<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07021

Description XK-related protein
SequenceMHNINRERSNVTWVALALQAAWRSGMLISRFIVLILALIFLKAWFFLFLGLHWLFMTIWVILQKTKFCSTAWEERIYNCVIGLIYCFDFFNLRDDRSRYRVLIFYSVIVAQNVVFLIIYMLDVGETIANITMIMIASVIVGCMLIGLTSMSLYYGKFHPSRTATNISRNISEHSTTTKVDASRSFKLFHRDSLVSLHHSMDISPRTEEVPTDKQSLLTNIAQISDCVEEGIVNRNYCSENESNASALRLSTECERPHSRVGVKHKEEVTSVNDNPDNTLTSSPLNSLYSGLPDIDSSRKRRGIYEHDITPQLDWHAPDILNIDLDQLGSLDNSERSNSLTLDSCSKVIGALDVIKNREKLTTPTPLESSRIFDIEKQRDETMSCVTSIHDYENVCPLGIARPPWCIRSWKGYTDIETYIHDDSVVRDRRRDTLTSTTGTTYSSEYSDGMISRGILKQDDYADALTYDLVESKGNKSSYSDSTFSTSADDQNASLYIAKPVVFDDRGGMLALDTILEERDDLSSSDEKFQHGTELSRDSASTLVSTIDQIRRYTADNSPRHIYHTTGTQWEDLNPKNLMAQARFAKVLFDNDLRNASTTTGSIDLTARDVEKREIDAIREFVRCCAIESIKKTPLIDAVLSDSPILDKASKLMRQVTFVDCKNDFDTNESDLYVEMSPLVSVENGENLCQARPIDAKTAEAESDTLKRNTLPTISKKSPNKENLSPSLSNNNRRINNIYDDRDNNDSHAWTIERDEKNDKSLCNMRFNLKEKRHLFLEQVLSPVPKLWNKLGQPSPGGGSASDKGKEWQMEFLMEKLRSKSSTYKSLVETAKNMRMAMLDKRFAIDSIEKNQLQKCLDTLQHSIKVTSFQSMVERLESLARQLGLKFMMSGPPGTEIFISSDMFFLEVLLEPPSGLVRDVKIHHEGKSEQQSCEALASALSRGDFVDFTTQLEGLASIYQLNADKKVKCKAFSALQSLEADLGVLAQLQTFMKEPFNLVHKSPVGILERRRGGHPMKLTYFVSPYDLIDEENRTYDTLNPDTIIKRKIGHSVTVCMEGSTGHKLPTSSIITVNRSPTGKSTPSYASLTSTNSSMLPACFVLKLVKKMPICMELMKKIQKVTELECGDISAPHPLLSLIIQHASDGQLDCRNNRGLYVTLPDQQHCYFMTENKNMEGVLVCSIPFTHPAHVPQILVYLRQQALFNCLIASCVRPMARQDPEHTTILEVSALSWQHISVSVEHPYEETMATVELDLTDISTLKCRLYGVSMTTNVEQTSDLSGRVLQRCLSIPLTMRMLLKIWEGRSLPAVMNSLTSGSGSSNGSYNLNLGSGANNTSASMLNPLQLGALLGQAKNSLTSNSNTNERGKKARKRKTGTDGLWRSPKRKSDGGDSSAATEILLESSSSENSTPLGTPTNRENLASETRTSTPTSATSLTSGMDFTNLDTTDILDKSTSDYDLDNSEKDSEIMEVQHSSAEQQQQQQQQPQQEVEELIKIRESSSTRKSKKNRSGGGSEEKKSSPTNIFVDETSTTSSGNKGLPVPPSVSITPISCGNLDQASTTNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPAPSPKTSGLTSATEDRQRSERKSGGGKSSSSSSKSSSEDTKSSGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGSAGVGLSCSSSRPTSPAAVRKFSPSPTHSSSLATLVGKSSPTLKASQSAAATCGKPVQSPKHSPVYGSTVSVPVPVPAGASPKHGSTSSPKHGSSAASSGKPSMSALKSAAPTQQRLHPKSSLLRRPRVRIPPVVEIKTDERHPSAHLAVQVVAIRVPRPSPPAVK
Length1866
PositionMiddle
OrganismTrachymyrmex zeteki
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.05
Grand average of hydropathy-0.459
Instability index55.14
Isoelectric point8.00
Molecular weight205763.30
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-UniRule
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07021
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     302.01|      48|      74|    1592|    1639|       2
---------------------------------------------------------------------------
 1383- 1464 (24.14/ 6.89)	....KRKSD..G...........................GDSS.AATeillESSS.............senstPLG.TPTNR...E.NLASE...TRTS.....TPTSATsltsgmdftnldttdildkstsdydldnseKD
 1502- 1568 (50.26/24.32)	RKSKKNRSG..G...........................GSEE.KKS....SPTNifvdetsttssgnkglpvPPSVSITPI...ScGNLDQ...ASTT.....NYNSVL..............................TG
 1569- 1618 (65.27/34.34)	.MGLERRPG..I...........................EIIP.IAS....SPSQ...............tnlPSSITITPI...A.GPAPS...PKTS.....GLTSAT..............................ED
 1619- 1652 (44.54/20.51)	RQRSERKSG..G...........................GKSS.SSS....SKSS.....................................sedTKSS.....G..SKL..............................EK
 1653- 1694 (31.08/11.52)	RRKRKREDGpmG...........................PPDKvPSG....GKQQ............qdplskPVSVSIKP...........................ST..............................EQ
 1695- 1744 (57.86/29.39)	SPPSGGSAG..V...........................GLSC.SSS....RPTS..................PAAVRKF.......SPSPT...HSSSlatlvGKSSPT..............................LK
