<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07015

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHPSHQTNGASLEDCHTNFFALTSLCGIKWRKLVWGEVAGGFGGTPLEDPVLSSFSRCLAGDILCVWRRAAASAPGAGIFDLGIAPSPAPPPLSLTAAKELWIFWYGEEPDLSGLVSPELIACESEQGSWESGLSYECRSLLFKALHNLIERCLLSRDFVRLGKWFVQPYNGYEKHRCSSSHLSFSFAFFVHGESTVCASVDVRQHPAVRHLTKTCLQRTQTSQSGVKVILAPYGLAGTLTGQVSRMDSQLLEEWKHFYPISTGSNPETGLPPLVEVLVGGVRMRYPSCYVLVTDMDDTPPETPLSPPSSPVTCERPLLTQQELSAATELPERVWAECTLSSPVSASKTESSTEPGTWTFVEPTQKSSCTCSCSNSKAILNDKLVNVFIKLYFKQELNYLFIIFVQKRINCTITKRLKRDVKCIGCRYTTPGGWKSLASSQIQRERVDKGGRRVVPFHRRSTTQWDACPSVPANAPRSVLSRTEAPSTPPGGPPSYSRGPPTGGDCLPVPSVGSPGSPAPSPLLTPHSEPASVPPAEPTMPTLSPQPPPSHTNTALPLTPSQGPKSISSACNNQVHSPSVPGPVLKRPILVSREYEGALLEDEQPLSWLYDYSLQEAWLNHPVKRFKSMNISAPPTNRSNVLYPPMNSQTVQSQAPKLEIKQEPVAVGECIGRRTDPYEFDATGEENGTNVDGLRRQRDDPSKPGSLFTSEGLQPSYKDLDQIFDNSDPDTSSDETNLNQLQMQTPPGSNKSGLHEETRVDGANKNNNRGVTVLRPEELSKMFPTPPSLEHNPVASPCQLSDPLMDQTELLMPSRPLRHLPDIYPNMGSPQEEPIDDWSYVPPPPPYDQPSPATSTTSSYLNKNLNSIEADTPGPARAPESNSLVVNILLGDTALNIFRDHNFDSCSLCVCNAGPKVVGNIKGADAGVYLSNSWVGSALFQDDDQIRCSCGFSAVVNRRLAHRAGLFYEDEMEITGVAEDPAEKKKGSLTAVACPGAKAAPEGLDTIPPNVLELLREQCLIVQSSASSLYRAARICATVKSYPTLTPTVNTLEFNDGNEVCVAALDQGKLDGAHNERAARVNGVHRWVFLRARGPQCSGDIVRMMRSLQPLLQDAVQKKCTTRMWEAPYTVTGPLTWRQFHRLAGRGTDDRCEPQPIPALVVGYDRDWLSLSPYAVCFWEKLSLEPFAGPRDVAYVVVAPDSDCIVSRVKSFFRELSCTYEICRLGRHTPISKQLRDGILRVGKSTVQKLAKQPMDDWFKFLGENHIGELLRLYAQVCNHRLAPYLTQVIQDRSLLDPGESQAANKQQQQQSTTIPVPDTMPATPDVLSTKPESVEGENLRSETPSSSTATNQTTTNTTGNTTPTSQSTSNTTPITTTTGPDEEEIEPPAIVVYFVEPFSLGGTEDPDRRRLAILALLRAYSSAINSMPENMRSNVHVQIISLESIMELGRARERRKIQDEMRALALNVFLQGRRLLNHNSTVKSLTGFGTAAAADIFLKSKDERNRAPYRLYAPAFVLAPLRAKSEAPESFGMPRPEECAVLYLSYCLSEDQSWLLAAATDDRGEIFETATINIDIPNRKRRKRASARRIGLQKLMDFILGVMSQGVQPWRLVVGRVGRIGHGELKGWSWLLSRKALLKASKHLKEICGQCSLLYPSAAPCVLSACLVSLEPDSTLRLMADQFTPDERFSQASVIYHSGNKSSQTAFQEQHNVPELGDDELFSALNDDMPEGMEGMGDFNDIFNVWPEPGAGGGQSPSGSPHRPEGSPHGGDGGGSGLGNHDGPGSPFPCSNTPRIATTEQAEEVGTLLQQPLALGYLVSTAPTGRMPPWFWAACPHLENVCPVFLKNALHLHSPAIQQNSDDLLQQQNAPTAHPLDSQYTTDVLRYVLEGYNALSWLALDANTKDRLSCLPVHVQALMHLYHATAALV
Length1931
PositionMiddle
OrganismTrachymyrmex zeteki
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.07
Grand average of hydropathy-0.375
Instability index58.15
Isoelectric point5.90
Molecular weight211504.73
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07015
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     831.07|     335|     429|     977|    1403|       1
---------------------------------------------------------------------------
  968- 1090 (65.97/30.49)	.........................................................................................................................................................................................................................................................................................................................................................................................FYEDEMEITGvAEDPaEKKKGSLTAVacpgAKAAPEGLDTIPPNVLELLREQcLIVQSSASSLYRAARICATVKSYPTLTPTVntleFNDGNEVCVAALDQGKLDGAHNERAARV.....NGVHRWVF
