<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06984

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELSTLVTRAAHDSYASLKELVDKCRSSELSDTDKKISILKFLSKTQQRMIRLNVPLIQHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCIEDVGTQYALTEDQQKPALKKLDMLVRSKLLQLSIPKDFSDIKVSDGTATLRVDGEFKVLITLGYRGHLSLWRILHLELLVGEKNKPVKLEELRRHILGDDLERRMAAAENPFSVLYSVLHELCVALVMDTVLRQVQVLRQGRWKDAIRFELISDSHGASSSSAQNPDGESDSSALRTPGLKIVYWLDFDKNAGVSESGTSPFIKIEPGPDLQIKCLHSNFVIDPLTGKEAEFILDQSCIDVERLLLRAICCNRYTRLLEIKRELVKNVQVCRTADDVVLQSRMGEPDIEYKQKDDKCGSKVSEGHEVLRVRAYGSSIFTLGINIRNGRFLLKSSQNIVVSSALLECEEALNQGSMTAAEVFISLRSKSILHLFASIGRVLGLEVYEHGFSTVKIPKEVSNGSAMLLMGFPDCGSSYFLLLMQLDKDFKPLFKLLETQPDPSGKDNLSGGDLNQVLRIKKIDIGQMQVHEDEMNLSLVDWGKLCSVLPNAVCSNQTSGHEFFSDIRLENSVQVARGHPSGFSSLVDEVFGLEKGSSAPPFSMNASLPSQYGSVPMNLHTLKAGSPSPKWEGGMQMSQVNNVLKASGATNHYSGSLFTSGSMKGPVQSTDISSSAAMDEEQLRVLSDTSNDALSGSRPNGPQVESFKAAGSGSCATTPVSQPLEPTTSYSTGEDVTSKNDKKSRKRTASDMLTLIPSLQGVENNPGICKKRKISDSSNCQLSLPQGAMSTDMIPKTEGYSYGSLIAEANKGNVPSSIYIAALLHVVRHCSLCLKHARLTSQMDALDISYVEEVGLRNASSNIWFRLPFARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGSNNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRKLLGVRADEKSEELVTSSDTKTSGGAKGASDTADKLSEQMRRAFRIEAVGLMSLWFSFGSSVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSPLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQTGGYISSQGLLLGNSTTNVGQPTSGPGANTVLPTASGLTNQQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKLFAIDMRCFAGDQVWLQPATPPKEGPLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLANSNNPNPSSGSQMMAANGNRINLPISAAMSRTGNQVASLNRVGNALAGSSNLAMMTSAVSLRRPPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGVLKYLGVLWLFAQLPNLLKEILGSILKENEGALLNLDLEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPAPEELSQSEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQAQVGDVVSAQKPRIELCLENHSGLNVDENSESSSTFRSNIHYDRLHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESPNVSFLGMNGSHGGRACWLRVDDWEKCKQRVARIVEVNGSSATDVSQGRLKLVADSVQRNLHMCIQGLRDGSGVTSSSGAT
Length1746
PositionTail
OrganismCajanus cajan (Pigeon pea) (Cajanus indicus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Cajanus.
Aromaticity0.06
Grand average of hydropathy-0.167
Instability index40.52
Isoelectric point7.09
Molecular weight190129.64
Publications
PubMed=22057054

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06984
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.54|      45|     118|    1159|    1203|       1
---------------------------------------------------------------------------
  673-  725 (66.13/35.26)	PSQYGSVPmnlHTLKAGSPSPKWEGGMQMSQvnNVLKASGATNhySGSlFTSG
 1159- 1203 (81.41/45.16)	PARAGPVP...GVAAALSSIPKQTGGYISSQ..GLLLGNSTTN..VGQ.PTSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.01|      68|     392|     475|     642|       3
---------------------------------------------------------------------------
  105-  185 (99.49/36.99)	VYD.......VPSAID....ILLTGsyqrLPKCiedvGTQYALTEDQQKPALKKLdmlvrSKLLQLSI.PKDFSDIKVSDGTATLR...VD.GEFKV
  511-  594 (96.52/158.45)	VYEhgfstvkIPKEVSngsaMLLMG....FPDC....GSSYFLLLMQLDKDFKPL.....FKLLETQPdPSGKDNLSGGDLNQVLRikkIDiGQMQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.87|      29|     388|     614|     642|       4
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  614-  642 (53.55/35.87)	PNAVC.SNQT....SGHEFFSDI.RLENSVQVARG
  998- 1032 (34.32/20.16)	PDGVVlSYQSvevdSIKKLVADIqRLANARTFALG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06984 with Med14 domain of Kingdom Viridiplantae
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