<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07027
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MNNQGQSPPPDPNNNNVSLSLVIHRLVENSYNNLLSLTEKLPNHNDQDRKKAIIDYLDSTREKFLRLLVLMKWSDHVSTLTKANQIMHLLNQEDSYFRDTADELIMTKFNLINARAPIYDIPTAIDVLTTGSYQRMPTDIKKVIPPPPLTSIEIDSAMEKLNDIIKYKLFITDIPKEFEPIRVENGIAHIVVPNEYSATLSIDGGTEKSNWVLTSLNLYIYSQKDQNGEGPIKVAYENKMKYVQDRIQNRISSSSSPLFELHNIVHHLCITSQLDILISQIDGLKKTMIKNNIKCVQGKDQSLTVFYWIPEEMNIASAGPTSLGNLNIMKNTNFRISIDETLKLKVTHYPNIHHPKNENYFNLNVNLNLETLLLKTIELNSYHKVLALFNILLSKSNSNPPTSSSTSTGPSISNPSSILLSTQFNAINNRSFHLNDIKLVHSSKFSSDANMNGDISVQEGTLPTVLRIKLYGSKYLDVSVNFQNGRYNLLKSSSSSSSSSYFQSIQEISQQQELKLNSDPNEIRSIVNIFKHRSLLSCFEEASLFLGIESFYKLPITFSNIPTISEILQADSNYIYTRLPQEVDNYYLIINIQPQTFIPTFYLITCRTNTKSSILYAESIIRLENESLQSLLKSCDCNNSQFQFRIQNLLSQIISVAKEKIHFLNITQHLQKQSIPFEIYQSDKIQFVYTPTVPHLTNPSQPPQPINPKHYLLNTDKMLIRILNDIPHSHISNNGCSTKVGSFNYYYEISFQCPRLLNYDNSLMKLDSERLNFHYQDGQWKFRYSSSSSSQDWLTRFNNDLISINCMANITSLILKEIKSQPDQYPPSVIQVVSIQPMEIQLLLFPQKETRNLLHIYIKDPQKKKEVSLLFQPSPNPLVPFLEKELNNDQQPSYHQNISHFLKSIINSNDISFAIHNLLVPPQHRLLQLQSNGATQPPSTSIGSTISNHQTQQPTSLVFNPLDLLVVPRSTQQIRLIYKNHFGIDIKILSQEYCDIEDSYYSTLNNPTNTTTTGGTTQQPGNTTPTNTQTPATGGASAAAAAQKAKEGIKLNMINSFYQLMEQKLNLPALDNPLNNRTSWMVPIANISKILTKIFIYISSLYVFRQATIFICNIFGTHYKIIQNISIIKWENKYFFFNLIIKEPSIELEMMNKEQNGIKALVPVEDLKLLTEFFHRKVNQQSYKSQTIGSLIQMLTLPPLLFVELCKVIASCKTKPPQCRYARDLTTNTSIWNTANKETFHHSEKTTTIYFIVRFINVQNNNFIDIPLKYNYSQRLMNYWNKLEPFPNQLQQSSASAITLTQDPIESQKIQIIDQTATTASSNFQPSITNIDQPQQSLSDINSYILYFIDNLDQNINSLLPFEK |
Length | 1364 |
Position | Tail |
Organism | Tieghemostelium lacteum |
Kingdom | Amoebozoa |
Lineage | Eukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales>
Raperosteliaceae> Tieghemostelium.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.334 |
Instability index | 48.21 |
Isoelectric point | 8.11 |
Molecular weight | 155898.89 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
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GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07027
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 794.17| 248| 278| 793| 1066| 1
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91- 196 (76.17/38.03) .......................................................................................................................NQEDSYFRDTADELimtKfNLINARapiyDIPTAIDVLTTGSYQ..RMPTDIKKVIPPPPL..........TSI..EI.D...SAMEKLNDIIKYKLFITDIPKEFEPIRV..EN..GIAHIVVPNEY............................................................................................
793- 1066 (396.61/344.34) WLtrfnndlISINCMANITSLILKEIKS.....QPD.........QYppSVIQVVSIQPMEIQLLLFpqketrNLLhiyIKDPQKKKEVSLLFQPSPNPLVP.........FLEKELNnDQQPSYHQNISHFL...K.SIINSN....DISFAIHNLLVPPQH..RLLQLQSNGATQPPS..........TSIGSTISN...HQTQQPTSLVFNPLDLLVVPRSTQQIRLIYKNHFGIDIKILSQEYCDIEDSYYSTLNNPTNTTTTGGT.....TQQPGNTTPTN..TQTPATggasaaaAAQKAKEGI........KLNMINS....FYQLMEQKLN
1080- 1357 (321.39/226.37) WM.......VPIANISKILTKIFIYISSlyvfrQATificnifgtHY..KIIQNISIIKWENKYFFF......NLI...IKEPSIELEMMNKEQNGIKALVPvedlkllteFFHRKVN...QQSYK................SQ....TIGSLIQMLTLPPLLfvELCKVIASCKTKPPQcryardlttnTSIWNTANKetfHHSEKTTTIYF......IV....RFIN.VQNNNF.IDIP.LKYNYSQRLMNYWNKLEPFPNQLQQSSAsaitlTQDPIESQKIQiiDQTATT.......ASSNFQPSItnidqpqqSLSDINSyilyFIDNLDQNIN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 414.65| 128| 140| 463| 602| 2
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393- 488 (93.00/53.90) LSKSNSNPPTSSSTSTGPSISNPSSILLSTQFNAInnRSFhLNDIKlvHSSKFS.................................................................................................sdanmngdisvqegtlPTVLR.....IKLyGSK....YLDVSVNFQNGRYN
489- 629 (186.35/131.68) LLKSSSSSSSSSYFQSIQEISQQQELKLNSDPNEI..RSI.VNIFK..HRSLLSCF....EEASLFLGI.ESFYKlpitfSNIPTisEILQADS.NYIYTRLPQEVDNyyliINIQPQTFIPTFY.........................................lITCRT.........NTKssilYAESIIRLENESLQ
631- 781 (135.30/76.01) LLKSCDCNNSQFQFR.IQN................................LLSQIisvaKEKIHFLNItQHLQK.....QSIPF..EIYQSDKiQFVYTPTVPHLTN....PSQPPQPINPKHYllntdkmlirilndiphshisnngcstkvgsfnyyyeisfqcPRLLNydnslMKL.DSE....RLN..FHYQDGQWK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 144.85| 33| 86| 215| 247| 3
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215- 247 (56.68/34.35) SLNLYIYSQKD...QN..GEGPIKVAYENKMKYVQDRI
267- 300 (39.40/21.56) ..HLCITSQLDiliSQ..IDGLKKTMIKNNIKCVQGKD
302- 336 (48.77/28.50) SLTVFYWIPEE...MNiaSAGPTSLGNLNIMKNTNFRI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.29| 22| 349| 16| 37| 4
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16- 37 (35.98/26.40) NVSLSLVIHRLVE.NSYNNLLSL
366- 388 (31.31/21.83) NLNLETLLLKTIElNSYHKVLAL
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