<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07024
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MIPLQHKKKSLKEILISNLTDFNRTSHLLFESFHSLAIPNQQQQQKQQQNQQKIDQPQQNVNPLQFMNLLIESDKNLQNSLKQLEKHQKYQNEIVSVQKEIEEKDKLIATLASNLKSIESFLENAILQDTSEGNANTTSATNGILVTKKEQIEQQKSLGTERNEVTPNELISYAHKISGTTSAPFGYQPNTPLMTLYKPPAPQDDMMRASTLFRKLPVNILKYYGLEESDITTPINTMSPVLQAQQLEQQSQIDQQQQMDVDEQQQLQQQQQQIITPPLNQPMMNQPFASLDLDLNSDLESSDQDDDDDEEDKSSDEEVDWE |
Length | 322 |
Position | Middle |
Organism | Tieghemostelium lacteum |
Kingdom | Amoebozoa |
Lineage | Eukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales>
Raperosteliaceae> Tieghemostelium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.895 |
Instability index | 61.23 |
Isoelectric point | 4.53 |
Molecular weight | 36894.57 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07024
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 110.88| 30| 38| 28| 61| 1
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28- 51 (38.22/15.17) ...............LLFESFHSLAIPNQQQQQKQQQNQ
54- 91 (41.18/22.06) IDQPQQnvnplqfmnLLIESDKNLQ.NSLKQLEKHQKYQ
253- 272 (31.49/ 9.06) IDQQQQ.................MDVDEQQQLQQQQQ..
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.32| 14| 16| 139| 152| 4
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139- 152 (22.21/14.68) S.ATNGILVTKKEQI
157- 171 (17.11/ 9.70) SlGTERNEVTPNELI
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