<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06877

Description Mediator of RNA polymerase II transcription subunit 25 isoform A
SequenceMVVPGPEAAALGGPGGMVADVVFVIEGTANLGPYFESLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDSIQFVGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHKVCILICNSPPYLLPAVESTTYSGYTTENLVQKIGERGIHFSIVSPRKLPALRMLFEKAVPAGMMEAQPKDYSQDPRHMILIRGMALPVGGSAASNTIQPKQVVPQPQLPTAPPQLPPAPPQPLPSASQSYQVTPTNSLNAAQAAAQSAVEAAKNQKAGITRFPMPTAFTQGPAQPLPAGSVPPMAPKMPPSSQPSLVSTVTSSSGLLPQPPGQPPPQPSAPTMPSSVAPSGVSVAQPAASQIGAAQLPGAQQTVASKVVAWSGVLEWQEKPKPASVDSSTKLTRSLPCQVFVNPGENLKTDQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFNFTNKDLESLKGLYRIMGNGFAGCVHFPHTTPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKIEQQRSQLGSSQPLGSAPVPNTQPFLPKQPGALPVAQGVQQQVRMGGILLNVWWWGGGC
Length612
PositionUnknown
OrganismAlligator mississippiensis (American alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.07
Grand average of hydropathy-0.150
Instability index54.39
Isoelectric point8.81
Molecular weight65357.36
Publications
PubMed=22293439

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06877
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.48|      29|      36|     313|     341|       1
---------------------------------------------------------------------------
  314-  352 (49.69/15.14)	GPAQPLPAGSVPPMAPKMPPSSQPSLVStvtsssgllpQ
  353-  379 (40.76/11.25)	PPGQPPP....QPSAPTMPSSVAPSGVS........vaQ
  562-  583 (30.03/ 6.57)	GSSQPLGSAPVPNTQPFLP..KQP...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.69|      50|      72|      79|     129|       2
---------------------------------------------------------------------------
   79-  129 (85.76/60.22)	CAPESYVqCHAPTSSAYEFVTWLDSIQFVGGGGESCSLIAEGLSTALQ.LFD
  149-  199 (83.93/54.29)	CNSPPYL.LPAVESTTYSGYTTENLVQKIGERGIHFSIVSPRKLPALRmLFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.94|      41|      74|     430|     474|       3
---------------------------------------------------------------------------
  430-  474 (62.63/60.09)	PCQVFVnpGENLKTDQwpQKLIMQLIPQQ...LLTTLGPLFRNSRMVQ
  507-  550 (67.32/47.11)	PCEVRV..LMLLYSSK..KKIFMGLIPYDqsgFVNGIRQVITNHKQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.72|       9|     195|     297|     309|       5
---------------------------------------------------------------------------
  270-  278 (16.82/ 6.73)	SQSYQVT....PT
  297-  309 (10.90/14.18)	NQKAGITrfpmPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.76|      13|      30|     201|     213|       7
---------------------------------------------------------------------------
  201-  213 (25.55/12.04)	AVPAGMMEA....QPKD
  228-  244 (18.21/ 6.71)	ALPVGGSAAsntiQPKQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06877 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SAASNTIQPKQVVPQPQLPTAPPQLPPAPPQPLPSASQSYQVTPTNSLNAAQAAAQSAVEAAKNQKAGITRFPMPTAFTQGPAQPLPAGSVPPMAPKMPPSSQPSLVSTVTSSSGLLPQPPGQPPPQPSAPTMPSSVAPSGVSVA
234
378










Molecular Recognition Features






MoRF SequenceStartStop




NANANA