 1091- 1511 (482.23/339.08)	LRAR..GPQCSGdivrMMRslqPllqdavqKKCTTrMWEApYTVTGPLTWrqfhrLAGRGTDDRCE................PQPIPALVVGydrdwlslspyavcfWEKLsLEPFAG.......P.RDVAYVV..VAPDS....DCIVSRvKSFFRELSCTYEICrlGRHTPISKQLRDGILRV......GKSTVQKLAKQ..PmDDWFkflgenhiGEllrlyAQVCNHrlapyltqviqdrslldpgesqAANKQQQ...QQSTTIP.VPD..TMPATPDVLstkPESVE........................GENLRSE.TPSSSTATNQTTTNTTGNTTPTSqsTSNTTPITTTTGPDE..EEIEPPAIVVYFVEPFSLGG.TEDP.DRRRLAILAL....LRAYSSAINSMPENMRSNVHVQ.IISLESIMELGRARERRKIQDEMRALALNV....FLQGRRLLNHNSTVKSLTGFGTAAAADIflkskDERNRAPY
 1523- 1827 (282.87/124.53)	LRAKseAPESFG....MPR...P.......EECAV.LYLS.YCLSEDQSW.....LLAAATDDRGEifetatinidipnrkrRKRASARRIG...............LQKL.MDFILGvmsqgvqPwRLVVGRVgrIGHGElkgwSWLLSR.KALLKASKHLKEIC..GQCSLLYPSAAPCVLSAclvslePDSTLRLMADQftP.DERF........SQ.....ASVIYH......................SGNKSSQtafQEQHNVPeLGDdeLFSALNDDM...PEGMEgmgdfndifnvwpepgagggqspsGSPHRPEgSPHGGDGGGSGLGNHDGPGSPFP..CSNTPRIATTEQAEEvgTLLQQPLALGYLVSTAPTG.......................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     228.46|      61|      67|     468|     532|       2
---------------------------------------------------------------------------
  468-  515 (81.75/27.81)	.....................ACPSVPANAPRSVLSRTEA..PSTPPGGPPSYS.........RGPPTGGDC...LP..VPSVGS
  516-  581 (73.53/30.70)	PGSPAPSPlltpHSEPAsvppAEPTMPTLSPQPPPSHTNTalPLTPSQGPKSIS...............SACnnqVH..SPSV..
  770-  830 (73.18/24.77)	RGVTVLRP....EELSK....MFPTPPSLEHNPVAS.............PCQLSdplmdqtelLMPSRPLRH...LPdiYPNMGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     391.55|     130|     219|      82|     235|       3
---------------------------------------------------------------------------
   82-  235 (201.04/165.91)	DLGIAP..SPAPPPLS.............LTAAKELWIFWYGeEPDLSGLVSPELIACESEQGSW.......ESGLSYECrsllfkalHNliERCLLSRDFVRLgkwFVQPYngyEKHrcsssHLSFSFAFFVHG..ESTVCASV..DVR......QHP.AVRHLTKTCLQRTQTSQSGVKVIlaPY
  296-  458 (190.50/108.36)	DMDDTPpeTPLSPPSSpvtcerplltqqeLSAATELPERVWA.ECTLSSPVSASKTESSTEPGTWtfveptqKSSCTCSC........SN..SKAILNDKLVNV...FIKLY...FKQ.....ELNYLFIIFVQKriNCTITKRLkrDVKcigcryTTPgGWKSLASSQIQRERVDKGGRRVV..PF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.45|      15|      67|    1844|    1858|       4
---------------------------------------------------------------------------
 1844- 1858 (29.63/17.53)	C.PVFLKNALHL.HSPA
 1912- 1928 (20.82/10.13)	ClPVHVQALMHLyHATA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.57|      19|      67|     675|     694|       5
---------------------------------------------------------------------------
  675-  694 (30.72/22.67)	RTDPYEfDATGEENGTNVDG
  727-  740 (19.39/ 7.70)	NSDP...DTSSDE..TNLN.
  745-  763 (33.46/19.35)	QTPPGS.NKSGLHEETRVDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.60|      32|     216|     612|     657|       6
---------------------------------------------------------------------------
  614-  652 (48.10/57.60)	SLQEAWLNhpvKRFKSMNISAPPTNRSnvlyPPMNSQTV
  856-  887 (54.50/24.56)	STTSSYLN...KNLNSIEADTPGPARA....PESNSLVV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07015 with Med13 domain of Kingdom Metazoa
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