<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07001

Description CREB-binding protein
SequenceMPPLLMHPAYTNYGGGGSGNMQQIQAPPQQLHLQQHPLQHWNNNTVQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALDTELRQHVQQQQQQLSHHLIQQQQGNKNLVANSLVMAAGTLGNKSPNMQSPPNVSVSKGGIVDPQMVVSLGNLPSSIASSLANNQMSIANSMGGLQSSMSMAGSNPAMSMPGGMNSGLVMTSTASGNNMGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMNTRAVAMQQQQQAHMVGPARGQSPHQQVHQVGIVGPGQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSPMQAAAAASRFTGAAGPIGTTNVVGGQEGGTAAQQAQPPAPSPAQPQSGAPTGGQPGPQQATQGQMPGAGAPTGPKSTPDPEKCRLIQQQLVLLLHAHKCQRRESQANGEMRQCTLPDCKTMKNVLNHMTNCQAGKNCTVPHCSMSRQIISHWKHCNRSDCPVCLPIKQANKNRTNSAQAPAIQPNNQPNTSPSEMRRAYEALGIQCPTTTPGILPGQGVGRGVRMPAPGMAGPPGALGNVRLAQPQTQAAPGQSVVGAGQQVVAPNVSLPLNSDPSTVGVAGNQTVPTTGPTSAAAAAAANIQQSVNMQTLFGLNESGQPGVIGGENRLANLQLPGGLQPGQVTATPVQGTKEWHLSVTPDLRNHLVHKLVQAIFPTPDPQAMLDKRMHNLVAYARKVEGDMYEMANSRSEYYHLLAEKIYKIQKELDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPPNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMAIQHNRMQFPQQQQAQQQAQQQQQVQAQQQIQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGQPQMSQANLTTTTASNNATTSQFPTSNGTTAVRLAQAQAQAAQQQQQQQQQQQQSQQQSQPTSTPSQVGTPATSIPQTPSPFSGMQQPNAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVAVTTTGTANGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPQDTTTSDIKPLVPEPIQPSGTSTDKKKCLFKPDELRQALMPTLEKLYRQDPESIPFRQPVDPQALGIPDYPTIVKKPMDLSTIKKKLDTEKYSDPWEYVDDVWMMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNRYTFCQKCFNDIPGDTVTLGDDPTQPQTAIKKEQFQEMKNDHLELEPFVTCTDCGRRVHQICVLHMEAIWPLGFTCDNCLKKKGQKRKENKFNAKRLPVTKLGTYIETRVNNFLKKKEAGAGEVAIRVVASSDKVVEVKPGMRSRFVENGDMPGEFPYRAKALFAFEEVDGTDVCFFGMHVQEYGSECTPPNTRRVYIAYLDSVHFFRPRQFRTAVYHEILLGYLDYAKQLGYTMAHIWACPPSEGDDYIFHCHPAEQKIPKPKRLQEWYKKMLDKGMVERIVLDYKDILKQAMEDRLSSAADLPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAAANAIFSLSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAKIFATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPVINCDLMDGRDAFLTMARERHYEFSSLRRAKFSSMSMLYELHNQGQDKFVYTCNNCKSHVETRYHCTVCDDFDLCVSCKDKDGHPHPMEKLGFDLDDGSSPADAKQTNPQEARKLSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVMHTKNCKRKTNGGCPICKQLIALCCYHAKHCQETKCLVPFCSNIKHKIKQQQLQQRLQQAQLLRRRMAVMNTRPTGPVAMQTGQQTSNVAMTTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHVSYTGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTARYQSNTVMQQNPNLARQQTPQQLMQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNPPLMAAFIKQRALVHQQQPGPHGGGVGGPLGPNQPQQQQPGLQHMMSQQQQPQQQQPQQQTQQQQQQGRLQIQMLTQQAQQQQPVQAQSQWYKQQMLVMQQRQQQVVQQQQQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPATMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
Length2500
PositionKinase
OrganismTrachymyrmex zeteki
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.04
Grand average of hydropathy-0.723
Instability index58.74
Isoelectric point9.21
Molecular weight271712.34
Publications









Function






Annotated function

Acetyltransferase enzyme. Acetylates histones, giving a
specific tag for transcriptional activation.



ECO:0000256	ARBA:ARBA00002581

GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
histone acetyltransferase complex	GO:0000123	IEA:InterPro

