<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06846

Description XK-related protein
SequenceMHNINRERSDVTWVALVLQAVWRSGMLISRFMVLVLALIFLKAWFFLFLGLHWFIMTIWVILQKTKFCSTAWEERIYNCVIGLIYCFDFFNLRDDRSRYRVLIFYSVIAAQNVVFLIIYMLHVGETIAMIMIASVIVSCMLIGLTSMSLYYGKFHPSRTATNISRNISEHSTTTKVDASRSFKLFHRDSLVSLHHSMDISPRTEEVPTDKQSLLTNIAQISDCVEEGIVNRNYSSENEFNASALRLSTECERPHSRVGVKHKEEVTSVNDNPDNTLTSSAPLNSLYSGLPDIDSSRKRRGIYEHDITPQLDWHAPDILNIDLDQLGSIDNSEGSNSLTLDSCSKVIGALDVIKNREKLTTPTPLESSRIFDIEKQRDETMSCVTSIHDYENVCPLGIARPPWCIRSWKGYTDIETYIHDDSVVRDRRRDTLTSTTGTTYSSEYSDGMISRGILKQDDYADALTYDLVESKGNKSSYSDSTFSTSADDQNASLYIAKPVVFDDRGGMLALDTILEERDDLSSSDEKFQHESELSRDSASTLVSTIDQIRRYTAENSPRHIYHTTGTHWEDLNPKNLMAQARFAKVLFDNDLRNASTTTGSIDLTARDVEKREIDAIREFVRCCAIESIKKTPLIDAVLSDSPILDKASKLMRQVTFADCKNDFDTNESDLYVEMSPLVSVENGESLCQARPIDAKTTEAESDTLKRNTLPIISEKSPNKENLSPSLSNNNRRINNIYDDGDNNDSHAWTIERDEKNDKSLCNMRFNLKEKRHLFLEQVLSPVPKLWNKLGQPSPGGGSASDKGKEWQMEFLMEKLRSKSSTYKPLVETAKNMRMAMLDKRFAIDSIEKNQLQKCLDTLQHSIKVTSFQSMVERLESLARQLGLKFMMSGPPGTEIFISSDMFFLEVLLEPPSGLVRDVKIHHEGKSEQQSCEALASALSRGDFVDFTTQLEGLASIYQLNADKKVKCKAFSALQSLEADLGVLAQLQTFMKEPFNLVHKSPVGILERRRGGHPMKLTYFVSPYDLIDEENRTYDTLNPDTIIKRKIGHSVTVCMEGSTGHKLPTSSIITVNRSPTGKSTPSYAPLTSTNSSMLPACFVLKLVKKMPICMELVKRIQKVTELECGDISAPHPLLSLIIQHASDGQLDCRNNRGLYVTLPDQQHCYFMTENKNMEGVLVCSIPFTHPAHVPQILVYLRQQALFNCLIASCVRPMARQDPEHTTILEVSALSWQHISVSVEHPYEETMATAELDLTDISTLKCRLYGMSMTTNVEQTSDLSGRVLQRCLSIPLTMRMLLKIWEGRSLPAVMNSLTSGSGSSNGSYNLNLGSGANSTSASMLNPLQLGALLGQAKNSLTSNSNTNERGKKTRKRKIGTDGLWRSPKRKSDGGDSSAATEILLESSSSENSTPLGTPTSRENLASETRTSTPTSATSLTSGMDFSNLDTTDILDKSASDYDLDNSEKDSEIMEVQHSNAEQQQQQQQQQPQQEVEELIKIRESSSTRKSKKNRSGGGSEEKKSSPTNIFVDETSSSGNKGLPVPPSVSITPISCGNLDQASTTNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPTSSPKTSGLTSATEDRQRSERKSGGKSSGSSSKSSSEDTKSGGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGNAGVGLSCSSSRPTSPAAVRKFSPSPTHSSSLATLVGKSSPTLKAGQSAAATGKPVQSPKHSPVYGSTVSVPVPVPASASPKHGNTSSPKHGSSAASSGKPSMSALKSAANSPSSKSSSSSSSDSATTPSKVKSSSSSSSKDSSGRGDKDRRTSSVSSSGGSGSGHQSPKTKSSSGKMKQLEMISPGSEATQVSSLQASGGSTPPSGPVDAASKSAIAAQQARNRKSSLNAVIDKLKNAQHCTETDACGNGGGNMKGSGSSGLGSTGGMSSAGQKEKNIGGGGSSSSSGGKTIGEGGKSCVTKNASVDTKNPGEYMVKHSSDGIKITINKTRTKDSKQAANLKLSSSGSMAATSSSSSLSSVASSSSSSSSSNVITGSNGSPKTHTGLKPGVNSGPASKKPQTLQAAQKMLPTKMMLAAAGMKSAISSSGATNTGGGGGITASATGGVGGNPLSKSSSSSKASGSPKTSSGVTDLSRGRDKPRISKSGDKGIFASKGLGDARKSSPSALREESESERAFKLLAAHASISNLPPSLPPQLMMEGLMKQLDTKFQIPKLSARANIADADKNKSSDKLSILPDSTKQTLDGLKQEQGKIAGLSNVTVSVSKSSQPDDQSRRDHSQNKPDNLSITTSAAGAMSLNLVGENTGLMLPPQSTADSDVPTNLCIQPMVDNEPSRDSCKDLGMRQTSTGQQFLGKIDDTSVGGILSKSNVSDQLTSSGAKSYGTMTSSSTSTASSGAIVAESLNLSTKSADQAVLQTKYNKITVEEKKQQQTSSASLLSSSSSSSSSSASIFSSLASVATSSDGNPVMTSDSGGGGGGGGGHGLPASLTQHHLTTIPERAMTQAAPTVRRNTPPPPPPPPPLPAPFPPAASPSVSVHIVKSPAPSPRVIPPSPHSSASPCITDDELMDEALVGMGK
Length2614
PositionMiddle
OrganismTrachymyrmex cornetzi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.04
Grand average of hydropathy-0.493
Instability index56.20
Isoelectric point8.58
Molecular weight280083.03
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-UniRule
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06846
