<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06889

Description Mediator of RNA polymerase II transcription subunit 12 isoform A
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGNKPLPILAKKVPILSKKEDVFAYLAKYSVPLLRAAWLVKMTCAYYAAISEAKLKKRQATDPNIEWTQILTRYLREQLAKIAEFYHVTTNQGNGSVAVPQEVEQALKQWEYNEKLAFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDSPNLVAAHSPHMIIGSNNPPLAAPSPTTPGPMVSPVQLACSDLFSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSINPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDSQEVAPNDEAVVTLLCEWAVSCKRSGKYRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSEYEKTEFVNLVLLFSEFIRHDVFSHDAYMCTLISRGDLSITTATRPRSPTGETVDEHYSKDHDMKLEDHSIMEHMGIDSGTTNIFDDVDRNDFKTDFGSEFPIFSPMPAESCENVNSSLDRRISVNSEKTVKRERLKDLIFPSNYDLRHLQYATHFPILLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKIGDEGQKARKNKQEAFPTLETVFTKLQQLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNSLMNVCMGHQDAGRINDIANLCAELTACCTMLSSEWLGVLKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVYLFSQATGKSFPGIRSSCDRHLLTAAHNSIEVGAVFAVLKAILMLGDAEIGSSSINSLKNEDFSMRGLLDDLDDDEIWGASHTLTSCGKAISIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRNTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGSEENKRAYMNLVKKLKKELGDKHSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHMHPKPKPRSYYLEPLLLPPEEEEEEPTTPVSQEPERKSSELSDQGKPNTDDEKKSKGRKRKTKSNSRADEYPQNNIYRVPTTYSPISSQMMHHPQSALWGYNIMGQPQQPGFFVQNQPLPPGGSRLDPAGSFVPTNTKQALSNMLQRRSGTMMQPPSIHAITSQQQLLQMKLLQQQQQQQQRLLRQQTQTRTFQQGQPIDQAAIFTQQVRPSSQLPQYPGLQQAQTMPHGYTMYSTQMPLQQQQPGGVVLSPSYNPRTYPATHSNPSLIERLRQMQQQPSGYIQQQAAAYLQPLTGTQRLTHQPLQQSSLVGGALENVPSTAPHPNLNSVQLPQEQMRQRQQQIRQQRLLQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVNQYGHPSHF
Length2137
PositionKinase
OrganismAlligator mississippiensis (American alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.07
Grand average of hydropathy-0.430
Instability index54.87
Isoelectric point6.75
Molecular weight240331.61
Publications
PubMed=22293439

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06889
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     539.21|     161|     182|    1764|    1943|       1
---------------------------------------------------------------------------
 1446- 1521 (59.41/21.21)	.....................................................................................................LIAKLPTSVQGRVL...........KAAGEELEKG..QHLGSSSKKERDRQKQ.KSM.SLLSQQPFLSLVLtcLK......GQDEQREG...LLTSlQNQ............
 1764- 1943 (250.63/172.64)	EEEEPTTPVSQEPERKSSELSDQGKP..NTD...DEKKSKGRKRKTKSNSRAdeypqnniYrvPTTYSPIS.....SQMMHHPQsalwGYnImgQPQQPGFFVQNQPLPPGGSRL...........DPAGSFVPTNTKQALSNMLQRRSGTMMQpPSIhAITSQQQLLQMKL..LQ......QQQQQQQR...LLRQ.QTQTRTFQQGQPIDQ
 1949- 2130 (229.16/119.10)	QQVRPSSQLPQYPGLQQAQTMPHGYTmySTQmplQQQQPGGVVLSPSYNPRT........Y..PATHSNPSlierlRQMQQQPS....GY.I..QQQAAAYL...QPL.TGTQRLthqplqqsslvGGALENVPSTAPHPNLNSVQLPQEQMRQ........RQQQIRQQRL..LQfprqglQQTQQQQQtaaLVRQlQKQLSSNQPQQGVNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.85|      11|      85|    1060|    1073|       4
---------------------------------------------------------------------------
 1060- 1070 (20.68/17.17)	ANLCAELTACC
 1076- 1086 (21.18/ 7.34)	EWLGVLKALCC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     216.41|      73|     203|     893|     991|       8
---------------------------------------------------------------------------
  893-  991 (110.19/120.72)	LLKSSSLAG.SYTTGLCVCIVAVLRRyhaclilnpdqtaQVFeGLCGVVKHVVNPS....ECSSPE.......RC.ILAYLY...DLYvscshlrskfgdLFSSACSKVKQTIYS
 1097- 1185 (106.22/66.30)	LLCSVDVSDlSFHDSLATFIAILIAR.............QCF.SLEDVVQHVALPSllaaACGDPDaepgarmTCrLLLHLFrtpQVY............LFSQATGKSFPGIRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.43|      44|     202|    1380|    1432|       9
---------------------------------------------------------------------------
 1380- 1432 (62.43/55.87)	LLDNIAKATI......EVFQQSADLNnnssnsgiGLFnPNSVGNADTSNTRQNG....KKTFL
 1576- 1629 (60.00/34.53)	LLQIITSGTVdmqtnnELFTTVLDML........GVL.INGTLASDLSNASQGGseenKRAYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.98|      30|     202|     222|     260|      10
---------------------------------------------------------------------------
  231-  260 (52.44/29.17)	EYNEKL.AFYMFQEGMLERHEYLTWILDVLE
 1533- 1563 (46.54/45.39)	RYQDDVkARQMMHEALQLRLNLVGGMFDTVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.98|      30|     185|    1016|    1045|      13
---------------------------------------------------------------------------
 1016- 1045 (55.73/37.66)	AH.SIN....YSMLGKILSDNAANRYSFVCNSLMN
 1195- 1229 (39.25/24.20)	AHnSIEvgavFAVLKAILMLGDAEIGSSSINSLKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.98|      13|      36|    1705|    1717|      19
---------------------------------------------------------------------------
 1705- 1717 (26.40/15.81)	LFEGHKNPAPLSW
 1740- 1752 (27.58/16.90)	LYHMHPKPKPRSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.99|      36|      39|    1243|    1279|      20
---------------------------------------------------------------------------
 1235- 1255 (19.56/10.38)	.................RGLLDDLDDDEiWGASHTLTS
 1256- 1291 (63.14/36.06)	C.GKAISIETASLSEYARYVLRTICQQE.WVGEHCLKE
 1296- 1320 (26.29/10.59)	CtDKDLILDPVLSNKQAQKLLQLIC.............
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06889 with Med12 domain of Kingdom Metazoa
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