<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06894

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLESAQLVPAGGGGGGPGSAPAPPAPGAVTAPASPGYRLSGLIEFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKNCNANDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFHLMLYGIDQLTLDDVEKSVNDDMKRIIPWLQQLKFWLGQQHCKQSIKHLPTVSSETLQLANYASHPVGSLSKHKLFIKLTRLPQYYIVVEMFEVPGNPTELEYKYHFLSVSCAEGDDSPATALLLQQFKPNIEELVLDTRSGKQAKSGAKRKLSGDPCSVEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRIELSNMDIPHQGLQVEGDGFSHAIRLLKIPPCKGVSEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLSSTTSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSFPDIPNHLNVFSEVRVYNYRKLILCYGTTKGSSISIQWNSVLQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQQQQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMIHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAVQWKPEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMLNLTLPPGGRP
Length1451
PositionTail
OrganismAlligator mississippiensis (American alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.06
Grand average of hydropathy-0.179
Instability index54.99
Isoelectric point8.77
Molecular weight160284.28
Publications
PubMed=22293439

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06894
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     191.32|      33|      33|    1031|    1063|       1
---------------------------------------------------------------------------
  998- 1033 (44.42/14.76)	PQQQQ.QQQPFAKQAGASGAYPLTSP.PTSYhntvTP.S
 1034- 1068 (56.79/20.70)	PSMIH.TQSPGNLHAASSPSGALRAPSPASF..gpTP.S
 1069- 1094 (31.36/ 8.48)	PSSLG.I.TMGQTANFASPHGTIDPSSP...........
 1096- 1129 (26.78/ 6.29)	.TMMSpSQRAGNWPGSPQVSG....PSPAARmpgmSPaN
 1171- 1200 (31.96/ 8.78)	IPTIL.THSALNILLLPSPTPGLVPGLAGSY........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     589.02|     186|     510|     170|     377|       2
---------------------------------------------------------------------------
   47-  164 (94.11/49.05)	..................................................................................................IEFlLHRtYAELTV.LADLLPRKtDMERKIEIVQFASRTRQLFVRLLALV..KWANNAgKVE.....KCAMISS.FlDQQaILFVDTAdrLASLARdalVHARLPSFAIPYAIDVlttGSYPRLPTC
  170-  373 (303.05/245.14)	IPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVAN...GRVKFRVEGefeatltvmgddpdiPWRLLKLEILVEDKETGDGRALVHSM..QINF.IHQ.LVQSRL.FADEKPLQ.DMYNCLHSFCLALQLEVLHSQTLMLIreRWGDLV.QVErYHAGKCLSLSV.W.NQQ.VLGRKTG..TASVHK...VTIKIDETDVSKPLQI...SHEPPLPAC
  679-  817 (191.86/124.46)	IPPCKGVSEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANcplSSTTSREQG...............PTRHVYLTYENQLSEPVGGRKVVEMFlnDWNS.IAR.LYECVLeFARSFP...DIPNHLNVFS...EVRVYNYRKLIL...........C..YGTTKGSSISIqW.N.................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     200.14|      54|     401|     853|     918|       3
---------------------------------------------------------------------------
  853-  906 (93.70/46.79)	KTPNVVQLLQVLFDTQAPLNAINKLPTVPM.......LGLTQRTNTAYQCFSILPQSPTHI
 1276- 1310 (43.73/17.06)	..................LQVLEKFFETRV.......AGPPFKANTLI.AFTKLLGAPTHI
 1329- 1381 (62.71/32.72)	QLKWNVQFCLTIPPSAPPI.APPGTPAVVLkskmlffLQLTQKTTVPQEAVSII.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.38|      20|     398|     566|     586|       7
---------------------------------------------------------------------------
  566-  586 (31.96/22.94)	SCAEgDDSPATAL.......LLQQFKPN
  969-  995 (30.42/16.33)	SVNE.DDNPPSPIggdmmdsLISQLQPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06894 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQQQQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMIHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
962
1168










Molecular Recognition Features






MoRF SequenceStartStop




NANANA