<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06949

Description Putative mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHAGSCTSAVNNNTIGGPSARDTGRSDSPSLPANFSVSSRRQPPLNPYKLKCDKEPLNSRLGAPDFHPQTPNCPEETLTREYLQSGYRDTIEGLEEAREISLTQVPNFNKQIVLNCKEAIRKRLRAINESRAQKRKLILDLVQSTAVYLIYGVPLSGSQLARSGVFPELRPCGEDFQKKWIEGLSQQHKRLRTLADHVPHGYKRTSLLEVLIRNNVPLLRATWFIKVTYLNQVRPGSAGISSGTADKIQLSRSDVWTKDVINYLQTLLDEYLSKNASHSASHGRERSPQMPYTGSLQNKSEPLLSVSDGERPSLHFRWWYIVRLLQWHHAEGLLHPSLVIDWVFDFSHLCSFQEKELLEVWQLLLPIIYGFLETIVLSQTYVRTLAGLALRVIRDPAPGGSDLVDNSRRAYTTYALIEMLRYLILVAPDTFVALDCFPLPSSVISHIMNDGRFVLKSTEAAGKIKNSSDDFGHIISCIQKHTEDLAKAASPGYPGNCLAKVAKALDKALVLGDLRVAYKFLFEDLCGGTVSEGWVAKVSPCLRLSLKWFGTVNTPLIYSVFFLCEWATCDFRDFRSTPPRDIKFTGRKDISQVHIAVRLLKMKMRDVKISLKQTNEIHRAIIFESPGPLHDIIVCWIDQHVVHKGEGPKRLHLFIVELIRAGIFYPLAYVRQLIVSGIMDVNVNVVDLERRRRHYRILKQLPGCFIHDVLEESGIVEGQQLKESLQIYLNERRLILRGPLSDPHDDAMTIDQKRRTVISTTVSSNNAKDNATVEELKTAISVLLQLPNCLSNLSTTGCDDSDGSVRRPIGSHYSKNDPVEGTPGCEECSRAKRQKLSEERSSFVQGHSPVQSDDDDTWWMKKGMKSLEPTKVDQPQKSTKQVTKSRQKNVRKTHSLAQLAASRIEGSQGASTSHVCGNKVSCPHHRTSVDGDGQRSVDSIRTSHFGDIVSIGKALKQLRFVEKRAIAVWLLTVVRQAIQEMEKNVGKVGQFGRPFAVVDDKSTIRWKLGEDELSVILYLMDISDDLVSAVKFLLWLLPKVLNSPNSTIHSGRNVLMLPRNVENHVCDVGEAFLLSSLRRYENILVAADLIPEALSSAMQRAATVISSNGRVSGSGAMAFTRYLLKKYSNVASVIEWERNFKTTCDARLSSELESGRSVDGESGLPLGVPAGVEDHDDFFLVGLIDCIRQTGGAAQEGDPSLVSSAVSAIVGSVGPTLAKMPDFSSGNNHSNTILATNSLNYARCILRMHITCLCLLKEALGERQSRVFDIALATETSTALAGVFTPTKASRAQFQMSPEGHDTSSTVSNDTGSNSNKVVVAKTTKIAAAVSALLVGAIIYGVTSLERMVTVLRLKEGLDAVQFVRSTRSNSNGNARSVMAYKVDSSIEVHTHWFRLLVGNCRTVCEGLVVELLGEPSIMALSRMQRMLPLNLVFPPAYSIFAFVKWRPFIQNATVREDMNQIYQSLTMAITDAIKHLPFRDVCFRDCQGLYDLMAADASDSEFATLLEFNGSDMHLKSTAFVPLRSRLFLNAMIDCKMPQSISGAGESKIKFTDSESKLQDMLVHVLDTLQPAKFHWQWVALRLLLNEQALIEKLENHDVSLADAIQLSSPSPEKAAAASENENNFIQILLTRLLVRPDAAPLFSELIHLFGRSLEDSMLLQAKWFLGGQDVLFGRKTIRQRLHNIAENKGLSVKTQFWEPWGWCSPSADPLTIKGDKKKIDSISLEEGEVVEEGMDLKSNQQQLTERALIELLLPCIDQSSDESRNSFANDLVKQLNYIEQQITAVTGGSKTVGSAPPGVEGQPSKVNNRKNMRNVNAALARRPTVAVDSSPPSPAALRASMSLRLQLLLRFLPILCTDREPSVRSTRQFLATVVFRLLGSRVVHEDADFSVNAVPSLPRKEAESSSEVAFATLVDSSSGNLFDRLLLVLHGLLSSYPPSWLRTKPVSKTINESTRDFSGIDRELLETLQKCHFNLPSCTCLMFCCLTQNDLDRMQLPDTIRWHIQAAMPLLIPSTRCSLSCQQPAVSNSALVSLQPSITNPGFNSSSSTVPQRNPVLSRNASGKSKQQDNDLEIDPWTLLEDGAGSYPSAGNTASIGSGDHVNIRAASWLKGAVRVRRTDLTYVGAVDDDT
Length2136
PositionKinase
OrganismCajanus cajan (Pigeon pea) (Cajanus indicus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Cajanus.
Aromaticity0.07
Grand average of hydropathy-0.201
Instability index49.76
Isoelectric point8.49
Molecular weight236959.26
Publications
PubMed=22057054

