Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MATHAVANERLRALEELEREIGASLQSAGNVILELSKEKANERALERQAAQFSAAVQKVEAELSAQIRYLTQVATGQPHEGSSYSAGKDCQLALNRVDYARLKLGELARTCEQMLEP |
Length | 117 |
Position | Head |
Organism | Alligator mississippiensis (American alligator) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.415 |
Instability index | 25.26 |
Isoelectric point | 5.44 |
Molecular weight | 12840.33 |
Publications | PubMed=22293439 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06872 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.58| 25| 30| 7| 36| 1 --------------------------------------------------------------------------- 7- 36 (31.24/35.18) ANErlRALEELEREIGASLQsagNVILELS 40- 64 (41.34/27.89) ANE..RALERQAAQFSAAVQ...KVEAELS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FSAAVQKVEAELSAQIRYLTQVATGQPHEGSSYSAGKDCQL 2) LEREIG 3) NVILELSKEKANERALERQAA | 52 17 30 | 92 22 50 |
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