AKTSKVLSWYQSTADKRILRRHKI
3
26