<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06853

Description XK-related protein
SequenceMHNINRERSNVTWIALALQAVWRSSMLISRFIVLVLALIFLKVWFFLFLGLHWFIMTIWVILQKTKFCSTAWEERIYNCVIGLIYCFDFFNLRDDRSRYRVLIFYSVIAAQNVIFLIIYMLHAGETIAMIMIASVIVSCMLIGLTSMSLYYGKFHPSRTATNISRNISEHSTTTKVEASRSFKLFHRDSLVSLHHSMDISPRTEEVPTDKQSLLTNIAQISDCVEEGIVNRNYSSENEFNASALRLSTECERPHSRVGVKHKEEATSVNDNNPDNALTSSAPLNSLYSGLPDIDSSRKRRGIYEHDITPQLDWHAPDILNIDLDQLGNLDNSERSNSLTLDSCSKVIGALDVIKNREKLTTPTPLESNRIFDIEKQRDETMSCVTSIHDYENVCPLGIARPPWCIRSWKGYTDIETYIHDDSVVRDRRRDTLTSTTGTTYSSEYSDGMISRGILKQDDYADALTYDLVESKGNKSSYSDSTFSTSTDDQNASLYIAKPVVFDDRGGMLALDTILEERDDLSSSDEKFQHGSELSRDSASTLVSTIDQIRRYTAENSPRHIYHTTGTHWEDLNPKNLMAQAHFAKVLFDNDLRNASTTTGSIDLTARDVEKREIDAIREFVRCCAIESIKKTPLIDAVLSDSPILDKASKLMRQVTFADCKNDFDTNESDLYVEMSPLVSVENGENLCQARSIDAKTGEAESDTLKRNTLPTISEKSPNKENLSPSLSNNNRRINNIYDDRDNNDSHAWTIERDEKNDKSLCNMRFNLKEKRHLFLEQVLSPVPKLWNKPGQPSPGGGSASDKGKEWQMEFLMEKLRSKSSTYKPLVETAKNMRMAMLDKRFAIDSIEKNQLQKCLDTLQHSIKVTSFQSMVERLESLARQLGLKFMMSGSPGTEIFISSDMFFLEVLLEPPSGLVRDVKIHHEGKSEQQSCEALASALSRGDFVDFTTQLEGLASIYQLNADKKVKCKAFSALQSLEADLGVLAQLQTFMKEPFNLVHKSPVGILERRRGGHPMKLTYFVSPYDLIDEENRTYDTLNSDTIIKRKIGHSVTVCMEGSTGHKLPTSSIITVNRSPTGKSTPSYAPLTSTNSSMLPACFVLKLVKKMPICMELVKRIQKVTELECGDISAPHPLLSLIIQHASDGQLDCRNNRGLYVTLPDQQHCYFMTENKNMEGVLVCSIPFTHPAHVPQILVYLRQQALFNCLIASCVRPMARQDPEHTTILEVSALSWQHISVSVEHPYEETMATAELDLTDISTLKCRLYGMSMTTNVEQTSDLSGRVLQRCLSIPLTMRMLLKIWEGRSLPAVMNSLTSGSGSSNGSYNLNLGSGANSTSTSMLNPLQLGALLGQAKNSVTSNSNTNERGKKTRKRKTGTDGLWRSPKRKSDGGDSSAATEILLESSSSENSTPLGTPTSRENLASETRTSTPTSATSLTSGMDFSNLDTTDILDKSASDYDLDNSEKDSEIMEVQHSAEQQQQQQQQPQQEVEELIKIRESSSTRKSKKNRSGGGSEEKKSSPTNIFVDETSTTNSGNKSLPVPPSVSITPISCGNLDQASTTNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPTPSPKTSGLTSATEDRQRSERKSGGGKSSGSSSKSSSEDTKSGGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGSAGVGLSCSSSRPTSPAAVKKFSPSPTHSSSLATLVGKSSPTLKAGQSAAATCSKSVQSPKHSPVYGSTVSVPVPVPASASPKHGNTSSPKHGSSAASSGKPSMSALKSAANSPSSKSSSSSSSDSATTPSKVKSSSSSSSNKDSSGRGDKDRRTSSISSSGGSGSGHQSPKTKSSSGKMKQLEMISPGSETTQVSLQASGGSTPPSGQIDAASKSAIAAQQARNRKSSLNAVIDKLKNAQHCTETDACGNGGGNVKGSGSSGLGSTGGMSSAGQKEKNIGSGGGSSSSGGKAIGEGGKSCVTKNASVDTKNPGEYMVKHSSDGIKITINKTRTKDSKQAANLKLSSSGSMAATSSSSSLSSVASSSSSSSSNVTTGSNGSPKTHTGLKPGVNSGPASKKPQTLQAAQKMLPTKMMLAASGMKSAISSSSTTNTGSSAGITASATGGVAGNPLSKSSSSKASGSPKTSSGVTDLSRGRDKPRISKSGDKGIFASKGLGDARKSSPSALREESESERAFKLLAAHASISNLPPSLPPQLMMEGLMKQLDTKFQIPKLSARANVADADKNKSSDKLSILSDSKQTLDGLKQEQGKIAGLSNVTVSVSKSSQPDDQSRRDHSQTKPDNLSITTSAAGAMSLNLVGENTGLMLPSQSTADSDVPTNLCIQPMVDNEPSRDSCKDLGIRQTSTGQQFLGKIDDTSVGGILSKSNVSDQLTSSGAKSYGTLTSSNTSTTPSGAIVTESLNLSTKPADQAILQTKYNKITAEEKKQQQTSSASLSSSSSSSSSSSSSIFSSLASAATSSDAAAEMLLDFSAANKDTMTKGGHGLPASLTQHHLTIPERAMTQAAPTVRRNTPPPPPPPPPLPAPFPPAASPSVSVHIVKSPAPSPRVIPPSPHSSASPCITDDELMDEALVGMGK
Length2616
PositionMiddle
OrganismTrachymyrmex septentrionalis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.04
Grand average of hydropathy-0.507
Instability index55.19
Isoelectric point8.65
Molecular weight280959.81
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-UniRule
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06853
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.98|      11|      15|    1573|    1584|       2
---------------------------------------------------------------------------
 1573- 1584 (17.77/11.77)	P.GIEIIPIAsSP
 1590- 1601 (19.20/ 7.96)	PsSITITPIA.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1020.43|     220|     239|    1862|    2095|       8
---------------------------------------------------------------------------
 1325- 1550 (215.33/67.83)	.NLGSGA....NSTSTSmlnplqlGALLGQ..AKNSVTSNS.....NTNE.......RGK......KTRKRKTGTD.GLWRSPKRKSDGGDSSAATeillESS.......................SSENSTPLGTPTSRENLASETrTS.....................TPTSATSLTSGMDFSNldttdildK............................................................................................................................SASDYDLDNSEKDSEIME....VQHSAEQQQQQQQ..........QPQQEVEElikiressstrKS.KKNRSGGGSEEKKSSpTNIFVD.E......TS...............TTNSGNKSLPV..PPSVSitpiscG.
 1622- 1737 (72.81/18.30)	............RKSGG.......GKSSGSS.SKS.....SSEDTKSGGSKLEKR...............RKRKRE.DGPMGPPDKVPSGGKQQQD....PLS.......................KPV.SVSIKPSTEQSPPSGGS.AGvglscsssrptspaavkkfspSPTHSSSLATLV..GK........S........................................................................................................................................................................................................................................................................
