<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07027

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNNQGQSPPPDPNNNNVSLSLVIHRLVENSYNNLLSLTEKLPNHNDQDRKKAIIDYLDSTREKFLRLLVLMKWSDHVSTLTKANQIMHLLNQEDSYFRDTADELIMTKFNLINARAPIYDIPTAIDVLTTGSYQRMPTDIKKVIPPPPLTSIEIDSAMEKLNDIIKYKLFITDIPKEFEPIRVENGIAHIVVPNEYSATLSIDGGTEKSNWVLTSLNLYIYSQKDQNGEGPIKVAYENKMKYVQDRIQNRISSSSSPLFELHNIVHHLCITSQLDILISQIDGLKKTMIKNNIKCVQGKDQSLTVFYWIPEEMNIASAGPTSLGNLNIMKNTNFRISIDETLKLKVTHYPNIHHPKNENYFNLNVNLNLETLLLKTIELNSYHKVLALFNILLSKSNSNPPTSSSTSTGPSISNPSSILLSTQFNAINNRSFHLNDIKLVHSSKFSSDANMNGDISVQEGTLPTVLRIKLYGSKYLDVSVNFQNGRYNLLKSSSSSSSSSYFQSIQEISQQQELKLNSDPNEIRSIVNIFKHRSLLSCFEEASLFLGIESFYKLPITFSNIPTISEILQADSNYIYTRLPQEVDNYYLIINIQPQTFIPTFYLITCRTNTKSSILYAESIIRLENESLQSLLKSCDCNNSQFQFRIQNLLSQIISVAKEKIHFLNITQHLQKQSIPFEIYQSDKIQFVYTPTVPHLTNPSQPPQPINPKHYLLNTDKMLIRILNDIPHSHISNNGCSTKVGSFNYYYEISFQCPRLLNYDNSLMKLDSERLNFHYQDGQWKFRYSSSSSSQDWLTRFNNDLISINCMANITSLILKEIKSQPDQYPPSVIQVVSIQPMEIQLLLFPQKETRNLLHIYIKDPQKKKEVSLLFQPSPNPLVPFLEKELNNDQQPSYHQNISHFLKSIINSNDISFAIHNLLVPPQHRLLQLQSNGATQPPSTSIGSTISNHQTQQPTSLVFNPLDLLVVPRSTQQIRLIYKNHFGIDIKILSQEYCDIEDSYYSTLNNPTNTTTTGGTTQQPGNTTPTNTQTPATGGASAAAAAQKAKEGIKLNMINSFYQLMEQKLNLPALDNPLNNRTSWMVPIANISKILTKIFIYISSLYVFRQATIFICNIFGTHYKIIQNISIIKWENKYFFFNLIIKEPSIELEMMNKEQNGIKALVPVEDLKLLTEFFHRKVNQQSYKSQTIGSLIQMLTLPPLLFVELCKVIASCKTKPPQCRYARDLTTNTSIWNTANKETFHHSEKTTTIYFIVRFINVQNNNFIDIPLKYNYSQRLMNYWNKLEPFPNQLQQSSASAITLTQDPIESQKIQIIDQTATTASSNFQPSITNIDQPQQSLSDINSYILYFIDNLDQNINSLLPFEK
Length1364
PositionTail
OrganismTieghemostelium lacteum
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales> Raperosteliaceae> Tieghemostelium.
Aromaticity0.09
Grand average of hydropathy-0.334
Instability index48.21
Isoelectric point8.11
Molecular weight155898.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07027
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     794.17|     248|     278|     793|    1066|       1
---------------------------------------------------------------------------
   91-  196 (76.17/38.03)	.......................................................................................................................NQEDSYFRDTADELimtKfNLINARapiyDIPTAIDVLTTGSYQ..RMPTDIKKVIPPPPL..........TSI..EI.D...SAMEKLNDIIKYKLFITDIPKEFEPIRV..EN..GIAHIVVPNEY............................................................................................
  793- 1066 (396.61/344.34)	WLtrfnndlISINCMANITSLILKEIKS.....QPD.........QYppSVIQVVSIQPMEIQLLLFpqketrNLLhiyIKDPQKKKEVSLLFQPSPNPLVP.........FLEKELNnDQQPSYHQNISHFL...K.SIINSN....DISFAIHNLLVPPQH..RLLQLQSNGATQPPS..........TSIGSTISN...HQTQQPTSLVFNPLDLLVVPRSTQQIRLIYKNHFGIDIKILSQEYCDIEDSYYSTLNNPTNTTTTGGT.....TQQPGNTTPTN..TQTPATggasaaaAAQKAKEGI........KLNMINS....FYQLMEQKLN
 1080- 1357 (321.39/226.37)	WM.......VPIANISKILTKIFIYISSlyvfrQATificnifgtHY..KIIQNISIIKWENKYFFF......NLI...IKEPSIELEMMNKEQNGIKALVPvedlkllteFFHRKVN...QQSYK................SQ....TIGSLIQMLTLPPLLfvELCKVIASCKTKPPQcryardlttnTSIWNTANKetfHHSEKTTTIYF......IV....RFIN.VQNNNF.IDIP.LKYNYSQRLMNYWNKLEPFPNQLQQSSAsaitlTQDPIESQKIQiiDQTATT.......ASSNFQPSItnidqpqqSLSDINSyilyFIDNLDQNIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     414.65|     128|     140|     463|     602|       2
---------------------------------------------------------------------------
  393-  488 (93.00/53.90)	LSKSNSNPPTSSSTSTGPSISNPSSILLSTQFNAInnRSFhLNDIKlvHSSKFS.................................................................................................sdanmngdisvqegtlPTVLR.....IKLyGSK....YLDVSVNFQNGRYN
  489-  629 (186.35/131.68)	LLKSSSSSSSSSYFQSIQEISQQQELKLNSDPNEI..RSI.VNIFK..HRSLLSCF....EEASLFLGI.ESFYKlpitfSNIPTisEILQADS.NYIYTRLPQEVDNyyliINIQPQTFIPTFY.........................................lITCRT.........NTKssilYAESIIRLENESLQ
  631-  781 (135.30/76.01)	LLKSCDCNNSQFQFR.IQN................................LLSQIisvaKEKIHFLNItQHLQK.....QSIPF..EIYQSDKiQFVYTPTVPHLTN....PSQPPQPINPKHYllntdkmlirilndiphshisnngcstkvgsfnyyyeisfqcPRLLNydnslMKL.DSE....RLN..FHYQDGQWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.85|      33|      86|     215|     247|       3
---------------------------------------------------------------------------
  215-  247 (56.68/34.35)	SLNLYIYSQKD...QN..GEGPIKVAYENKMKYVQDRI
  267-  300 (39.40/21.56)	..HLCITSQLDiliSQ..IDGLKKTMIKNNIKCVQGKD
  302-  336 (48.77/28.50)	SLTVFYWIPEE...MNiaSAGPTSLGNLNIMKNTNFRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.29|      22|     349|      16|      37|       4
---------------------------------------------------------------------------
   16-   37 (35.98/26.40)	NVSLSLVIHRLVE.NSYNNLLSL
  366-  388 (31.31/21.83)	NLNLETLLLKTIElNSYHKVLAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07027 with Med14 domain of Kingdom Amoebozoa
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