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06949
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.52|      36|     995|     713|     749|       1
---------------------------------------------------------------------------
  713-  749 (61.05/39.76)	LEESGIV.EGQQLKeSLQIYLNERRLI.LRGPLSDPHDD
 1729- 1766 (55.47/31.64)	LEEGEVVeEGMDLK.SNQQQLTERALIeLLLPCIDQSSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.34|      30|     995|    1006|    1063|       2
---------------------------------------------------------------------------
  419-  458 (38.23/ 8.26)	LIEMLRYLILVAPDTFVAldcfplPSSVIshimNDGRFVL
 1029- 1058 (52.12/94.37)	LVSAVKFLLWLLPKVLNS......PNSTI....HSGRNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.74|      76|     603|    1194|    1277|       3
---------------------------------------------------------------------------
 1194- 1277 (109.04/100.40)	GGAAQ..EGDPSLVSSAVSaiVGSVGPTLAKMPDFS..SGNNHSNTILATNSLNYaRCILRMhITCLCLLKEAlGERQSRVFdiaLAT
 1798- 1877 (118.71/79.96)	GSAPPgvEGQPSKVNNRKN..MRNVNAALARRPTVAvdSSPPSPAALRASMSLRL.QLLLRF.LPILCTDREP.SVRSTRQF...LAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.78|      28|     996|     159|     187|       4
---------------------------------------------------------------------------
  159-  187 (49.36/30.77)	SGSQL.ARSGvFPELRPCG.EDFQKKWIEGL
 1157- 1186 (42.42/21.91)	SGRSVdGESG.LPLGVPAGvEDHDDFFLVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.86|      46|    1558|     516|     561|       7
---------------------------------------------------------------------------
  516-  561 (84.96/45.57)	DLRVAYKFLFEDLCGGTVSEGWVAKVSPCLRLSLK...WF.GTV...NTPLIY
 2076- 2128 (68.91/35.63)	DLEIDPWTLLEDGAGSYPSAGNTASIGSGDHVNIRaasWLkGAVrvrRTDLTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.97|      61|     348|    1062|    1123|      10
---------------------------------------------------------------------------
 1062- 1123 (97.36/59.64)	RNV.ENHVCD.VGEAFLLsSLRRYENILVAADLIPEALS.......SAMQRAATVISSNGRVSGSGAMAFT
 1405- 1474 (90.61/51.39)	RTVcEGLVVElLGEPSIM.ALSRMQRMLPLNLVFPPAYSifafvkwRPFIQNATVREDMNQIYQSLTMAIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.40|      28|    1556|     105|     132|      11
---------------------------------------------------------------------------
  105-  132 (48.97/36.86)	LTQVPNF.NKQIVLNCKEAIRKRLRAINE
 1663- 1691 (46.42/34.49)	LLQAKWFlGGQDVLFGRKTIRQRLHNIAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06949 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSDGSVRRPIGSHYSKNDPVEGTPGCEECSRAKR
2) LSEERSSFVQGHSPVQSDDDDTWWMKKGMKSLEPTKVDQPQKSTKQVTKSRQKNVRKTHSLAQLAASRI
3) TGGSKTVGSAPPGVEGQPSKVNNRKNMRNV
4) YHAGSCTSAVNNNTIGGPSARDTGRSDSPSLPANFSVSSR
803
839
1791
4
836
907
1820
43










Molecular Recognition Features






MoRF SequenceStartStop




NANANA