 1862- 1961 (110.42/31.37)	....................................................................................................................................................................................................sptlkagqsaaatcsksvqspkhspvygstvsvpvpvpasaspkhgntsspkhgssaassgkpsmsalksaanspssksssssssdsattpskvksssssssnkdssgrgdkdrrtssisssggSGSGHQSPKTKSSSGKMKQLEMISPGSETTQVSLQASGGST....PPSGQIDA...........AS.KSAIAAQQARNRKSS.LNAVIDKLKNAQHCTE...............TDACGNGGGNV..KGSGS......SG
 1976- 2159 (272.77/88.49)	KNIGSGG....GSSSSG.......GKAIGEG.GKSCVTKNASVDTKNPGEYMVKHSSDGI......KITINKTRTK.DSKQAANLKLSSSGSMAAT....SSS.......................SSLSSVASSSSSSSSNVTTGS.NG.....................SPKTHTGLKPGVNSG..............................................................................................................................................................PASKKPQ.TLQAAQKML....PTKMMLAA...........SGmKSAISSSSTTNTGSS...AGI..........T...............ASATGGVAGNPlsKSSSS......KA
 2160- 2409 (205.21/64.31)	....SGS....PKTSSG.......VTDLSRGrDKPRISKSG.....DKGIFASKGLGDAR......KSSPSALREEsESERAFKL.LAAHASISNL....PPSlppqlmmeglmkqldtkfqipklSARANVADADKNKSSDKLSIL.SD.....................SKQTLDGLKQ..EQGK.......iA................................................................................................................glsnvtvsvsksSQPDDQSRRDHSQT.KPDNLSI..TTSAAGAMSLNLVGENTglmlPSQSTADS...........DV.PTNLCIQ...........PMVDNEPSRDSCKDlgirqtstgqqflgkIDDTSVGGILS..KSNVS........
 2410- 2555 (143.89/41.61)	DQLTSSGaksyGTLTSS.......NTSTTPS.G.AIVTESLNLSTK.PAD.......QAIlqtkynKITAEE...K.KQQQTSSASLSSSSSSSSS....SSS.......................SIFSSLASAATSSDAAAEMLL.DF.....................SAA.........NKDT........M............................................................................................................................TKGGHGLPAS......LTQHHLTIPERAMTQAAPTVRRNTP....PP.............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     617.52|     198|     223|     579|     792|       9
---------------------------------------------------------------------------
  461-  567 (63.38/26.68)	...............................................................................................................................................DALTYDLVESKGNKSSYSDStFSTSTDDQNASLyiakPVVFD.DRGGM.LALDTILE..ERDDLS.SSDEKFqhgselsrdsastlvsTIDQIRRYTAEN..SP.RHI.YHTTGTH
  579-  792 (303.13/211.88)	QAHFakvLFDNdLRNASTTTGSIDLTARDVEKREIDaiREFvrccAIESIKKTPL...IDA......VLSDSPILDKASKLMRQVTFADCKNDFDTNE....SDlyveMSPL.VSVENGENLCQARSI......DAKTGEAESDTLKRNTLPTISEKSPNKEN.LSPSLSNNNRRI....NNIYD.DRDNN.DSHAWTIERDEKNDKS.LCNMRF................NLKEKRHLFLEQvlSPVPKL.WNKPGQP