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.75|      11|      16|    1572|    1583|       8
---------------------------------------------------------------------------
 1572- 1583 (17.66/14.06)	P.GIEIIPIAsSP
 1589- 1600 (19.09/ 9.52)	PsSITITPIA.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     445.55|     111|     122|    1299|    1413|       9
---------------------------------------------------------------------------
 1299- 1374 (99.09/37.41)	...................................................EG...R.SLPAVMNSLTSGSGSSNGSYNLNLG......SGA......NSTSASMLNP....LQLGALLGQAKNSLTSNSNTNERGK....K.......TRKRKIGTD
 1379- 1502 (128.68/55.51)	SPKRKSDGGD...SSAATEILL.ESSSSEN.STPLG.....TPTSrenlasET...RtSTPTSATSLTSGMDFSNLDTTDILD......KSAsdydldNSEKDSEIME....VQHSNAEQQQQQQQQQPQQEVEELI....K.iresssTRK......
 1503- 1567 (40.08/ 8.02)	SKKNRSGGGSeekKSSPTNIFVdETSSSGNkGLPVPpsvsiTPIS......CGnldQ.ASTTNYNSVLTGMG......................................................................................
 1847- 1926 (79.72/28.38)	........................................................R.RTSSVSSS..GGSGSGHQSPKTK.S......SSG......KMKQLEMISPgseaTQVSSL..QASGGSTPPSGPVDAAS....KsaiaaqqARNRKSSLN
 2041- 2104 (63.36/20.75)	.....SSSGS....MAAT.....SSSSSLS.S...........VA......SS.....SSSSSSSNVIT..GS.NGSPKTHTGlkpgvnSGP......ASKKPQTLQA....AQ............................................
 2139- 2186 (34.60/ 7.33)	.................................................................SATGGVG...GNPLSKSS......SSS.....kASGSPKT.......................SSGVTD.LSrgrdK.......PRISKSGDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.00|      44|     117|     156|     199|      10
---------------------------------------------------------------------------
  156-  199 (75.06/46.34)	PSRTATNISRNISEHSTTTKVDASRSFK.LFHRDSLVSLH.HSMDI
  272-  317 (68.94/41.85)	PDNTLTSSAPLNSLYSGLPDIDSSRKRRgIYEHDITPQLDwHAPDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.89|      26|     117|    1011|    1038|      11
---------------------------------------------------------------------------
 1011- 1038 (42.37/37.83)	HPMkLTYFV...SPYDLIDEENR.TYDTLnPD
 1129- 1158 (39.52/25.08)	HPL.LSLIIqhaSDGQLDCRNNRgLYVTL.PD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     198.94|      45|     121|    2196|    2240|      12
---------------------------------------------------------------------------
 2196- 2240 (75.13/41.13)	DARKSSPSALREESESERAFKL.LAAHASISNLPP......SLPPQLMMEGL
 2245- 2262 (25.25/ 8.54)	DTKFQIP..............K.LSARANIAD...................A
 2263- 2285 (36.13/15.65)	DKNKSSD.............KL........SILPD......S..TKQTLDGL
 2315- 2366 (62.43/32.83)	DHSQNKPDNLSITTSAAGAMSLnLVGENTGLMLPPqstadsDVPTNLCIQPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.23|      16|     121|    1992|    2009|      13
---------------------------------------------------------------------------
 1992- 2007 (27.19/21.22)	GGKSCVTKNASVDTKN
 2019- 2034 (26.04/11.17)	GIKITINKTRTKDSKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.61|      41|     121|     421|     486|      17
