<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07069

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATDDSWKTPHFRQSVVAKIDEAIQVSGMPTTKNSIEMENHVFQKAKSKEEYLGFVARLILHVREMNSKKSATGNAPGISTAGTNNQGMPDPIGALQTLARQGTGNNQMMSMGGPNHQGIISQPPTNTATNLLQSLNQRPAQPLNMPGIQNKMPGMGMMPSQTGGSMNHMGPIQSMQNNPMLTQMNQMGQGNIPPQMNQMVPGQMGQLGAGQMQQNMQSQMQTQLPGQINNQITGPMGNIQTSISQQMNQIGPGQLGPGQMQQQLNHIQRKSSEMINTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPTRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYIEPLRRMIAKMSNEGNVDKLSKMKKLLEILSNPSKRMPLDTLLKCEVVLEKLDFKRGDGSVGPPVTTLKEHQIFSPLLEAVSAHLQSPVINHTLQRTFGPCLDALFGPEIKNLPPPLKKQKIEESSSEIPDVLQGEIARLDQRFKVSLDPAQQSGSRCIQLICWLDDRHLPCVPPISVTVPADYPSTPPRCVMAPHEYEATTFLCAVQKALNIRIAKLPRRFSLSQLLDTWEMSVRQASAPKEMSITASTVLMGL
Length635
PositionTail
OrganismAtta cephalotes (Leafcutter ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.03
Grand average of hydropathy-0.467
Instability index58.90
Isoelectric point9.39
Molecular weight68909.51
Publications
PubMed=21347285

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07069
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     272.43|      50|      50|     212|     261|       2
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  150-  196 (67.45/23.50)	QNKMPGMGMM.PSQTGGSMNHM..GPIQSMQnN.....PMLTQMNQMGQGNIPP.Q.
  212-  261 (92.51/34.73)	QMQQNMQSQM.QTQLPGQINNQITGPMGNIQ.T.....SISQQMNQIGPGQLGPGQM
  267-  306 (53.23/17.13)	HIQRK.SSEMiNTGFPGPRN..VT.PNQFLR.Q.....SPS.......PSAPSPAGL
  310-  362 (59.23/19.82)	SSNQMVASPA.LVPSPSPQHAIMTGPTRSVN.SvgmapSPSSSLN..TPGGVGATPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.91|      17|      23|     444|     460|       4
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  444-  460 (29.57/27.13)	PVTTLKEHQIFSPLLEA
  468-  484 (32.34/30.60)	PVINHTLQRTFGPCLDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.10|      20|      20|     391|     410|       5
---------------------------------------------------------------------------
  391-  410 (31.93/22.45)	MSNEGNVDKLSKMKKLLEIL
  413-  432 (32.17/22.67)	PSKRMPLDTLLKCEVVLEKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.36|      10|      31|     530|     539|       6
---------------------------------------------------------------------------
  530-  539 (19.62/11.25)	PAQQSGS..RCI
  561-  572 (15.74/ 7.52)	PADYPSTppRCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.28|      20|      22|     583|     604|       7
---------------------------------------------------------------------------
  583-  604 (28.83/30.15)	FLCAVQkaLNIRIAKLPRRFSL
  607-  626 (34.46/27.79)	LLDTWE..MSVRQASAPKEMSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.63|      10|      15|     118|     127|       8
---------------------------------------------------------------------------
   97-  106 (16.28/ 6.27)	QTLARQGTGN
  118-  127 (18.35/ 8.03)	QGIISQPPTN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07069 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNSKKSATGNAPGISTAGTNNQGMPDPIGALQTLARQGTGNNQMMSMGGPNHQGIISQPPTNTATNLLQSLNQRPAQPLNMPGIQNKMPGMGMMPSQTGGSMNHMGPIQSMQNNPMLTQMNQMGQGNIPPQMNQMVPGQMGQLGAGQMQQNMQSQMQTQLPGQINNQITGPMGNIQTSISQQMNQIGPGQLGPGQMQQQLNHIQRKSSEMINTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPTRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQ
66
376










Molecular Recognition Features






MoRF SequenceStartStop




NANANA