<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06849

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPVTNNIPQEGNRGGSISLGMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLYVRLLALVKWANSASKVDKSTNIIKTYSLIICSFQHIMAFLDKQSLLFVDTADMLARMARDTLVHARLPNFHIPAAVEVLTTGTYGRLPACIRERIVPPDPITPTEKRSTLQRLNQVIQHRLVTGNVLPQMRNLKIEAGRVTFLIEQEFSVSLTVMGDGPTVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVVQSRLAESTNPLSEVYHILHYFCQSLQLEVLYSQTELTRKDPRSELGYRLTVQVDQHDPARPLAVVHIPSLGSKESEIAHRAIRSDQLSMECLLVHTIYVRTRSRTLAGSPAILSVPILQPCLRAELLLVTVDTHTGMLQCHVPQYDAPLVPELTLALNGDHSRLPTLISELRFWITQRRCEKTLQHLPATSHERLPIVAFKEKESSPCEIECSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDSGNNDQDGGCITEVVETSNNKRRSTGVGGRTDAVGTPQNRRPKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLKLVQLPAPSPSIATSCAWHALLKRLLSVSIRVQGKGMAKTWTVEFVFYGSPLSSSHPKEQGLRRPVYFQYEMGTADTVSRTVDVLLNDWAQIVHLYLIVHDLAEYFKMEKYNFRNMVSIKSYSYSKLVLAYGPNQGATVTIQWSTNDKVFKLVFGPTNTVTNAHSIMKEQLEAHLNRYTNLAQIIHILNETLQPLTSISKLPSIPQLCVHARPRVPVQTFTIMPQCVTLVRIAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDENAVYRRRSQSEDDNPPSPVTMDSDSAGGNVSFLGHHRSGPQSPAQQREGLRFHPPLTPPSASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPASQSMASPAASNWPGSPSVPRPSPARPGQNPGHAALHSPQASDHKTGSHISRVLPQRSWAGAVPTLLTHEALEMLCCPSSHPSALPGPDMSPLERFLGCVYMRRQLQRFIQTEDCVSKLVYKSVGLNPTHFQSLHIKVLSLPEYKDQWSVEELQIIEKFFDTRVAAPPYKHNTLSGFGRMLNVRFKVLKDFVQVMKLDLVPSLVQQQQLKWSVQLCLRIPPSAGPIVPPGTEGVHVCRSKILFFLQITRLGISYQGETPSLVLPFVHDVNTNITQLADRRDLTPPPSAIAAASMQLKRFAEYGANQSECSLFPAVRDLLANFTLPSEPPVISQVVPSAAGTQVASAQQIQNTAMQMHSPMAAGQGPPQGPGPYGIQGMQPMGMMGGPPQ
Length1435
PositionTail
OrganismTrachymyrmex cornetzi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.07
Grand average of hydropathy-0.196
Instability index55.87
Isoelectric point8.56
Molecular weight158897.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06849
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     181.11|      28|      38|     927|     954|       1
---------------------------------------------------------------------------
  927-  954 (51.47/24.94)	P.....P.SPVT.MDSDSAG..GNVSFLGH...HRS........GPQS
  966- 1002 (38.17/16.25)	P.....PlTPPS.ASPPSLP..PNTPNMLP...HPSpgsglvanSPLN
 1003- 1035 (33.22/13.02)	P..mhvP.SPAGlMPTSSPGpcSNVQ.VGH...SPA........GSFM
 1044- 1072 (32.50/12.55)	P....fP.ASQS.MASPAAS..N...WPGSpsvPRP........SPAR
 1077- 1104 (25.75/ 8.14)	PghaalH.SPQA.SDHKT.G..SHISRVLP...QRS............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     279.89|      75|      77|     184|     260|       2
---------------------------------------------------------------------------
  124-  185 (84.29/51.70)	............TADMLARMaRDTLVHARLPNFHIPA..AVEVLTTGTYGRL....P.....ACIRE.RIVPPDPITPTEKR..S.TLQ
  186-  262 (119.21/82.79)	RLNQVIQHRLV.TGNVLPQM.RNLKIEAGRVTFLIEQefSVSLTVMGDGPTV....P.....WRLLELEILVSDRETGDGKALVH.PLQ
  265-  338 (76.40/46.08)	YVHQVVQSRLAeSTNPLSEV.YHI......LHYFCQ...SLQLEVLYSQTELtrkdPrselgYR...LTVQVDQHDPARPLAVVHiP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.82|      27|     134|    1109|    1157|       5
---------------------------------------------------------------------------
 1109- 1135 (52.78/52.54)	VPTLLTHEALE...MLCC...PSSHPSALPGPD
 1246- 1278 (40.04/ 9.32)	VPSLVQQQQLKwsvQLCLripPSAGPIVPPGTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.03|      36|     872|     420|     488|       6
---------------------------------------------------------------------------
  410-  461 (53.13/64.00)	CHVP.QYDAPLV..................PELTLalngdhsRLPTLISELRFWITqrrcektlqHLPATS
  478-  532 (49.90/47.42)	CEIEcSFYLAVVkhssieddphddsieteiPKMYL.......KVQSLIEFDTFVIT.........HGPFTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.47|      21|      47|    1309|    1334|       7
---------------------------------------------------------------------------
 1309- 1334 (34.61/29.07)	LPFVHDVNTNITQLADrrdltPP......PSA
 1358- 1384 (33.86/17.37)	FPAVRDLLANFTLPSE.....PPvisqvvPSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.29|      15|      16|     821|     836|       8
---------------------------------------------------------------------------
  821-  836 (22.98/17.81)	PLTSISKLPSIPQlCV
  840-  854 (29.31/18.19)	PRVPVQTFTIMPQ.CV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.42|      34|      47|    1153|    1199|       9
---------------------------------------------------------------------------
 1153- 1199 (39.85/62.12)	QRFIQTEdcVSKLVYK.....SVG..LNpTHFqslhiKVLslpeyKDQWSVEEL
 1203- 1243 (51.57/33.05)	EKFFDTR..VAAPPYKhntlsGFGrmLN.VRF.....KVL.....KDFVQVMKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06849 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DGGCITEVVETSNNKRRSTGVGGRTDAVGTPQNR
2) QVASAQQIQNTAMQMHSPMAAGQGPPQGPGPYGIQGMQPMGMMGGPPQ
3) VYRRRSQSEDDNPPSPVTMDSDSAGGNVSFLGHHRSGPQSPAQQREGLRFHPPLTPPSASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPASQSMASPAASNWPGSPSVPRPSPARPGQNPGHAALHSPQASDHKTGSHISRVL
541
1388
915
574
1435
1100










Molecular Recognition Features






MoRF SequenceStartStop




NANANA