<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07005

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTELDDSSGKTRGCHVYVADLNMPWHAHKVLSNKHNITALEWDLPGDKLVMADTAGNVQLWMFKDHILNEWVLIGSAYFPGEHILGAAWFHNGKKTGLVTEKKDSIHYSEKFNHLLFAPSVRQFGGRAAEGVLVVSTTGMVGAIMITKDLQNPTCYSTESLGNTRHRITAVDLCYGKNGHFLVAVSSGSICLPIRCFRVLVRKNDDKCTITSQALPSFFLQDGAPKDNSCTVVTHLKFVVREDADSLVIAANSESGGFVEVWELREKSQPVHKLFQPKTLEPFKTVVWQYQSQYRCQSPVTAIATTKLSIVTTLPPPSYVIIALADSSVHCLNRLDCLKEVAFSSLNTSWRPDEPSNKYFKNSVSIAHMDLSWLGCVLLACDTQGNMYLYKLLPDGTTGTSMSLSYACTLLEYCLVTGLDWLDILLCLRSSMIEALCERLDVSFNRQLQSTQQYHYIQFLSIKTSLYRMLITGQNKAADLSSLLMIHSVATAFKSLLRPSDLISHDKGPAESLAAVITDVITDVDKVLLHLDPKEFTVEPSTLQSLQQLIQWVADLALNLLARLPEQRMQMKTGGYELLKDHKALNTVRELLVIIRIWGLLRPSCLPVFLRSADNLDVLALLFCLLSKLVQPNGDTQQQVDDGLIGKSEIHRIHEDIMTTKLAIKHKDSLVLKENKLHEKNYTIQQSRLKRYEHLSLPWSTLSVFVVYWLVLCPLIWAICYKFAYWPSYWSFLFWTVAFLIWIVIMCGLIIFWRRFQVKQSLEINTISKYGSDKERRPRSVHQISSEDSEFLRTKKWNDSHESESKSDRENLRRDLPPLVIHKQISGENIEDTDGVVCVEENEKTRLSVASDYVQKSPLQDYLKLVTVSPSEDEVKSPKTPMSPRDLFFIDLIREAEKVERSLKTRTHFFPSETTENDSAETVKSITNGTDIEDVEHRKDVKDTEDENVKDKKDNKLRSKRESNECCLLPNQIMIPQLHQGNSITAIVSPILFYQNLPLQLEYGVEPEQLVFTPEMNPVEGCMHSGQIVDTIRHLYLGRQPLLVKQCTRCGGKAQVQNMTRTAAIRAWDQRWTRACRCGGIWRIHKASQ
Length1089
PositionTail
OrganismTrachymyrmex zeteki
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.08
Grand average of hydropathy-0.199
Instability index48.52
Isoelectric point7.04
Molecular weight123715.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364149

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07005
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.38|      68|     103|     762|     834|       1
---------------------------------------------------------------------------
  762-  834 (100.18/79.63)	LEINTISKyGSDKERRPRSvhQISSEDSEFLRTKKWNDSHESESKS.....DRENLRRDLPPLVihKQIS.GENIEDTD
  863-  936 (100.20/62.45)	LKLVTVSP.SEDEVKSPKT..PMSPRDLFFIDLIREAEKVERSLKTrthffPSETTENDSAETV..KSITnGTDIEDVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.33|      23|      25|     705|     729|       2
---------------------------------------------------------------------------
  705-  729 (41.98/31.71)	FvVYWLVlCPLIWAI..CYKFAYWPSY
  732-  756 (42.36/23.50)	F.LFWTV.AFLIWIVimCGLIIFWRRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.72|      26|      27|    1026|    1052|       3
---------------------------------------------------------------------------
 1026- 1052 (43.40/31.36)	GQIVDTIRHLYL.GRQPLLVKQCtRCGG
 1054- 1080 (45.32/28.10)	AQVQNMTRTAAIrAWDQRWTRAC.RCGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.68|      16|     197|     419|     434|       4
---------------------------------------------------------------------------
  419-  434 (29.86/18.89)	LDWLDILLCLRSSMIE
  616-  631 (26.83/16.22)	LDVLALLFCLLSKLVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.44|      20|     197|      47|      66|       5
---------------------------------------------------------------------------
   47-   66 (37.14/27.97)	DKLVMA...DTAGNVQLWMFKDH
  245-  267 (29.30/20.35)	DSLVIAansESGGFVEVWELREK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.26|      38|     197|     168|     215|       6
---------------------------------------------------------------------------
  168-  215 (52.08/64.78)	ITAVDLCYgkNGHFLVAV.SSGSICLpircFRVLvrknDDKCTITSQAL
  366-  404 (67.19/47.47)	IAHMDLSW..LGCVLLACdTQGNMYL....YKLL....PDGTTGTSMSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07005 with Med16 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KTRTHFFPSETTENDSAETVKSITNGTDIEDVEHRKDVKDTEDENVKDKKDNKL
904
957










Molecular Recognition Features






MoRF SequenceStartStop




1) DLFFIDLIR
2) IWRIHK
886
1081
894
1086