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coactivator activity	GO:0003713	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07001
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     569.61|      76|      76|    2057|    2132|       1
---------------------------------------------------------------------------
  682-  741 (70.54/15.45)	QQ.S...........V.NMQTL......FGL...N.....................................ESGQ..PGVIGG...ENRLA.NLQ...L......PG..GL........QPG.........QVTA....T.............PVQ..GTK.EWHL..............SVTPDL
  742-  890 (54.55/10.08)	RN.HlvhklvqaifpT.PDPQAmldkrmHNLvayArkvegdmyemansrseyyhllaekiykiqkeldekrqKRKE..QQQLQA...QQQQQ.QQQptQP......PGtsGPGlrpcapPNVG.........TVMPgaskP...VG.TVP...PTLRSHSPS.MGQLatipaMA.....IQH..NRM
  891-  977 (75.18/17.01)	Q...............fPQQQQ..................................................AQQQaqQQQQVQ...AQQQI.QQQ..QQgilvgpPG.pSPN......GQSTsnanmvpnpGL.S....P...FG..QP......QMSQAN.LTTT.....TAsnnatTSQFPTSN
  978- 1035 (71.59/15.80)	GT.T...........A.VRLAQ......AQA...Q.....................................AAQQ..QQQQQQ...QQQQS.QQQ..SQ......PT..........................ST....P...SQVGTPatsIP.QTPSPF.S.........G.....M.......
 2057- 2097 (59.26/11.66)	..............................................................................................................GVG......GQTG.........GVMP....P...PQMQRP...LPVQMPNPS.GTHL.....IP.....MDQWTARY
 2098- 2171 (110.99/29.04)	QS.N...........T.VMQQN......PNL...A.....................................RQQT..PQQLMQ...QQQQQ.QHQ..AQ......PG.mGMG......AQMA......rqpGVIG....P...VG........QVG.PQAS.TMHK.....HA.....LQQLMQTL
 2172- 2237 (66.80/14.19)	RSpH...........T.PDQQN......QIL...Q.....................................ILKS..NPPLMAafiKQRAL.VHQ..QQ......PG....................phggGVGG....P...LGPNQP......QQQQPG.LQHM.....MS.............
 2238- 2292 (60.71/12.15)	..................QQQQ......P...........................................QQQQ..PQQQTQ...QQQQQgRLQ..IQ.........................................mltQQAQQQ...QPVQAQSQWyKQQM.....LV.....MQQ...R.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     378.69|      70|      72|    2338|    2407|       2
---------------------------------------------------------------------------
 1036- 1113 (80.83/21.36)	......QQPNAQQPQQQPQQQSNQQF.PTRP...LSATTP.NDNGIATSTPQTIPPPAssgPSPTGgvavtttgtANGPqsttstP.NTP
 1114- 1162 (79.75/20.95)	LVPSLM....TPNQTVSSASNQTP.P......H.....SGPTPQDTTTSDIKPL...V...PEP............IQP......S.GTS
 2296- 2375 (127.81/39.01)	VVQQQQQQQQQQQQQQQQQQQQQQQPfTQPPAPPLLGYGGFNEQGYGQPGLKPTPPPV...PSPQG.........VMGP......P.GIS
 2376- 2428 (90.30/24.92)	VQQQLMQSVRSPPPIRSPQPNPSPRP.VPSPRN..............QPVPSPRSGPV...PSPH...........HHP......PhG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     302.08|      33|      35|     284|     316|       3
---------------------------------------------------------------------------
  145-  164 (31.69/ 9.25)	M.Q....................S..........PPNVSVSKGGIVDP.QMV
  189-  216 (36.12/12.08)	M.G.GLQSSMSMA...G......S..........NPAMSMP..GGMNS.GLV
  217-  257 (28.06/ 6.92)	MtS.TASGNNMGGMAGGslivtnS..........LNKQPLNTVTMMGPnTQA
  258-  277 (32.84/ 9.98)	I........HHPGAPHG......V..........TPMQN.......GP.GMM
  284-  316 (61.73/28.45)	M.Q.QQQQAHMVGPARG......Q..........SPHQQVHQVGIVGP.GQG
  320-  354 (33.66/10.50)	M.QaPPNMANM..PTMG......QlgasnpysygSPN.......TVGP.GAG
  380-  407 (34.46/11.02)	M.Q.AAAAASRFTGAAG..................P...IGTTNVVGG.QEG
  419-  448 (43.53/16.81)	..P.SPAQPQSGAPTGG......Q..........PGPQQATQ.GQM.P.GAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.12|      14|      16|     582|     597|       4
---------------------------------------------------------------------------
  582-  597 (23.84/16.02)	GIQCPttTPGILPGQG
  601-  614 (24.28/ 9.48)	GVRMP..APGMAGPPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.02|      30|      72|      17|      50|       5
---------------------------------------------------------------------------
   17-   46 (60.26/30.29)	GSGNMQQIQAPPQQL..HLQQ.......HPLQHW..NNNTV
   87-  127 (39.76/11.36)	GPGPGQQNGALDTELrqHVQQqqqqlshHLIQQQqgNKNLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     245.33|      66|      72|    1488|    1559|       7
---------------------------------------------------------------------------
