<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07071

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMLDHIKFFNKTRKKSGKYERRAGKHGKSITFLTPDDSAVFYDLKQCLMESPISTCPAELSNHPDAQQKPGTFTTKKRQDETLFKEPELARNRQNAPNLPVPGDARQVEEYVFQKCLSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSFHSPPCSAPSVNGTNTNSTSYRASVPPDPQPTQARAQNQATSSAVPQQQIPLQQPQACVVVGHQQSTFPSSDQQRAPPSYASPPLGQPPPQMQPTGAQSVPQQQEPLPRSWDGQGMHYLTPQQQWSQHPLYNQTQQQQQIPSHQGQHHGQQPPSSGQSTVLEALINQPQYPSAPHQASFLIFVKNPEKLQISRHPHMMMSGPGAPMGPGGHIGGSLDSQPDQQQVYNQKLRMLKPYCENLKLRAQQCRMEGNTEAAQKLETMLGVLEGRRVVSLEYLLNLENWIHKKADFLAATTHPHPSVVQNGHMGMAGQGMVDGINAVLNASSEHHLNSVYGTHGAYVPQTLHQGTYPHMHPQQMWPPQHMQQQGMMVGPPINQSGGGGPMQTYRESPVEHHRPYPSMRPQLRPPPVVQSMQSQPSVDSPRMGASNIAIVGRNTIPLSSGPATSTSTTHVVSSVGGNSSTGSSGSAEQPGIDDLYNMDDFLPTPLEAVGGMQGSGNRPSLPEAARREFSQLSDRFEFDSSAESHHDPHSALVNCKMRGQQVPALRLVIPLSYPAACVTVDRAAIDLDAFFYDDLQNVVHERLARPGLHSITEFLNTWVISGLFRNTVQTTESIMRTDPTLIWYSHPTVLWIPSDIAPLLVSP
Length793
PositionTail
OrganismAngiostrongylus cantonensis (Rat lungworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Metastrongyloidea> Angiostrongylidae> Angiostrongylus.
Aromaticity0.06
Grand average of hydropathy-0.627
Instability index56.42
Isoelectric point7.23
Molecular weight87209.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07071
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.56|      29|      29|     130|     158|       1
---------------------------------------------------------------------------
  130-  157 (45.60/16.84)	...............NAINCNSKS..AAVPSVLQ....PSFHSPPCSAP
  158-  189 (40.18/13.96)	S.............vNGTNTNSTSyrASVPPDPQ....PTQARAQNQAT
  190-  236 (34.78/11.08)	SsavpqqqiplqqpqACVVVGHQQ..STFPSSDQqrapPSYASPPLGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.96|      18|      18|     300|     317|       2
---------------------------------------------------------------------------
  344-  361 (29.08/11.40)	HMMMSGPGAPMGPGGHIG
  516-  533 (25.87/ 9.11)	GMMVGPPINQSGGGGPMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.58|      22|      47|     494|     515|       3
---------------------------------------------------------------------------
  275-  294 (35.97/10.95)	QHPLYNQTQQQQQIP....SHQGQ
  494-  515 (49.21/17.48)	HQGTYPHMHPQQMWPP..QHMQQQ
  542-  565 (40.40/13.13)	HHRPYPSMRPQLRPPPvvQSMQSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.84|      45|     153|     442|     486|       4
---------------------------------------------------------------------------
  442-  486 (83.94/54.72)	TTHPHPSVVQNGHMGMAGQGMVDGINAVLNASS..EHHLNSVYGTHG
  598-  644 (75.90/48.69)	TTHVVSSVGGNSSTGSSGSAEQPGIDDLYNMDDflPTPLEAVGGMQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.34|      10|      52|     193|     202|       5
---------------------------------------------------------------------------
  193-  202 (20.87/10.14)	VPQQQIPLQQ
  248-  257 (21.47/10.67)	VPQQQEPLPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07071 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AELSNHPDAQQKPGTFTTKKRQDETLFKEPELARNRQNAPNLPVPGD
2) AVPSVLQPSFHSPPCSAPSVNGTNTNSTSYRASVPPDPQPTQARAQNQATSSAVPQQQIPLQQPQACVVVGHQQSTFPSSDQQRAPPSYASPPLGQPPPQMQPTGAQSVPQQQEPLPRSWDGQGMHYLTPQQQWSQHPLYNQTQQQQQIPSHQGQHHGQQPPSSGQSTVLEALINQPQ
3) QISRHPHMMMSGPGAPMGPGGHIGGSLDSQPDQQQV
4) TLHQGTYPHMHPQQMWPPQHMQQQGMMVGPPINQSGGGGPMQTYRESPVEHHRPYPSMRPQLRPPPVVQSMQSQPSVDSPRMGASNIAIVGRNTIPLSSGPATSTSTTHVVSSVGGNSSTGSSGSAEQPGIDDLYNMD
57
140
338
492
103
317
373
629










Molecular Recognition Features






MoRF SequenceStartStop




1) KYERRA
2) MLDHIKFF
17
1
22
8