<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06844

Description Mediator of RNA polymerase II transcription subunit 16 (Fragment)
SequenceCSLSSRNIVAFTTMTELDDSSGKTRGCHVYVADLNMPWHAHKVLSNKHNITALEWDLPGDKLVMADTAGNVQLWIFKDHILNDWILIGSAYFPGEHILGAAWFHNGKKTGLVTEKKDSIHYSEKFNHLLFAPSVRQFGGRAAEGVLVVSTTGMVGAIMITKDLQNPICYSTESLGNTRHRITAVDLCYGKNGHFLVAVSSGSICLPIRCFRVLVRKNDDKCTITSQALPSFFLQDGAPKDNSCTVVTHLKFVVREDADSLVIAANSESGGFVEVWELREKSQPVHKLFQPKTLEPFKTVVWQYQSQYRCQSPVTAIATTKLSIVTTLPPPSYVIIALADSSVHCLNRLDCLKEVAFSSLNTSWRPDEPSNKYFKNSVSIAHMDLSWLGCVLLACDTQGNMYLYKLLPDGTTGTSMSLSYACTLLEYCLVTGLDWLDILLCLRSSMIEALCERLDVSFNRQLQSTQQYHYILFLSIKTSLYRMLVTGQNKAADLSSLLMIHSVATAFKSLLRPSDLISHDKGPAESLAVVITDVITDVDKVLLHLDPKEFTVEPSTLQSLQQLIQWVADLALNLLARLPEQRMQVKTGGYELLKDHKALNTVRELLVIIRIWGLLRPSCLPVFLRSADNLDVLALLFCLLSKLVQPNGDTQQQVDDGLIGKSEIHRVHEDIMTTKLAIKHKDSLVLKENRLHEKNYTIQQSRLKRCEHLSLPWSTLSVFVVYWLVFCPLIWAICYKFAYWPSYWSFLFWAVAFLIWIVIMCGLIIFWRRFQVEQSFKINAISKYGSDKERRPLSVHQILSEDSKFLGTKKWNDFHESESKIVRENLRRDLPPLVIHKQISGENIEDTDGVVCVEENEKTHLSIAGDYAQKSPLQDYLKLVTVSPSEDEVKSPKTPMSPRDLFFIDLIHEAERAEKSLKTGTHFFPSETTENDSAETVKSITNGTDMENVEHRKDVKDTKNENVKDKEDNKLKSKRESNECCLLPNQIMIPQLHQGNSITAIVSPILFYQNLPLQLEYGVEPEQLVFTPEMNLVEGCMHSGQIVDTIRHLYLGRQPLLVKQCTRCGGKAQVQNMTRTAAIRAWDQRWTRACRCGGIWRIHKASQ
Length1102
PositionTail
OrganismTrachymyrmex cornetzi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.08
Grand average of hydropathy-0.130
Instability index45.87
Isoelectric point7.23
Molecular weight124767.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364149

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06844
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.22|      22|      26|     718|     742|       1
---------------------------------------------------------------------------
  718-  742 (39.07/32.91)	FvVYWLV.FcpLIWAI..CYKFAYWPSY
  745-  769 (37.15/19.71)	F.LFWAVaF..LIWIVimCGLIIFWRRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.05|      20|      22|     901|     920|       2
---------------------------------------------------------------------------
  901-  920 (34.90/30.75)	FFIDLIHEAERAE..KSLKTGT
  922-  943 (31.15/26.47)	FFPSETTENDSAEtvKSITNGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.97|      24|      26|    1039|    1064|       3
---------------------------------------------------------------------------
 1040- 1064 (39.25/24.12)	QIVDTIRHLYL.GRQPLLVKQCtRCG
 1068- 1092 (40.72/20.77)	QVQNMTRTAAIrAWDQRWTRAC.RCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.68|      16|     194|     432|     447|       4
---------------------------------------------------------------------------
  432-  447 (29.86/17.52)	LDWLDILLCLRSSMIE
  629-  644 (26.83/15.02)	LDVLALLFCLLSKLVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.82|      10|      22|     354|     363|       5
---------------------------------------------------------------------------
  354-  363 (17.96/ 8.67)	VAFSSLNTSW
  377-  386 (18.86/ 9.42)	VSIAHMDLSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.46|      15|     194|      60|      74|       7
---------------------------------------------------------------------------
   60-   74 (28.06/21.46)	DKLVMA...DTAGNVQLW
  258-  275 (22.39/15.45)	DSLVIAansESGGFVEVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.13|      21|      23|     665|     685|       8
---------------------------------------------------------------------------
  665-  685 (34.44/24.80)	RVHEDIMTTKLA.IKHKDSLVL
  689-  710 (31.69/22.20)	RLHEKNYTIQQSrLKRCEHLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.10|      10|      30|     389|     398|       9
---------------------------------------------------------------------------
  389-  398 (19.98/10.79)	CVLLA.CDTQG
  421-  431 (15.12/ 6.46)	CTLLEyCLVTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.87|      30|      30|     482|     511|      10
---------------------------------------------------------------------------
  482-  511 (47.04/29.91)	MLVTGQNKAADLSSLLMIHSVATAF.KSLLR
  513-  543 (42.83/26.62)	SDLISHDKGPAESLAVVITDVITDVdKVLLH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06844 with Med16 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SLKTGTHFFPSETTENDSAETVKSITNGTDMENVEHRKDVKDTKNENVKDKEDNKL
915
970










Molecular Recognition Features






MoRF SequenceStartStop




1) IWRIHK
1094
1099