<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07018

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMGILYEKRPLKRPRLGPPDVYPQELKQKEDELSLTNVKHGFMATTTQLTDESGTGRNYNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGSKPLVALAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQDNGSANNQPSTPTSSSQSATGSTMNEDHKLALKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLTYLCCRKLAHMCNNVESNNNPQSPSITKNEANGSKDTTVAVQGPLNLLTVAFNDYLTCAHHRDVIYSLSTIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLPCPPAALPCPPASSSNPTMKQLRIAQENIRARSQAAEGRWSCDKWQQSSAGTTTTKVLAALDALDRHSFDKMDASNSLDTLYAKIFTPPPKDNSSERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSTCSNGSPPVLPIFQPLLMKFLDVDAPVLDNTSNQSKAQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVSDHGRTMDYDDSKIDDDLDKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRVRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAVTIKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVHEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEAQLTARNSQLVRSYTTNLSLYVVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSTCSLLKTKSHGVEAFSNAYPKIRAALYSTLQPTPSSHVYNSQFMVDVFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSNSSAFYIDVLNQVDVQDLSIHNSLAIFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDIDIEVEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAAKQPPKKVDIPLSHSTKGAMSSSSSSAGMTTENVKGFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDNMLTPRQAQKLLHMICYPETPTEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFTPSSSELSQWLDTVAKAAIDVFQLNNTLSNKSDKKSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTAGRERGRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKHIGSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSSSIRFVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAVRLERKPLTYQNAHKLLRYHTHSQIRPASHYLDPPPLPPEDLEPDKKESDPGKADTPMSIDSPGRVGGSVGSTGVGNVNTNGKGKAMKNKRHNRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPAPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQGIYAGIQQGMNQNYTGYGGQQMMQQQQQQQQQTSQQTQQQQQQQQLLQQQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYMPQQRMQPSAARPPYLQAPNVTMNAMGPMGAGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQAQQQQAAQQQQQQQQSAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
Length2166
PositionKinase
OrganismTrachymyrmex zeteki
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.06
Grand average of hydropathy-0.515
Instability index52.32
Isoelectric point8.00
Molecular weight241532.19
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07018
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     207.24|      23|      23|    1962|    1984|       1
---------------------------------------------------------------------------
 1797- 1821 (28.66/ 7.84)	QQMA.fgNQQAPVAQQPGMFTGQ..PPQ
 1924- 1951 (30.84/ 9.01)	QQGMfaaQQQQQQQQQQQQGIYAgiQQG
 1962- 1984 (45.05/16.61)	QQMM...QQQQQQQQQTSQQTQQ..QQQ
 1986- 2006 (36.46/12.01)	QQLL...QQQQQQQQQ..QGILN..QQQ
 2014- 2036 (31.11/ 9.15)	QQMM...GPQRGQEYMPQQRMQP..SAA
 2120- 2140 (35.12/11.30)	QQ.A...AQQQQQQQQ.SAAGGQ..QPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     236.54|      41|      41|    1828|    1868|       2
---------------------------------------------------------------------------
 1669- 1717 (48.31/17.35)	PA...P.....................LSwawfrA..............VRLERKP....LTYQ..N..............................AHKL..L.RYHThsqirPASHYL..DPPPLP
 1718- 1792 (33.12/ 9.78)	PEdlePdkkesdpgkadtpmsidspgrVG.....GsvgstgvgnvntngKG...KA....MKNK.................................RHNRRAK.GAAT.....PTTPIS..QQMQQP
 1793- 1846 (30.72/ 8.59)	P..................................................................sqlqqmafgnqqapvaqqpgmftgqppqpqQQWYSNQ.QTHT.....PAQQYG..YSQQLP
 1847- 1888 (68.44/27.38)	PA...P.....................VG.....G..............PRYERPG....MNNQ..S..............................KQALSNMlRLRL.....PSNQFM..GSQQQP
 1889- 1916 (25.81/ 6.14)	PT.atP.....................VA.....G..............PG.AFQG....MQRQ.fI..............................RQQLRAQ.H......................
 2074- 2116 (30.15/ 8.30)	GA..vG.....................VT.....G..............VG...TAnvslQQNQqfQ..............................QQQAINQ.R........MRQQMLamQQQQQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.12|      36|      41|      60|      99|       3
---------------------------------------------------------------------------
   60-   99 (56.55/40.18)	VTA.AKVG..AYFNAILAKKEELAtmpdTGRKRQQINPKDNFW
  101-  139 (52.57/28.08)	VTArTKNGieAWFKDLSGSKPLVA....LAKKAPNFNKKEEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.04|      43|      45|    1377|    1419|       4
---------------------------------------------------------------------------
 1341- 1386 (52.87/31.13)	LEN....LE.QWSLRMS...WLDLQLMYKqfTPSSSElsqwlDTVAKAAIDVFQ
 1387- 1429 (69.35/43.36)	LNN...TLS.NKSDKKSGSIWLVAPLVSK..LPSAVQ.....GRVLKVAGQVLE
 1430- 1466 (33.83/16.99)	SGNwskTAGrERGRSKSPSLFNHQPFLSL..VLTCLK.....GQ..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.18|      17|      45|     500|     521|       6
---------------------------------------------------------------------------
  500-  521 (26.09/26.82)	SERDTKTEYNPQQDSAvveilC
  547-  563 (31.09/19.11)	SEATGETNDNDDKDST.....C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      12|      39|    1273|    1284|       8
---------------------------------------------------------------------------
 1273- 1284 (22.54/14.07)	AHHVLRQICSQE
 1313- 1324 (23.38/14.91)	AQKLLHMICYPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.72|      19|      39|     862|     883|       9
---------------------------------------------------------------------------
  862-  883 (24.08/25.10)	ELALNIYGLI...DVCIqILKelPE
  902-  923 (29.64/17.72)	NLSLYVVGVLrryHCCL.LLS..PE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.21|      15|      15|     272|     286|      10
---------------------------------------------------------------------------
  272-  286 (25.09/15.72)	EDGILKLLLPLALQY
  288-  302 (25.12/15.75)	EEFIQSELLARRLTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.19|      31|      41|     649|     681|      12
---------------------------------------------------------------------------
  649-  681 (45.38/43.18)	IDEDSLfPGIDL..KPTKLEVSDHGRTMDYDdSKI
  692-  724 (49.81/35.37)	IKEDQQ.NSMDApdSPKEDALTGHGGHESLD.SKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.78|      10|      21|    1086|    1095|      14
---------------------------------------------------------------------------
 1086- 1095 (17.40/10.61)	NSSAFYIDVL
 1107- 1116 (16.39/ 9.58)	NSLAIFTSIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07018 with Med12 domain of Kingdom Metazoa
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