<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06888

Description Mediator of RNA polymerase II transcription subunit 12 isoform B
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGNKPLPILAKKVPILSKKEDVFAYLAKYSVPLLRAAWLVKMTCAYYAAISEAKLKKRQATDPNIEWTQILTRYLREQLAKIAEFYHVTTNQGNGSVAVPQEVEQALKQWEYNEKLAFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDSPNLVAAHSPHMIIGSNNPPLAAPSPTTPGPMVSPVQLACSDLFSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSINPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDSQEVAPNDEAVVTLLCEWAVSCKRSGKYRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSEYEKTEFVNLVLLFSEFIRHDVFSHDAYMCTLISRGDLSITTATRPRSPTGETVDEHYSKDHDMKLEDHSIMEHMGIDSGTTNIFDDVDRNDFKTDFGSEFPIFSPMPAESCENVNSSLDRRISVNSEKTVKRERLKDLIFPSNYDLRHLQYATHFPILLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQEAFPTLETVFTKLQQLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNSLMNVCMGHQDAGRINDIANLCAELTACCTMLSSEWLGVLKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVYLFSQATGKSFPGIRSSCDRHLLTAAHNSIEVGAVFAVLKAILMLGDAEIGSSSINSLKNEDFSMRGLLDDLDDDEIWGASHTLTSCGKAISIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRNTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGSEENKRAYMNLVKKLKKELGDKHSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHMHPKPKPRSYYLEPLLLPPEEEEEEPTTPVSQEPERKSSELSDQGKPNTDDEKKSKGRKRKTKSNSRADEYPQNNIYRVPTTYSPISSQMMHHPQSALWGYNIMGQPQQPGFFVQNQPLPPGGSRLDPAGSFVPTNTKQALSNMLQRRSGTMMQPPSIHAITSQQQLLQMKLLQQQQQQQQRLLRQQTQTRTFQQGQPIDQAAIFTQQVRPSSQLPQYPGLQQAQTMPHGYTMYSTQMPLQQQQPGGVVLSPSYNPRTYPATHSNPSLIERLRQMQQQPSGYIQQQAAAYLQPLTGTQRLTHQPLQQSSLVGGALENVPSTAPHPNLNSVQLPQEQMRQRQQQIRQQRLLQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVNQYGHPSHF
Length2143
PositionKinase
OrganismAlligator mississippiensis (American alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.07
Grand average of hydropathy-0.432
Instability index54.79
Isoelectric point6.70
Molecular weight240894.13
Publications
PubMed=22293439

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06888
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     539.21|     161|     182|    1770|    1949|       1
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 1452- 1527 (59.41/22.71)	.....................................................................................................LIAKLPTSVQGRVL...........KAAGEELEKG..QHLGSSSKKERDRQKQ.KSM.SLLSQQPFLSLVLtcLK......GQDEQREG...LLTSlQNQ............
 1770- 1949 (250.63/185.63)	EEEEPTTPVSQEPERKSSELSDQGKP..NTD...DEKKSKGRKRKTKSNSRAdeypqnniYrvPTTYSPIS.....SQMMHHPQsalwGYnImgQPQQPGFFVQNQPLPPGGSRL...........DPAGSFVPTNTKQALSNMLQRRSGTMMQpPSIhAITSQQQLLQMKL..LQ......QQQQQQQR...LLRQ.QTQTRTFQQGQPIDQ
 1955- 2136 (229.16/128.03)	QQVRPSSQLPQYPGLQQAQTMPHGYTmySTQmplQQQQPGGVVLSPSYNPRT........Y..PATHSNPSlierlRQMQQQPS....GY.I..QQQAAAYL...QPL.TGTQRLthqplqqsslvGGALENVPSTAPHPNLNSVQLPQEQMRQ........RQQQIRQQRL..LQfprqglQQTQQQQQtaaLVRQlQKQLSSNQPQQGVNQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     453.42|     152|     203|     899|    1091|       2
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  899- 1091 (241.94/243.70)	LLKSSSLAG.SYTTGLCVCIVAVLRRyhaclilnpdqtaQVFeGLCGVVKHVVNPS....ECSSPE.......RC.ILAYLY...DLYvscshlrskfgdLFSSACSKVKQTIYSNvqpSNSNLLWdpefmldfienpSAH.SIN....YSMLGKILSDNAANRYSFVCNSLMN..VCM.GHQDAGRINDIANLCAELTACCTMLS......SEWLG.VLKALC
 1103- 1285 (211.48/140.04)	LLCSVDVSDlSFHDSLATFIAILIAR.............QCF.SLEDVVQHVALPSllaaACGDPDaepgarmTCrLLLHLFrtpQVY............LFSQATGKSFPGIRSS...CDRHLLT............AAHnSIEvgavFAVLKAILMLGDAEIGSSSINSLKNedFSMrGLLDDLDDDEIWGASHTLTSCGKAISietaslSEYARyVLRTIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.02|      50|     202|    1386|    1438|       3
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 1386- 1438 (69.23/61.60)	LLDNIAKATIEvFQQSADLNNNSSNSgIGLFnPNSVGNADTSNTRQNG....KKTFL
 1582- 1635 (75.79/51.78)	LLQIITSGTVD.MQTNNELFTTVLDM.LGVL.INGTLASDLSNASQGGseenKRAYM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.98|      30|     202|     222|     260|       4
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  231-  260 (52.44/28.30)	EYNEKL.AFYMFQEGMLERHEYLTWILDVLE
 1539- 1569 (46.54/44.03)	RYQDDVkARQMMHEALQLRLNLVGGMFDTVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.98|      36|      36|    1687|    1722|      12
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 1651- 1685 (31.24/15.44)	...ES..IDKVRQLLPLPKQTCDiitcePMgSLIDTKGN....K
 1687- 1722 (63.59/40.15)	AGFDS..IDKKQGLQVSTKQKVS.....PW.DLFEGHKNPAPLS
 1724- 1757 (51.15/30.65)	AWFGTvrVDRKV.IKYEEQQHLL.........LYHMHPKPKPRS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06888 with Med12 domain of Kingdom Metazoa
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