<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06870

Description Cyclin-dependent kinase 8 isoform B
SequenceMDYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKNQQQQQGNNHTNGTGHPGNQDNSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSTTSQQPPQYSHQTHRASFGDHRNPGIGVRQFDLSMFSSPDICKCYECQEISGSGKSNQNTFYKFRNAARPKRLRLGELLEGLSRELEMEEVIKKLLDQE
Length546
PositionKinase
OrganismAlligator mississippiensis (American alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.09
Grand average of hydropathy-0.704
Instability index39.37
Isoelectric point8.49
Molecular weight62628.56
Publications
PubMed=22293439

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06870
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.00|      26|      35|     422|     447|       1
---------------------------------------------------------------------------
  376-  416 (28.52/16.21)	QGNN.HTNG....TGHPGnqdNSHTQgpPlkkvrvvpptTTSGGLI
  422-  447 (51.04/35.50)	QRSN.PHAA....YPNPG...PSTSQ..P..........QSSMGYS
  455-  484 (35.44/22.14)	QYSHqTHRAsfgdHRNPG...IGVRQ..F..........DLSM.FS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.32|      54|      87|     209|     265|       2
---------------------------------------------------------------------------
  209-  265 (87.19/62.72)	RHYTKAiDIWAIGcIFAELLTSEPIFHCRQEDiKTSNPYH.HDQL..DRIFNVMGFPADK
  299-  355 (89.13/51.25)	KHKVKP.DSKAFH.LLQKLLTMDPIKRITSEQ.AMQDPYFlEDPLptSDVFAGCQIPYPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      35|     151|     165|       3
---------------------------------------------------------------------------
  151-  165 (26.77/18.59)	DLKPANILVMGEGPE
  189-  203 (28.67/20.41)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06870 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLTEEEPDDKGDKNQQQQQGNNHTNGTGHPGNQDNSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSTTSQQPPQYSHQTHRASFGDHRNPGIGVRQ
351
477










Molecular Recognition Features






MoRF SequenceStartStop




1) NTFYKFRNAARPK
506
518