 1444- 1482 (47.46/24.12)	..........................RV.VASSDKVVEVKP.GMRSRFVEN...G..DMPGE...........FPYRAKALFA..
 1488- 1559 (106.65/91.57)	GTDVCFFgMHVQEygsECTPPNTR..RVYIAYLDSVHFFRPrQFRTAVYHEILLGYLDYAKQ...........LGYTMAHIWAcP
 1563- 1630 (91.21/57.18)	GDDYIFH.CHPAE...QKIPKPKRlqEWYKKMLD..........KGMV.ERIVLDYKDILKQamedrlssaadLPYFEGDFW..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     219.90|      41|      50|    1852|    1892|       8
---------------------------------------------------------------------------
  454-  481 (30.96/12.20)	.....................KSTpD...PEKC.RL.IQQQLVL...LLHAHKCQRR
  491-  537 (66.70/35.46)	QCTLPDCKTMKN......vlnHMT.N...CQAGKNCTVPHCSMSrqiISHWKHCNRS
 1852- 1880 (40.35/18.31)	.....................KQT.N...PQEARKLSIQRCIQS...LVHACQCRDA
 1881- 1928 (56.13/28.58)	NCRLPSCQKMKRvvmhtknckRKT.NggcPI.CKQL.IALC......CYHAKHCQET
 1929- 1951 (25.76/ 8.81)	KCLVPFCSNIKH.........KIK.Q...QQLQQRL.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.51|      22|      73|    1185|    1206|       9
---------------------------------------------------------------------------
 1185- 1206 (39.89/22.36)	KLYR.QDPESIPFRQPVDP..QALG
 1225- 1244 (28.19/13.37)	KKLD.TEKYSDPW.EYVDD..VWM.
 1258- 1282 (26.43/12.02)	RVYRyCTKLSEVFEQEIDPvmQALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.89|      31|      72|    1291|    1326|      10
---------------------------------------------------------------------------
 1286- 1325 (40.82/55.37)	G...............................rkytFNPQVLC..CyGK...QLCTIPRDAkyYsYQNRYTfCQKC
 1326- 1396 (37.06/24.91)	FndipgdtvtlgddptqpqtaikkeqfqemkndhleLEPFVTCtdC.GRrvhQICVLHMEA..I.WPLGFT.CDNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      40|      49|    1707|    1752|      11
---------------------------------------------------------------------------
 1707- 1751 (59.91/57.96)	GNDlsAkiFATM..EKHKEvFFVIRLHSAQSAASLAPI..QDPDPVI....NC
 1756- 1803 (59.49/35.20)	GRD..A..FLTMarERHYE.FSSLRRAKFSSMSMLYELhnQGQDKFVytcnNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.19|      15|      16|    1980|    1994|      12
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 1980- 1994 (28.15/12.92)	TSNVAMT..TGVAMKPG
 1997- 2013 (23.04/ 8.93)	TSNLPTPhqPGIGLKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.17|      11|      35|    2430|    2440|      15
---------------------------------------------------------------------------
 2430- 2440 (22.16/ 7.40)	PTHSPAHELGG
 2457- 2466 (21.58/ 7.00)	PTGHPA.TMPH
 2468- 2478 (22.43/ 7.59)	PSPAPAPTNGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07001 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANSLVMAAGTLGNKSPNMQSPPNVSVSKGGI
2) ILPGQGVGRGVRMPAPGMAGPPGALGNVRLAQPQTQAAPGQSVVGAGQQVVAPNVSLPLNSDPSTVGVAGNQTVPTTGPTSAAAAAAA
3) LLRRRMAVMNTRPTGPVAMQTGQQTSNVAMTTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHVSYTGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTARYQSNTVMQQNPNLARQQTPQQLMQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNP
4) LSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAK
5) MAAFIKQRALVHQQQPGPHGGGVGGPLGPNQPQQQQPGLQHMMSQQQQPQQQQPQQQTQQQQQQGRLQIQMLTQQA
6) MGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMNTRAVAMQQQQQAHMVGPARGQSPHQQVHQVGIVGPGQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSPMQAAAAASRFTGAAGPIGTTNVVGGQEGGTAAQQAQPPAPSPAQPQSGAPTGGQPGPQQATQGQMPGAGAPTGPKSTPDPEKCRLIQ
7) MPPLLMHPAYTNYGGGGSGNMQQIQAPPQQLHLQQHPLQHWNNNTVQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALDTELRQHVQQQQQQLSHHLIQQQQGNKN
8) QKELDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPPNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMAIQHNRMQFPQQQQAQQQAQQQQQVQAQQQIQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGQPQMSQANLTTTTASNNATTSQFPTSNGTTAVRLAQAQAQAAQQQQQQQQQQQQSQQQSQPTSTPSQVGTPATSIPQTPSPFSGMQQPNAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVAVTTTGTANGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPQDTTTSDIKPLVPEPIQPSGTSTDKKKCLFKPDE
9) QQQVVQQQQQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPATMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
10) RTNSAQAPAIQPNNQPNTSPSEMRRAYEAL
11) SSLANNQMSIANSMGGLQSSMSMAGSNPAMSMPGGMNSGLVMTSTASG
128
592
1956
1667
2194
226
1
803
2293
552
176
158
679
2191
1713
2269
466
125
1174
2500
581
223










Molecular Recognition Features






MoRF SequenceStartStop




1) RPIRPLLGYGGF
2334
2345