---------------------------------------------------------------------------
  435-  482 (58.24/68.26)	TGTTYSSEYSDGMISrGILKQDDYADALTydlveSKGNKsSYSDSTFS
 2386- 2426 (71.38/28.45)	TGQQFLGKIDDTSVG.GILSKSNVSDQLT.....SSGAK.SYGTMTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.82|      15|      16|    1048|    1062|      22
---------------------------------------------------------------------------
 1048- 1062 (27.20/16.88)	SVTVCMEGSTGHKLP
 1065- 1079 (25.62/15.34)	SIITVNRSPTGKSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.28|      16|      16|    1768|    1783|      23
---------------------------------------------------------------------------
 1768- 1783 (29.76/17.83)	PVPVPASASPKHGNTS
 1785- 1800 (27.52/15.66)	PKHGSSAASSGKPSMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.09|      10|     533|    1976|    1985|      24
---------------------------------------------------------------------------
 1976- 1985 (19.60/ 6.30)	GGGGSSSSSG
 2512- 2521 (20.49/ 6.94)	GGGGGGGGHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.62|      10|      16|    1633|    1642|      27
---------------------------------------------------------------------------
 1633- 1642 (16.61/ 7.61)	KSSSEDTKSG
 1651- 1660 (19.01/ 9.98)	KRKREDGPMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.35|      19|      24|    2554|    2572|      31
---------------------------------------------------------------------------
 2554- 2572 (41.17/18.54)	PPPPPPLPAPFP.PAASPSV
 2580- 2599 (32.19/12.77)	PAPSPRVIPPSPhSSASPCI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06846 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGLSNVTVSVSKSSQPDDQSRRDHSQNKPDNLSITTSAAG
2) CERPHSRVGVKHKEEVTSVNDNPDNTLTSSAPLN
3) FSSLASVATSSDGNPVMTSDSGGGGGGGGGHGLPASLTQHHLTTIPERAMTQAAPTVRRNTPPPPPPPPPLPAPFPPAASPSVSVHIVKSPAPSPRVIPPSPHSSASPCITDDELMDEALVGMGK
4) GQAKNSLTSNSNTNERGKKTRKRKIGTDGLWRSPKRKSDGGDSSAATEILLESSSSENSTPLGTPTSRENLASETRTSTPTSATSLTSGMDFSNLDTTDILDKSASDYDLDNSEKDSEIMEVQHSNAEQQQQQQQQQPQQEVEELIKIRESSSTRKSKKNRSGGGSEEKKSSPTNIFVDETSSSGNKGLPVPPSVSITPISCGNLDQASTTNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPTSSPKTSGLTSATEDRQRSERKSGGKSSGSSSKSSSEDTKSGGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGNAGVGLSCSSSRPTSPAAVRKFSPSPTHSSSLATLVGKSSPTLKAGQSAAATGKPVQSPKHSPVYGSTVSVPVPVPASASPKHGNTSSPKHGSSAASSGKPSMSALKSAANSPSSKSSSSSSSDSATTPSKVKSSSSSSSKDSSGRGDKDRRTSSVSSSGGSGSGHQSPKTKSSSGKMKQLEMISPGSEATQVSSLQASGGSTPPSGPVDAASKSAIAAQQARNRKSSLNAVIDKL
5) NAQHCTETDACGNGGGNMKGSGSSGLGSTGGMSSAGQKEKNIGGGGSSSSSGGKTIGEGGKSCVTKNASVDTKNPGEYMVKHSSDGIKITINKTRTKDSKQAANLKLSSSGSMAATSSSSSLSSVASSSSSSSSSNVITGSNGSPKTHTGLKPGVNSGPASKKPQTLQAAQKMLPTKMMLAAAGMKSAISSSGATNTGGGGGITASATGGVGGNPLSKSSSSSKASGSPKTSSGVTDLSRGRDKPRISKSGDKGIFASKGLGDARKSSPSALREESESERAFKLLAAHASISNLPPSLPPQLMMEGLMKQL
6) NLVGENTGLMLPPQSTADSDVPTNLCIQPMVDNEPSRDSCKDLGMRQTSTGQQFL
7) TLKRNTLPIISEKSPNKENLSPSLSNNNRRINNIYDDG
2293
250
2490
1347
1934
2337
702
2332
283
2614
1932
2244
2391
739










Molecular Recognition Features






MoRF SequenceStartStop




1) GKMKQLEMIS
2) RAFKLL
3) TLQAAQKMLPTKMMLAAAGMK
1872
2213
2099
1881
2218
2119