 1745- 1813 (28.86/10.03)	ASQSAAATC..GkpvqspkhspvygstvsvpvpvpagasPKHG.STS....SPKH...........................gssA.ASSGK...PSMS.....ALKSAA..............................PT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.20|      30|      74|     849|     879|       3
---------------------------------------------------------------------------
  849-  879 (45.81/34.49)	KNQLQKClDTLQHSIKVTSFQSMVERLESLA
  926-  955 (49.40/32.58)	KSEQQSC.EALASALSRGDFVDFTTQLEGLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.96|      33|     237|    1060|    1094|       4
---------------------------------------------------------------------------
 1060- 1094 (52.57/30.29)	GHKLPtsSIITVNRSPTGKSTPSY.....ASLTSTNSSML
 1302- 1339 (48.38/22.97)	GRSLP..AVMNSLTSGSGSSNGSYnlnlgSGANNTSASML
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.21|      17|      74|     418|     437|       6
---------------------------------------------------------------------------
  370-  386 (29.16/17.27)	RIFD...IEKQRDETMSCVT
  418-  437 (24.05/21.96)	YIHDdsvVRDRRRDTLTSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.89|      14|      15|    1825|    1838|      10
---------------------------------------------------------------------------
 1825- 1838 (25.47/13.42)	RRPRVRIP.PVVEIK
 1842- 1856 (18.42/ 7.63)	RHPSAHLAvQVVAIR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.33|      19|      43|     464|     483|      11
---------------------------------------------------------------------------
  464-  483 (28.09/23.52)	LTYD.LVESKGNKSSySDSTF
  509-  528 (26.24/15.30)	LALDtILEERDDLSS.SDEKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.73|      12|      69|      29|      47|      14
---------------------------------------------------------------------------
   11-   22 (22.23/16.15)	VTWVALALQAAW
   33-   44 (20.50/13.89)	VLILALIFLKAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.32|      15|      15|     281|     295|      17
---------------------------------------------------------------------------
  281-  295 (25.97/16.22)	SSPLNSLYSG..LPDID
  297-  313 (22.35/12.73)	SRKRRGIYEHdiTPQLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.43|      11|      35|    1002|    1013|      18
---------------------------------------------------------------------------
 1002- 1013 (16.31/16.49)	PVGILeRRRGGH
 1039- 1049 (20.12/13.69)	PDTII.KRKIGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.34|      10|      23|     884|     893|      20
---------------------------------------------------------------------------
  884-  893 (20.00/ 9.30)	LKFMMSGPPG
  905-  914 (17.34/ 7.12)	LEVLLEPPSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07021 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEAESDTLKRNTLPTISKKSPNKENLSPSLSNNNRRINNIYDD
2) GQAKNSLTSNSNTNERGKKARKRKTGTDGLWRSPKRKSDGGDSSAATEILLESSSSENSTPLGTPTNRENLASETRTSTPTSATSLTSGMDFTNLDTTDILDKSTSDYDLDNSEKDSEIMEVQHSSAEQQQQQQQQPQQEVEELIKIRESSSTRKSKKNRSGGGSEEKKSSPTNIFVDETSTTSSGNKGLPVPPSVSITPISCGNLDQASTTNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPAPSPKTSGLTSATEDRQRSERKSGGGKSSSSSSKSSSEDTKSSGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGSAGVGLSCSSSRPTSPAAVRKFSPSPTHSSSLATLVGKSSPTLKASQSAAATCGKPVQSPKHSPVYGSTVSVPVPVPAGASPKHGSTSSPKHGSSAASSGKPSMSALKSAAPTQQRLHPKSSLLRRPRVRIPPVVEIKTDERHPSAHLAVQVVAIRVPRPSPPAVK
3) LRLSTECERPHSRVGVKHKEEVTSVNDNPDNTLTSSPLNSL
698
1349
247
740
1866
287










Molecular Recognition Features






MoRF SequenceStartStop




1) ALKSAAPTQQRLHPKSSLLRRPRVRIPPVVEIKTDERHPSAHLAVQVVAIRVPRP
2) VEELI
1806
1489
1860
1493