  807- 1013 (251.01/143.81)	QMEF...LMEK.LRSKSSTYKPLVETAKNMRMAMLD..KRF....AIDSIEKNQLqkcLDTlqhsikVTSFQSMVERLESLARQLGLKFMMSGSPGTEifisSD....MFFLeVLLEPPSGLVRDVKIhhegksEQQSCEALASALSRGDFVDFTTQ...LEG.LAS...............IYQlNADKKvKCKAFSALQSLEADLGvLAQLQT................FMKEPFNLVHK...SPVGILeRRRGGHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     265.63|      84|     105|    1093|    1183|      12
---------------------------------------------------------------------------
 1093- 1183 (139.17/121.58)	LPACFVLKLVKKMPicmelVKRIQKVTELECGDISAPHplLSLIIQH.....ASDGQLDCRNNRGLYVTLPDQQHCYFMTENKNMEG.VL.VC.SIPFT
 1200- 1291 (126.46/91.45)	LFNCLIASCVRPMA.....RQDPEHTTILEVSALSWQH..ISVSVEHpyeetMATAELDLTDISTLKCRLYGMSMTTNVEQTSDLSGrVLqRClSIPLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.37|      19|      24|    2556|    2574|      13
---------------------------------------------------------------------------
 2556- 2574 (41.00/17.91)	PPPPPPLPAPFP.PAASPSV
 2582- 2601 (34.37/13.79)	PAPSPRVIPPSPhSSASPCI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.15|      12|    1016|     793|     804|      16
---------------------------------------------------------------------------
  793-  804 (23.50/ 9.95)	SP.GGGSASDKGK
 1787- 1799 (18.66/ 6.17)	SPkHGSSAASSGK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06853 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEMLLDFSAANKDTMTKGGHGLPASLTQHHLTIPERAMTQAAPTVRRNTPPPPPPPPPLPAPFPPAASPSVSVHIVKSPAPSPRVIPPSPHSSASPCITDDELMDEALVGMGK
2) AGLSNVTVSVSKSSQPDDQSRRDHSQTKPDNLSITTSAAG
3) CERPHSRVGVKHKEEATSVNDNNPDNALTSSAPL
4) GEAESDTLKRNTLPTISEKSPNKENLSPSLSNNNRRINNIYDDRDNNDSHAWTIERD
5) ILQTKYNKITAEEKKQQQTSSASLSSSSSS
6) MLNPLQLGALLGQAKNSVTSNSNTNERGKKTRKRKTGTDGLWRSPKRKSDGGDSSAATEILLESSSSENSTPLGTPTSRENLASETRTSTPTSATSLTSGMDFSNLDTTDILDKSASDYDLDNSEKDSEIMEVQHSAEQQQQQQQQPQQEVEELIKIRESSSTRKSKKNRSGGGSEEKKSSPTNIFVDETSTTNSGNKSLPVPPSVSITPISCGNLDQASTTNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPTPSPKTSGLTSATEDRQRSERKSGGGKSSGSSSKSSSEDTKSGGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGSAGVGLSCSSSRPTSPAAVKKFSPSPTHSSSLATLVGKSSPTLKAGQSAAATCSKSVQSPKHSPVYGSTVSVPVPVPASASPKHGNTSSPKHGSSAASSGKPSMSALKSAANSPSSKSSSSSSSDSATTPSKVKSSSSSSSNKDSSGRGDKDRRTSSISSSGGSGSGHQSPKTKSSSGKMKQLEMISPGSETTQVSLQASGGSTPPSGQIDAASKSAIAAQQARNRKSSLNAVIDKL
7) NLVGENTGLMLPSQSTADSDVPTNLCIQPMVDNEPSRDSCKDLGIR
8) PKLSARANVADADKNKSSDKLSILSDSKQTLDGLKQEQG
9) QHCTETDACGNGGGNVKGSGSSGLGSTGGMSSAGQKEKNIGSGGGSSSSGGKAIGEGGKSCVTKNASVDTKNPGEYMVKHSSDGIKITINKTRTKDSKQAANLKLSSSGSMAATSSSSSLSSVASSSSSSSSNVTTGSNGSPKTHTGLKPGVNSGPASKKPQTLQAAQKMLPTKMMLAASGMKSAISSSSTTNTGSSAGITASATGGVAGNPLSKSSSSKASGSPKTSSGVTDLSRGRDKPRISKSGDKGIFASKGLGDARKSSPSALREESESE
2504
2293
250
697
2452
1337
2337
2252
1939
2616
2332
283
753
2481
1935
2382
2290
2213










Molecular Recognition Features






MoRF SequenceStartStop




1) KMKQLEMI
2) RAFKLL
3) TLQAAQKMLPTKMM
1877
2214
2101
1884
2219
2114