<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06866
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MAAAAGGERSSTRDRLLAALEDLELLARELIEILAISRNQKLPQPGEESQILELLIQRDGEFQELMKLALDQGKIHHEMQLLEKVVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIEKARKGAISSEEIIKYSHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGWLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSSDMSINMLPPNHSSDFMLEPPGHNKENEDDVEVMSTDSSSSSSDSD |
Length | 256 |
Position | Middle |
Organism | Alligator mississippiensis (American alligator) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae>
Alligator.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.590 |
Instability index | 57.36 |
Isoelectric point | 4.97 |
Molecular weight | 28368.60 |
Publications | PubMed=22293439
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP06866
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.82| 23| 23| 202| 224| 2
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202- 224 (43.07/23.99) LAPQYPWQSSDMSINMLPPNHSS
228- 250 (38.75/21.00) LEPPGHNKENEDDVEVMSTDSSS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.47| 20| 27| 87| 107| 3
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87- 107 (27.91/25.19) EKRDSdIQQLQKQLKEAEHIL
116- 135 (30.56/21.65) EKLKS.IEKARKGAISSEEII
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