<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07062

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPVTNNIPQEGNRGGSISLGMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLYVRLLALVKWANSASKVDKSTHIMAFLDKQSLLFVDTADMLARMARDTLVHARLPNFHIPAAVEVLTTGTYGRLPACIRERIVPPDPITPTEKRSTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVTFLIEQEFSVSLTVMGDGPTVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVVQSRLAESTNPLSEVYHILHYFCQSLQLEVLYSQTLRLIRDRLDDHIHVDEYTPGKCLSISYWRELTRKDPRSELGYRLTVQVDQHDPARPLAVVHIPSLGSKESEIAHRAIRSDQLSMECLLVHTIYVRTRNRLSELKQELQTMLKDVECTLAGSPAILSVPILQPCLRAELLLVTVDTHTGMLQCHVPQYDAPLVPELTMALNGDHSRLPTLISELRFWITQRRCEKTLQHLPATSHERLPVLHHPDHPMSKISRHRMFVQLHRHPTVILIVAFKEKESSPCEIECSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDSGNNDQDGGCITEVVETSNNKRRSTGVGGRTDAAGTPQNRRPKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLKLVQLPAPSPSIATSSAWHALLKRLLSVSIRVQGKGMAKTWTVEFVFYGSPLSSSHPKEQGLRRPVYFQYEMGTADTVSRTVDVLLNDWGQIVHLYLIVHDLAEYFKMEKYNLRNMVSIKSYSYSKLVLAYGPNQGATVTIQWSTNDKAFKLVFGRSPTNTVTNAHSIMKEQLEAHLNRYTNLAQIIHILNETLQPLTSISKLPSIPQLCVHARPRVPVQTFTIMPQCVTLVRIAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDENAVYRRRSQSEDDNPPSPVTMDSDGAGGNVSFLGHHRSGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTANISQANQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPASQSMASPAASNWPGSPSVPRPSPARPGQSPSHAALHSPQASDHKTGSHISRVLPQRSWAGAVPTLLTHEALEMLCCPSSHPSALPGPDMSPLERFLGCVYMRRQLQRFIQTEDCLTGINAEPGVVHFKSESLQCRVGLNPTHFQSLHIKVLSLPEYKDQWSVEELQIIEKFFDTRVAAPPYKHNTLSGFGRMLNVRFKVLKDFVQIMKLDLVPSLVQQQQLKWSVQLCLRIPPSAGPIVPPGTEGVHVCRSKILFFLQITRLGISYQGETPSLVLPFVHDVNTNITQLADRRDLTPPPSAIAAASMQLKRFAEYGANQSECSLFPAVRDLLANFTLPSEPPVISQVVPSPAGTQVASAQQIQNTAMQMHSPMAAGQGPPQGPGPYGIQGMQPMGMMGGPPQ
Length1545
PositionTail
OrganismAtta cephalotes (Leafcutter ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.06
Grand average of hydropathy-0.247
Instability index57.93
Isoelectric point8.49
Molecular weight171347.52
Publications
PubMed=21347285

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07062
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     170.30|      27|      54|    1125|    1151|       1
---------------------------------------------------------------------------
 1093- 1112 (31.40/10.91)	VANSPL.....NPMHVP..........SPAG...LMPT...
 1113- 1136 (28.46/ 9.16)	..SSPGPCSnvQ............vgHSPAG..SFMQTG.H
 1137- 1155 (25.62/ 7.47)	IDGSPFPAS..QSMASP..............aaS......N
 1156- 1192 (36.04/13.68)	WPGSPSVPR..PSPARPgqspshaalHSPQA..SDHKTGsH
 1215- 1240 (23.76/ 6.36)	LEMLCCPSS..HPSALP......gpdMSPLE..RFL.....
 1480- 1497 (25.03/ 7.12)	LPSEPPVIS..Q..VVP..........SPAG..T.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.95|      17|      23|     814|     836|       2
---------------------------------------------------------------------------
  814-  832 (27.10/30.40)	KLVLAYGPNQgaTVTIQWS
  839-  855 (30.85/14.49)	KLVFGRSPTN..TVTNAHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     120.27|      23|      23|     997|    1019|       3
---------------------------------------------------------------------------
  990- 1014 (34.74/13.79)	PPSP...vtmDSDGA.G....GNVS.FLGHHRSG
 1015- 1038 (35.17/14.06)	PQSPA....qQREGL.R....FHPP.LTPPSGSN
 1039- 1059 (23.06/ 6.45)	PHTPA............sphtANIS.QANQHQSF
 1060- 1089 (27.31/ 9.13)	GSSPAtsfnlASPPSlP....PNTPnMLPHPSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.04|      86|     476|     388|     479|       4
---------------------------------------------------------------------------
  388-  479 (134.64/99.62)	NRLSELKQELQtMLKDVECTLAGSPAILSVPilQPCLRAElLLVTVDTHTGMLQCHV...PQYDAPLVPELTMAL.......NGDHSRL..PTLISElrFWITQ
  866-  963 (138.40/83.26)	NRYTNLAQIIH.ILNETLQPLTSISKLPSIP..QLCVHAR.PRVPVQTFTIMPQCVTlvrIAYQGMYCLELRLRGgglvslrDGAYSRFdrSNVVDE..FTPTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.06|      16|      23|     203|     218|       5
---------------------------------------------------------------------------
  203-  218 (27.91/16.77)	LIEQEFSVSLTVMGDG
  225-  240 (26.52/15.57)	LLELEILVSDRETGDG
  709-  724 (25.62/14.80)	LLKRLLSVSIRVQGKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      55.74|      12|      78|     170|     181|       8
---------------------------------------------------------------------------
  170-  181 (19.31/10.50)	LQR....LNQVIQHRL
  486-  497 (21.61/12.80)	LQH....LPATSHERL
  500-  515 (14.82/ 6.02)	LHHpdhpMSKISRHRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.93|      32|     267|      51|      95|       9
---------------------------------------------------------------------------
   51-   82 (52.53/43.98)	LPRKTDMERKIEIYNFSARTRQL....YVRLLALVK
  117-  152 (50.40/20.47)	MARDTLVHARLPNFHIPAAVEVLttgtYGRLPACIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.47|      18|      23|     535|     556|      11
---------------------------------------------------------------------------
  537-  556 (30.20/29.97)	SPCE..IEC...SFYLAVvkHSSIE
  558-  580 (23.27/ 8.96)	DPHDdsIETeipKMYLKV..QSLIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.13|      14|      17|     603|     617|      12
---------------------------------------------------------------------------
  603-  617 (19.88/20.21)	GGcITEVVETSNNKR
  623-  636 (26.25/18.94)	GG.RTDAAGTPQNRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.87|      34|      52|    1319|    1355|      14
---------------------------------------------------------------------------
 1319- 1355 (51.44/34.97)	RVaaPPYKHNTLSGFGRMLNV.RFKVLKdFVQIMKLDL
 1374- 1408 (56.43/29.06)	RI..PPSAGPIVPPGTEGVHVcRSKILF.FLQITRLGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.63|      11|      17|    1257|    1271|      18
---------------------------------------------------------------------------
 1257- 1271 (13.89/18.24)	DCLTGINaePgvVHF
 1277- 1287 (23.74/12.70)	QCRVGLN..P..THF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07062 with Med14 domain of Kingdom Metazoa
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