<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07031

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLLYTVNRKVTSKPFINQESNPIFSLYEGQSLCSLSSRNIAAFTTTTELDDNSGKTWGSHVYVCDLNMPWHIHKVLSNKNTITSLEWDLPGDKLVIADFTGNVQLWMFKDHVLNDWVLIGSTCFIGEHILGAAWFHNGKKTGLVTEKKDSIHYSEKFNHLPFAPSVRQFGGRAAEGVLVVSTTGMVGAVMITKDFLNPICSSTESLGSTRHRITAVDLCYGKNGHILVAVSSGNICLPIRCYRVLVRKNDDKCSITSQALPSFFLQDGAPKDNTYTSVTHLKFVVREDADSLVVAVNSETGGIVEVWELREKSQPVHKLFQPKTLEPFKTVVVWQHQSQYRCQSPITAIATTKLSIVTTLPPPSYVVVALADSSVHCLSRDCLKEISLSSLNMAWRTDEPNNKYFKSSISIASIDLSWLGCVLLACDTRGNLYLYKLLPDGGPSMTLTYACTLLEYCLVTGLDWLDILFCLRSSMIEPLCERLDVSFNRQLQSIQQYHYIQFLCIKTSLYRMLISGQSKAADLSSLLMIHSVATAFKSLLRPSDLISHDKGPAESLATVINDAITDVDKVLLHLDPKEFTVEPSTLQSLQQLIQWVADLALNILARLPEQRLQMKSGGYELLKDHKALNTLRELLVIIRIWGLLRPSCLPVFLRSADNLDVLALLFRLLSKLVQPNGDTQAQQIDDGLIASVARVKGDDLENVKFTNIREGKSLNDSISDKSKTKTGIDETNTNIFAESRPNKSKKHKDLPPLVIHRRNSCNNIESTGTVNLKDNISENDEDEYILQSGNDIPKIHRQSMKDYLKLVTVTPNDEADVKSPEGPLSPRELFFIDLIKAAEEAEENEIKSHSKATEGKHFFPNDFSPTEKGVVNDGNNEMKQTDRESVYFIADLKHDCCLLPNQIMIPQLHQGNSITAIATPVLFYQSFPSQLEYGVESEQLLFVPELNPVEGCMHSGQIVDGIRHLYLGKQPLLVKQCTRCGGKAQVQNMTRTAAIRAWDQRWARACRCGGVWRIHKTCP
Length1020
PositionTail
OrganismDufourea novaeangliae (Sweat bee)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Halictidae> Rophitinae> Dufourea.
Aromaticity0.07
Grand average of hydropathy-0.176
Instability index46.41
Isoelectric point6.50
Molecular weight114087.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07031
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.55|      25|      27|     957|     983|       1
---------------------------------------------------------------------------
  958-  983 (41.69/34.08)	QIVDGIRHLYL.GKQPLLVKQCtRCGG
  986- 1011 (43.86/25.33)	QVQNMTRTAAIrAWDQRWARAC.RCGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.70|      28|      28|     804|     831|       2
---------------------------------------------------------------------------
  804-  831 (45.34/28.26)	YLKLVTVTPN.DEADVKSPEGPLSPRELF
  832-  860 (38.36/22.82)	FIDLIKAAEEaEENEIKSHSKATEGKHFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.40|      17|     195|     463|     479|       3
---------------------------------------------------------------------------
  463-  479 (32.96/24.11)	LDWLDILFCLRSSMIEP
  660-  676 (26.44/17.74)	LDVLALLFRLLSKLVQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.67|      27|     197|     214|     246|       4
---------------------------------------------------------------------------
  214-  246 (39.05/42.74)	ITAVDLCYgkNGHILVAVSS.GNICLpircYRVL
  412-  439 (45.62/29.07)	IASIDLSW..LGCVLLACDTrGNLYL....YKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.04|      30|     197|      83|     112|       5
---------------------------------------------------------------------------
   83-  112 (55.24/38.98)	ITSLEWDL..PGDKLVIA...DFTGNVQLWMFKDH
  279-  313 (39.80/25.94)	VTHLKFVVreDADSLVVAvnsETGGIVEVWELREK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.28|      27|     197|     677|     715|       6
---------------------------------------------------------------------------
  687-  714 (40.82/48.06)	DGlIASVARVK.GDDLENVK.FTNIREGKS
  717-  745 (37.46/13.30)	DS.ISDKSKTKtGIDETNTNiFAESRPNKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.51|      33|     197|     362|     399|       7
---------------------------------------------------------------------------
  328-  360 (57.39/42.36)	PFKTVVVWQHQSQYRCQSP..ITAIATTKLSIV..TT
  363-  399 (45.12/57.47)	PPSYVVVALADSSVHCLSRdcLKEISLSSLNMAwrTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.82|      15|      30|     509|     523|       8
---------------------------------------------------------------------------
  509-  523 (26.26/18.25)	SLYRM..LISGQSKAAD
  539-  555 (22.55/14.55)	SLLRPsdLISHDKGPAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.60|      15|      26|     761|     775|       9
---------------------------------------------------------------------------
  761-  775 (26.18/15.55)	SCNNIESTGTVNLKD
  789-  803 (27.43/16.61)	SGNDIPKIHRQSMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.76|      13|      21|     900|     912|      11
---------------------------------------------------------------------------
  900-  912 (25.08/15.65)	LPNQIMIPQLHQG
  923-  935 (24.67/15.27)	LFYQSFPSQLEYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.95|      19|      30|     556|     583|      12
---------------------------------------------------------------------------
  556-  575 (25.10/34.93)	SLATVInDAITDVD.KVLLHL
  589-  608 (26.86/10.17)	SLQQLI.QWVADLAlNILARL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07031 with Med16 domain of Kingdom Metazoa
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